{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:19:46Z","timestamp":1790108386852,"version":"4.0.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["6905134"],"award-info":[{"award-number":["6905134"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["8601286"],"award-info":[{"award-number":["8601286"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Peritoneal dialysis (PD) is a home-based renal replacement therapy. Since hospital staff are not often familiar with PD and its complications, PD patients may have an excess risk of developing PD-related peritonitis during hospital admission for unrelated reasons, and the outcome may be affected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed 371 episodes of hospital-acquired PD peritonitis in our center from 2000 to 2019. Their clinical characteristics and outcomes were compared with 825 episodes that required hospital admission and 1964 episodes that were treated as outpatient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Hospitalized PD patients had a significantly higher risk of developing peritonitis than outpatients [incident rate ratio 4.41 (95% confidence interval 3.95\u20134.91]. Hospital-acquired peritonitis episodes were more commonly culture negative. Bacterial isolates from the hospital-acquired episodes were more likely resistant to ceftazidime (P &amp;lt;\u00a0.0001) than the other groups. The primary response rate, complete cure rate and overall mortality of the hospital-acquired episodes were 66.6%, 62.0%, and 23.2%, respectively, all worse than episodes that developed outside the hospital (P &amp;lt;\u00a0.0001 for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PD patients admitted to the hospital had a 4-fold increase in the risk of developing peritonitis. Hospital-acquired peritonitis episodes were more likely culture negative and resistant to antibiotics. They also had a lower primary response rate, a lower complete cure rate and higher mortality than episodes that developed outside the hospital.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfac164","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:47:08Z","timestamp":1656967628000},"page":"2107-2115","source":"Crossref","is-referenced-by-count":8,"title":["Excessive risk and poor outcome of hospital-acquired peritoneal dialysis-related peritonitis"],"prefix":"10.1093","volume":"15","author":[{"given":"Cheuk-Chun","family":"Szeto","sequence":"first","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince of Wales Hospital , Hong Kong , China"},{"name":"Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong , Shatin, Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-9611","authenticated-orcid":false,"given":"Jack Kit-Chung","family":"Ng","sequence":"additional","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince of Wales Hospital , Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-7628","authenticated-orcid":false,"given":"Winston Wing-Shing","family":"Fung","sequence":"additional","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince of Wales Hospital , Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon Chun-Kau","family":"Chan","sequence":"additional","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince 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Wales Hospital , Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Kam-Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince of Wales Hospital , Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Bon","family":"Leung","sequence":"additional","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince of Wales Hospital , Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Ming","family":"Chow","sequence":"additional","affiliation":[{"name":"Carol and Richard Yu Peritoneal Dialysis Research Centre, Departments of Medicine and Therapeutics, Prince of Wales Hospital , Hong Kong , 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