{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:09Z","timestamp":1792785849745,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Grant Ricerca Corrente"},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cardio-renal syndrome is a clinical condition that has recently been well defined. In acute kidney disease, this interaction might trigger chronic processes determining the onset of cardiovascular events and the progression of chronic kidney disease. Moreover, the high mortality rate of acute kidney injury (AKI) is also linked to the fact that this condition is often complicated by dysfunctions of other organs such as lungs or heart, or is associated with septic episodes.<\/jats:p>\n                  <jats:p>In this context the role and the potential link between bone, heart and kidney is becoming an important topic of research. The aim of this review is to describe the cardiac alterations in the presence of AKI (cardiorenal syndrome type 3) and explore how bone can interact with heart and kidney in determining and influencing the trend of AKI in the short and long term. The main anomalies of mineral metabolism in patients with AKI will be reported, with specific reference to the alterations of fibroblast growth factor 23 and Klotho as a link between the bone\u2013kidney\u2013heart axis.<\/jats:p>","DOI":"10.1093\/ckj\/sfad093","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T07:21:14Z","timestamp":1682493674000},"page":"1555-1562","source":"Crossref","is-referenced-by-count":10,"title":["Is there a role in acute kidney injury for FGF23 and Klotho?"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-022X","authenticated-orcid":false,"given":"Deborah","family":"Mattinzoli","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Molinari","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"},{"name":"Post-Graduate School of Specialization in Nephrology, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-3678","authenticated-orcid":false,"given":"Gregorio","family":"Romero-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Germans Trias i Pujol University Hospital, Research Group on Renal Diseases (REMAR), Germans Trias i Pujol Research Institute, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bover","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Germans Trias i Pujol University Hospital, Research Group on Renal Diseases (REMAR), Germans Trias i Pujol Research Institute, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cicero","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"},{"name":"Post-Graduate School of Specialization in Nephrology, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pesce","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J) University of Bari \u201cAldo Moro"},{"name":"\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Abinti","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"},{"name":"Post-Graduate School of Specialization in Nephrology, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"},{"name":"Post-Graduate School of Specialization in Nephrology, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Castellano","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-5219","authenticated-orcid":false,"given":"Carlo","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca\u2019 Granda Ospedale Policlinico , Milan , Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"2023092902522646700_bib1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1053\/j.ackd.2018.08.004","article-title":"Cardiorenal syndrome: an overview","volume":"25","author":"Ronco","year":"2018","journal-title":"Adv Chronic Kidney Dis"},{"key":"2023092902522646700_bib2","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. 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