{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:24Z","timestamp":1787008644332,"version":"build-2736575974"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Radiation nephropathy is a rare complication following total body irradiation (TBI) and peptide receptor radionuclide therapy (PRRT). Yttrium 90-DOTATOC (Y90) is a somatostatin analogue labelled with Y90 used for somatostatin-positive neuroendocrine tumours. Y90 is renally excreted and has a cumulative effect in the renal parenchyma Despite fractionation and co-administration of renoprotective intravenous amino acids, targeted radionuclide therapy can still be nephrotoxic. Rising adoption of PRRT has led to the re-emergence of radiation nephropathy. We report on three recent cases of insidious onset of progressive kidney dysfunction and biopsy-proven thrombotic microangiopathy following PRRT and TBI.<\/jats:p>","DOI":"10.1093\/ckj\/sfad133","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T23:18:52Z","timestamp":1685575132000},"page":"1534-1537","source":"Crossref","is-referenced-by-count":6,"title":["Radiation nephropathy is associated with a glomerular thrombotic microangiopathy and progression to end-stage kidney disease"],"prefix":"10.1093","volume":"16","author":[{"given":"Isabela","family":"Bertoni","sequence":"first","affiliation":[{"name":"Oxford Kidney Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S D","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Connor","sequence":"additional","affiliation":[{"name":"Oxford Kidney Unit"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2023083104275388700_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cpet.2013.10.001","article-title":"Yttrium-based therapy for neuroendocrine tumours","volume":"9","author":"Bodei","year":"2014","journal-title":"PET Clin"},{"key":"2023083104275388700_bib2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/MNM.0000000000001198","article-title":"Nephrotoxicity\/renal failure after therapy with 90Yttrium- and 177Lutetium-radiolabeled somatostatin analogs in different types of neuroendocrine tumors: a systematic review","volume":"41","author":"Stolniceanu","year":"2020","journal-title":"Nucl Med Commun"},{"key":"2023083104275388700_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0272-6386(01)80135-9","article-title":"A new cause of renal thrombotic microangiopathy: yttrium 90-DOTATOC internal radiotherapy","volume":"37","author":"Moll","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"2023083104275388700_bib4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jacbts.2018.01.014","article-title":"Radiation-induced endothelial vascular injury. A review of possible mechanisms","volume":"3","author":"Venkatesulu","year":"2018","journal-title":"JACC Basic Transl Sci"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfad133\/51004150\/sfad133.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/16\/9\/1534\/51294895\/sfad133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/16\/9\/1534\/51294895\/sfad133.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:08:12Z","timestamp":1702544892000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/16\/9\/1534\/7188304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":4,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfad133","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,6,1]]}}}