{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:17:04Z","timestamp":1790252224090,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Capital Region of Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma (p-)activin A is elevated in chronic kidney disease\u2013mineral and bone disorder (CKD-MBD). Activin A inhibition ameliorates CKD-MBD complications (vascular calcification and bone disease) in rodent CKD models. We examined whether p-activin A was associated with major adverse cardiovascular events (MACE), all-cause mortality and CKD-MBD complications in CKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 916 participants (741 patients and 175 controls) from the prospective Copenhagen CKD cohort. Comparisons of p-activin A with estimated glomerular filtration rate (eGFR), coronary and thoracic aorta Agatston scores, and bone mineral density (BMD) were evaluated by univariable linear regression using Spearman's rank correlation, analysis of covariance and ordinal logistic regression with adjustments. Association of p-activin A with rates of MACE and all-cause mortality was evaluated by the Aalen\u2013Johansen or Kaplan\u2013Meier estimator, with subsequent multiple Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>P-activin A was increased by CKD stage 3 (124\u2013225\u00a0pg\/mL, P\u00a0&amp;lt;\u00a0.001) and correlated inversely with eGFR (r\u00a0=\u00a0\u22120.53, P\u00a0&amp;lt;\u00a00.01). P-activin A was associated with all-cause mortality [97 events, hazard ratio 1.55 (95% confidence interval 1.04; 2.32), P\u00a0&amp;lt;\u00a00.05] after adjusting for age, sex, diabetes mellitus (DM) and eGFR. Median follow-up was 4.36 (interquartile range 3.64\u20134.75) years. The association with MACE was not significant after eGFR adjustment. Agatston scores and BMD were not associated with p-activin A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>P-activin A increased with declining kidney function and was associated with all-cause mortality independently of age, sex, DM and eGFR. No association with MACE, vascular calcification or BMD was demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfad238","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T08:41:18Z","timestamp":1695112878000},"page":"2712-2720","source":"Crossref","is-referenced-by-count":12,"title":["Plasma activin A rises with declining kidney function and is independently associated with mortality in patients with chronic kidney disease"],"prefix":"10.1093","volume":"16","author":[{"given":"Anders","family":"Nordholm","sequence":"first","affiliation":[{"name":"Department of Nephrology, Rigshospitalet , Copenhagen , Denmark"},{"name":"Department of Nephrology, Herlev & Gentofte Hospital , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-5812","authenticated-orcid":false,"given":"Ida M 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino E","family":"Landler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev & Gentofte Hospital , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Biering-S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Cardiology, Herlev & Gentofte Hospital , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rigshospitalet , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Feldt-Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rigshospitalet , Copenhagen , Denmark"},{"name":"Department of Clinical 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