{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:25:49Z","timestamp":1791239149492,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Wai Hung Charitable Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Various glomerular pathologies have been reported in patients who have undergone haematopoietic stem cell transplantation (HSCT), but the data on clinico-pathological correlations and clinical outcome remain limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed the clinical and histopathological data of patients who had biopsy-proven de novo glomerular diseases after HSCT since 1999.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2204 patients underwent HSCT during the period 1999\u20132021, and 31 patients (1.4%) developed de novo glomerular diseases after a mean duration of 2.8\u00a0\u00b1\u00a02.7 years after HSCT. Fifteen of these patients (48.4%) had graft-versus-host-disease prior to or concomitant with renal abnormalities. Proteinuria and eGFR at the time of kidney biopsy were 4.1\u00a0\u00b1\u00a05.3\u00a0g\/day and 50.8\u00a0\u00b1\u00a025.4\u00a0mL\/min\/1.73 m2, respectively. Kidney histopathologic diagnoses included thrombotic microangiopathy (TMA) (38.7%), membranous nephropathy (MN) (25.8%), mesangial proliferative glomerulonephritis (12.9%), minimal change disease (9.7%), focal segmental glomerulosclerosis (9.7%) and membranoproliferative glomerulonephritis (3.2%). Immunosuppressive treatment was given to patients who presented with nephrotic-range proteinuria and\/or acute kidney injury, while renin\u2013angiotensin\u2013aldosterone blockade was given to all patients with proteinuria \u22651\u00a0g\/day, with complete and partial response rates of 54.8% and 19.4%, respectively. One patient with TMA progressed to end-stage kidney disease after 24 weeks, and two patients, one with TMA and one with MN, (6.4%) progressed to chronic kidney disease (CKD) Stage \u22653. Kidney and patient survival rates were 96.6% and 83.5%, respectively, at 5 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>De novo glomerular diseases with diverse histopathologic manifestations affect 1.4% of patients after HSCT, and approximately 10% develop progressive CKD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfac264","type":"journal-article","created":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:37:05Z","timestamp":1670719025000},"page":"976-984","source":"Crossref","is-referenced-by-count":14,"title":["Clinico-pathological correlations and outcomes of <i>de novo<\/i> glomerular diseases in patients after haematopoietic stem cell transplantation"],"prefix":"10.1093","volume":"16","author":[{"given":"Desmond Y H","family":"Yap","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-2660","authenticated-orcid":false,"given":"Davina","family":"Lie","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S Y","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Haematology, Medical Oncology and Haematopoietic Stem Cell Transplantation, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joycelyn","family":"Sim","sequence":"additional","affiliation":[{"name":"Division of Haematology, Medical Oncology and Haematopoietic Stem Cell Transplantation, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert K W","family":"Lie","sequence":"additional","affiliation":[{"name":"Division of Haematology, Medical Oncology and Haematopoietic Stem Cell Transplantation, Queen Mary Hospital, The University of Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak 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