{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:51:02Z","timestamp":1790887862197,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hospital Puerta de Hierro Majadahonda Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cardiorenal programs have emerged to improve the management of cardiorenal disease (CRD). Evidence about the benefits of these programs is still scarce. This work aims to evaluate the performance of a novel cardiorenal program and describe the clinical profile and outcomes of patients with CRD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective observational study of patients with CRD attended in a cardiorenal unit (CRU) from February 2021 to February 2022. Demographics and laboratory tests were collected and events (all-cause death and cardiovascular hospitalizations) were evaluated. Optimization of comorbidities and protective therapies was also assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-two patients were included, with a mean age of 76.8\u00a0years [standard deviation (SD) 8.5] and 72% were men. A total of 58.5% (n\u00a0=\u00a047) had left ventricular ejection fraction &amp;lt;50%. The mean follow-up was 11\u00a0months (SD 4.0). Almost 54% of the patients (n\u00a0=\u00a044) required hospitalization, 30.5% for heart failure (HF) decompensation. Total hospitalizations significantly decreased after CRU inclusion: 0.70 versus 0.45 admissions\/year (P\u00a0&amp;lt;\u00a0.02). Global mortality was 17.1% (n\u00a0=\u00a014). The percentage of patients with HF with reduced ejection fraction on quadruple therapy increased by 20%, and up to 60% of the patients were on three drugs. A total of 39% of the patients with HF and preserved ejection fraction started treatment with sodium\u2013glucose co-transporter inhibitors. Hyperkalaemia required the use of potassium binders in 12.2% of the patients and treatment of secondary hyperparathyroidism was started in 42.7% and renal anaemia in 23.2%. Renal replacement therapy was initiated in 10% of the patients (n\u00a0=\u00a08).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CRD confers a considerable risk of adverse outcomes. Cardiorenal programs may improve cardiorenal syndrome management by optimizing therapies, treating comorbidities and reducing hospitalizations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfad169","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T01:05:11Z","timestamp":1689296711000},"page":"2100-2107","source":"Crossref","is-referenced-by-count":18,"title":["Multidisciplinary approach to patients with heart failure and kidney disease: preliminary experience of an integrated cardiorenal unit"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-2546","authenticated-orcid":false,"given":"Mar\u00eda","family":"Marques","sequence":"first","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"},{"name":"Medicine Department, Facultad de Medicina, Universidad Aut\u00f3noma Madrid , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-061X","authenticated-orcid":false,"given":"Marta","family":"Cobo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Cardiovasculares (CIBERCV) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-5759","authenticated-orcid":false,"given":"Paula","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Garc\u00eda-Magall\u00f3n","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-6377","authenticated-orcid":false,"given":"Mar\u00eda Luisa Serrano","family":"Salazar","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"},{"name":"RETIC ISCIII REDinREN 16\/009\/009"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-9214","authenticated-orcid":false,"given":"Jorge V","family":"L\u00f3pez-Ibor","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo","family":"Janeiro","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"},{"name":"RETIC ISCIII REDinREN 16\/009\/009"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefanya","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"},{"name":"RETIC ISCIII REDinREN 16\/009\/009"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S\u00e1nchez","family":"Briales","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Montero","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria L\u00f3pez","family":"Illazquez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Soria","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Mart\u00ednez","family":"Citores","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mart\u00ednez","family":"Peral","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Segovia","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro Majadahonda , IDIPHISA, Madrid , Spain"},{"name":"Medicine 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