{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:32:36Z","timestamp":1790659956260,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Kidney Donor Profile Index (KDPI) is routinely reported by the donation agencies in Australia. We determined the association between KDPI and short-term allograft loss and assessed if this association was modified by the estimated post-transplant survival (EPTS) score and total ischaemic time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the Australia and New Zealand Dialysis and Transplant Registry, the association between KDPI (in quartiles) and 3-year overall allograft loss was examined using adjusted Cox regression analysis. The interactive effects between KDPI, EPTS score and total ischaemic time on allograft loss were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4006 deceased donor kidney transplant recipients transplanted between 2010 and 2015, 451 (11%) recipients experienced allograft loss within 3\u00a0years post-transplant. Compared with recipients of kidneys with a KDPI of 0\u201325%, recipients who received donor kidneys with a KDPI &amp;gt;75% experienced a 2-fold increased risk of 3-year allograft loss {adjusted hazard ratio [HR] 2.04 [95% confidence interval (CI) 1.53\u20132.71]}. The adjusted HRs for kidneys with a KDPI of 26\u201350% and 51\u201375% were 1.27 (95% CI 0.94\u20131.71) and 1.31 (95% CI 0.96\u20131.77), respectively. There were significant interactions between KDPI and EPTS scores (P-value for interaction &amp;lt;.01) and total ischaemic time (P-value for interaction &amp;lt;.01) such that the associations between higher KDPI quartiles and 3-year allograft loss were strongest in recipients with the lowest EPTS scores and longest total ischaemic time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recipients with higher post-transplant expected survival and transplants with longer total ischaemia who received donor allografts with higher KDPI scores experienced a greater risk of short-term allograft loss compared with those recipients with reduced post-transplant expected survival and with shorter total ischemia.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ckj\/sfac243","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T23:58:15Z","timestamp":1667260695000},"page":"473-483","source":"Crossref","is-referenced-by-count":10,"title":["Kidney Donor Profile Index and allograft outcomes: interactive effects of estimated post-transplant survival score and ischaemic time"],"prefix":"10.1093","volume":"16","author":[{"given":"Janelle","family":"Prunster","sequence":"first","affiliation":[{"name":"Department of Renal Medicine, Sir Charles Gairdner Hospital , Nedlands, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health, Sydney University , Sydney, NSW , Australia"},{"name":"Centre for Kidney Research, Children's Hospital at Westmead , Sydney, NSW , Australia"},{"name":"Department of Renal Medicine and National Pancreas Transplant Unit, Westmead Hospital , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Larkins","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Perth Children's Hospital , Perth, WA , Australia"},{"name":"School of Paediatrics and Child Health, University of Western Australia , Perth, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Wyburn","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Royal Prince Alfred Hospital , Sydney, NSW , Australia"},{"name":"Charles Perkins Centre Kidney Node, University of Sydney , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Princess Alexandra Hospital , Brisbane, QLD , Australia"},{"name":"Faculty of Medicine, University of Queensland , Brisbane, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Mulley","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Medical Centre , Melbourne, VIC , Australia"},{"name":"Department of Medicine, Monash University , Melbourne, VIC , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Ooi","sequence":"additional","affiliation":[{"name":"Medical School, University of Western Australia , Perth, WA , Australia"},{"name":"School of Biomedical Sciences, University of Western Australia , Perth, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Pilmore","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Auckland City Hospital , Auckland , New Zealand"},{"name":"Department of Medicine, University of Auckland , Auckland , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E","family":"Davies","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide , Adelaide, SA , Australia"},{"name":"Australia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute , Adelaide, SA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai H","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Sir Charles Gairdner Hospital , Nedlands, WA , Australia"},{"name":"Internal Medicine, University of Western Australia Medical School , Perth, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"2023022812302291600_","volume-title":"2019 Annual Report, Section 4. 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