{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:31:49Z","timestamp":1769157109345,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Proper assessment of donor organ quality is crucial for optimal kidney allocation and best long-term outcomes. The aim of this study was to analyze the association between the Kidney Donor Risk Index (KDRI) and histological parameters in early post-transplant graft biopsy in a Polish cohort of kidney transplant recipients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 418 consecutive kidney transplant recipients, a histological evaluation of very early [at median 11 (9\u201313) post-transplant day] protocol core needle biopsy was performed and analyzed according to the Banff classification. Subjects were divided into quartiles of the KDRI value. Kidney graft function, patient and graft survival were also analyzed over a median follow-up period of 44 (26\u201356) months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was a significant trend toward greater intensity of chronic histology changes along the KDRI quartiles (\u03c72\u00a0=\u00a020.8; P\u00a0&amp;lt;\u00a0.001), including interstitial fibrosis, tubular atrophy, mesangial matrix increase and arteriolar hyalinosis. Stepwise multivariate regression analysis revealed that only higher KDRI value independently increased the severity of chronic graft injury (rpartial\u00a0=\u00a00.340, P\u00a0&amp;lt;\u00a0.001). KDRI values were valuable in the determination of both early and long-term graft function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The KDRI values correlate with chronic histological changes found in early post-implantation kidney biopsies and can also be helpful in the prediction of graft outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfad124","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:10:55Z","timestamp":1686881455000},"page":"2226-2234","source":"Crossref","is-referenced-by-count":1,"title":["Association between Kidney Donor Risk Index, kidney graft function and histological changes in early post-transplant graft biopsy"],"prefix":"10.1093","volume":"16","author":[{"given":"Natalia","family":"S\u0142abiak-B\u0142a\u017c","sequence":"first","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Kujawa-Szewieczek","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-1872","authenticated-orcid":false,"given":"Aureliusz","family":"Kolonko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Zi\u00f3\u0142kowska","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Karkoszka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Wi\u0119cek","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8371-0195","authenticated-orcid":false,"given":"Grzegorz","family":"Piecha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia , Katowice , Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"2023103104565568100_bib1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant","volume":"341","author":"Wolfe","year":"1999","journal-title":"N Engl J Med"},{"key":"2023103104565568100_bib2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/ckj\/sfac232","article-title":"Collaboration between local nephrologists and the transplant centre ensures good outcomes in post-transplant care","volume":"16","author":"Kaufmann","year":"2023","journal-title":"Clin Kidney J"},{"key":"2023103104565568100_bib3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/00007890-200211150-00014","article-title":"Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors","volume":"74","author":"Port","year":"2002","journal-title":"Transplantation"},{"key":"2023103104565568100_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1681\/ASN.V123589","article-title":"Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates","volume":"12","author":"Ojo","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"2023103104565568100_bib5","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.2215\/CJN.02270409","article-title":"The alphabet soup of kidney transplantation: SCD, DCD, ECD\u2014fundamentals for the practicing nephrologist","volume":"4","author":"Rao","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023103104565568100_bib6","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1681\/ASN.V10122591","article-title":"Early experience with dual kidney transplantation in adults using expanded donor criteria. 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