{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:26:07Z","timestamp":1792513567614,"version":"4.5.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic kidney disease mineral bone disorder (CKD-MBD) is a condition characterized by alterations of calcium, phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF-23) metabolism that in turn promote bone disorders, vascular calcifications, and increase cardiovascular (CV) risk. Nephrologists\u2019 awareness of diagnostic, prognostic, and therapeutic tools to manage CKD-MBD plays a primary role in adequately preventing and managing this condition in clinical practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A national survey (composed of 15 closed questions) was launched to inquire about the use of bone biomarkers in the management of CKD-MBD patients by nephrologists and to gain knowledge about the implementation of guideline recommendations in clinical practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred and six Italian nephrologists participated in the survey for an overall response rate of about 10%. Nephrologists indicated that the laboratories of their hospitals were able to satisfy request of ionized calcium levels, 105 (99.1%) of both PTH and alkaline phosphatase (ALP), 100 (94.3%) of 25(OH)D, and 61 (57.5%) of 1.25(OH)2D; while most laboratories did not support the requests of biomarkers such as FGF-23 (intact: 88.7% and c-terminal: 93.4%), Klotho (95.3%; soluble form: 97.2%), tartrate-resistant acid phosphatase 5b (TRAP-5b) (92.5%), C-terminal telopeptide (CTX) (71.7%), and pro-collagen type 1 N-terminal pro-peptide (P1NP) (88.7%). As interesting data regarding Italian nephrologists\u2019 behavior to start treatment of secondary hyperparathyroidism (sHPT), the majority of clinicians used KDOQI guidelines (n\u00a0=\u00a055, 51.9%). In contrast, only 40 nephrologists (37.7%) relied on KDIGO guidelines, which recommended referring to values of PTH between two and nine times the upper limit of the normal range.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Results point out a marked heterogeneity in the management of CKD-MBD by clinicians as well as a suboptimal implementation of guidelines in Italian clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfad290","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T05:41:35Z","timestamp":1701322895000},"source":"Crossref","is-referenced-by-count":25,"title":["Real-world usage of Chronic Kidney Disease \u2013 Mineral Bone Disorder (CKD\u2013MBD) biomarkers in nephrology practices"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-4851","authenticated-orcid":false,"given":"Maria","family":"Fusaro","sequence":"first","affiliation":[{"name":"National Research Council (CNR), Institute of Clinical Physiology (IFC) , Pisa , Italy"},{"name":"Department of Medicine, University of Padova , Padova , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Barbuto","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-2160","authenticated-orcid":false,"given":"Maurizio","family":"Gallieni","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u2018Luigi Sacco\u2019 , Universita\u0300 di Milano, Milano , Italy"},{"name":"Post-Graduate School of Specialization in Nephrology, University of Milano , Milano , Italy"},{"name":"Division of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale (ASST) Fatebenefratelli-Sacco, Fatebenefratelli Hospital , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Althea","family":"Cossettini","sequence":"additional","affiliation":[{"name":"Post-Graduate School of Specialization in Nephrology, University of Milano , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Vanessa","family":"Re Sart\u00f2","sequence":"additional","affiliation":[{"name":"Post-Graduate School of Specialization in Nephrology, University of Milano , Milano , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-4232","authenticated-orcid":false,"given":"Laura","family":"Cosmai","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale (ASST) Fatebenefratelli-Sacco, Fatebenefratelli Hospital , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"La Manna","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna , Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-1896","authenticated-orcid":false,"given":"Thomas","family":"Nickolas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Columbia University , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-4417","authenticated-orcid":false,"given":"Serge","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Service des Maladies Osseuses, D\u00e9partement de M\u00e9decine, HUG , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bover","sequence":"additional","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Hospital Universitario Germans Trias i Pujol , Badalona (Barcelona), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Haarhaus","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Marino","sequence":"additional","affiliation":[{"name":"National Research Council (CNR), Institute of Clinical Physiology (IFC) , Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Mereu","sequence":"additional","affiliation":[{"name":"Independent Researcher , Cagliari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Ravera","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis, and Transplantation, University of Genoa and Policlinico San Martino , 16132 Genoa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-1711","authenticated-orcid":false,"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Unit, Department of Medicine, University of Padua , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zaninotto","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Unit, Department of Medicine, University of Padua , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-6252","authenticated-orcid":false,"given":"Mario","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Renal Division, University of Milan , ASST Santi Paolo e Carlo, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Nephrology and Dialysis Complex Operative Unit, Livorno , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1512-559X","authenticated-orcid":false,"given":"Piergiorgio","family":"Messa","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Gregorini","sequence":"additional","affiliation":[{"name":"SC Nefrologia e Dialisi AUSL-IRCCS Reggio Emilia, Reggio Emilia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Gasperoni","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, Infermi Hospital , AUSL Romagna, Rimini , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Agosto","sequence":"additional","affiliation":[{"name":"Pediatric Pain and Palliative Care Service, Department of Women's and Children's Health, Padua University Hospital , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aghi","sequence":"additional","affiliation":[{"name":"Independent Researcher , Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tripepi","sequence":"additional","affiliation":[{"name":"National Research Council (CNR), Institute of Clinical Physiology (IFC) , Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"2024011209305447100_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ndt\/gfy126","article-title":"Klotho and endocrine fibroblast growth factors: markers of chronic kidney disease progression and cardiovascular complications?","volume":"34","author":"Kuro-O","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"2024011209305447100_bib2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2215\/CJN.10390917","article-title":"Parathyroidectomy in the management of secondary hyperparathyroidism","volume":"13","author":"Lau","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"2024011209305447100_bib3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00223-020-00777-1","article-title":"Chronic kidney disease\u2014mineral and bone disorders: pathogenesis and management","volume":"108","author":"Cannata-And\u00eda","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"2024011209305447100_bib4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.12688\/f1000research.22636.1","article-title":"Recent advances in understanding and managing secondary hyperparathyroidism in chronic kidney disease","volume":"9","author":"Rodr\u00edguez-Ortiz","year":"2020","journal-title":"F1000Res"},{"key":"2024011209305447100_bib5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrneph.2009.192","article-title":"Bone disease after renal transplantation","volume":"6","author":"Malluche","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"2024011209305447100_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.ajkd.2021.06.031","article-title":"Diagnosis and management of osteoporosis in advanced kidney disease: a review","volume":"79","author":"Ginsberg","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"2024011209305447100_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMp038101","article-title":"Periosteal bone formation\u2014a neglected determinant of bone strength","volume":"349","author":"Seeman","year":"2003","journal-title":"N Engl J Med"},{"key":"2024011209305447100_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bone.2008.09.017","article-title":"Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited","volume":"44","author":"Teti","year":"2009","journal-title":"Bone"},{"key":"2024011209305447100_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jsbmb.2014.01.002","article-title":"Vitamin D receptor overexpression in osteoblasts and osteocytes prevents bone loss during vitamin D-deficiency","volume":"44","author":"Lam","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2024011209305447100_bib10","first-page":"68","article-title":"Estrogen receptor \u03b1 in osteocytes regulates trabecular bone formation in female mice","volume-title":"Bone","author":"Kondoh","year":"2014"},{"key":"2024011209305447100_bib11","first-page":"250","article-title":"Effects of PTH on osteocyte function","volume-title":"Bone","author":"Bellido","year":"2013"},{"key":"2024011209305447100_bib12","doi-asserted-by":"crossref","first-page":"e10234","DOI":"10.1002\/jbm4.10234","article-title":"The importance of biologically active vitamin D for mineralization by osteocytes after parathyroidectomy for renal hyperparathyroidism","volume":"3","author":"Yajima","year":"2019","journal-title":"JBMR Plus"},{"key":"2024011209305447100_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ndt\/gfaa192","article-title":"European Consensus Statement on the diagnosis and management of osteoporosis in chronic kidney disease stages G4\u2013G5D","volume":"36","author":"Evenepoel","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2024011209305447100_bib14","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/nu14091742","article-title":"Time for revival of bone biopsy with histomorphometric analysis in chronic kidney disease (CKD): moving from skepticism to pragmatism","volume":"14","author":"Fusaro","year":"2022","journal-title":"Nutrients"},{"key":"2024011209305447100_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1479-5876-11-201","article-title":"The clinical utility of bone marker measurements in osteoporosis","volume":"11","author":"Wheater","year":"2013","journal-title":"J Transl Med"},{"key":"2024011209305447100_bib16","first-page":"946","article-title":"Determination of parathyroid hormone: from radioimmunoassay to LCMS\/MS","volume-title":"Clin Chem Lab Med","author":"Cavalier","year":"2023"},{"key":"2024011209305447100_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2009.374","article-title":"Parathyroid hormone measurement in CKD","volume":"77","author":"Souberbielle","year":"2010","journal-title":"Kidney Int"},{"key":"2024011209305447100_bib18","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.3390\/nu14102124","article-title":"Alkaline phosphatase: an old friend as treatment target for cardiovascular and mineral bone disorders in chronic kidney disease","volume":"14","author":"Haarhaus","year":"2022","journal-title":"Nutrients"},{"key":"2024011209305447100_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00223-013-9722-x","article-title":"High prevalence of vertebral fractures assessed by quantitative morphometry in hemodialysis patients, strongly associated with vascular calcifications","volume":"93","author":"Fusaro","year":"2013","journal-title":"Calcif Tissue Int"},{"key":"2024011209305447100_bib20","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.3390\/nu13103567","article-title":"The vessels-bone axis: iliac artery calcifications, vertebral fractures and vitamin K from VIKI study","volume":"13","author":"Fusaro","year":"2021","journal-title":"Nutrients"},{"key":"2024011209305447100_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO Chronic Kidney Disease\u2013Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int"},{"key":"2024011209305447100_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9150(97)00106-8","article-title":"New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study","volume":"132","author":"Kauppila","year":"1997","journal-title":"Atherosclerosis"},{"key":"2024011209305447100_bib23","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.3390\/nu14204276","article-title":"A novel quantitative computer-assisted score can improve repeatability in the estimate of vascular calcifications at the abdominal aorta","volume":"14","author":"Fusaro","year":"2022","journal-title":"Nutrients"},{"key":"2024011209305447100_bib24","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/ndt\/gfl837","article-title":"Significance of time-course changes of serum bone markers after parathyroidectomy in patients with uraemic hyperparathyroidism","volume":"22","author":"Yajima","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"2024011209305447100_bib25","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1093\/ndt\/gfu055","article-title":"A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan","volume":"29","author":"Maruyama","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"2024011209305447100_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ndt\/gfr317","article-title":"Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients\u2014a single-center cohort study","volume":"27","author":"Iimori","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2024011209305447100_bib27","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1053\/ajkd.2002.35692","article-title":"Clinical usefulness of the serum N-terminal propeptide of type I collagen as a marker of bone formation in hemodialysis patients","volume":"40","author":"Ueda","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"2024011209305447100_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00198-004-1712-4","article-title":"Serum levels of C-terminal telopeptide of type I collagen: a useful new marker of cortical bone loss in hemodialysis patients","volume":"16","author":"Okuno","year":"2005","journal-title":"Osteoporos Int"},{"key":"2024011209305447100_bib29","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00223-008-9127-4","article-title":"Serum levels of TRAP5b, a new bone resorption marker unaffected by renal dysfunction, as a useful marker of cortical bone loss in hemodialysis patients","volume":"82","author":"Shidara","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"2024011209305447100_bib30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/j.ajkd.2015.06.023","article-title":"Diagnostic accuracy of bone turnover markers and bone histology in patients with CKD treated by dialysis","volume":"67","author":"Sprague","year":"2016","journal-title":"Am J Kidney Dis"},{"key":"2024011209305447100_bib31","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1681\/ASN.2017050584","article-title":"Diagnostic accuracy of biomarkers and imaging for bone turnover in renal osteodystrophy","volume":"29","author":"Salam","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"2024011209305447100_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1053\/j.ajkd.2021.07.027","article-title":"Diagnostic accuracy of noninvasive bone turnover markers in renal osteodystrophy","volume":"79","author":"J\u00f8rgensen","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"2024011209305447100_bib33","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1681\/ASN.V73506","article-title":"Plasma total versus bone alkaline phosphatase as markers of bone turnover in hemodialysis patients","volume":"7","author":"Ure\u00f1a","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"2024011209305447100_bib34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1053\/j.ajkd.2012.04.014","article-title":"Associations of plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with death and progression to maintenance dialysis in patients with advanced kidney disease","volume":"60","author":"Kendrick","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"2024011209305447100_bib35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1681\/ASN.2013050465","article-title":"Fibroblast growth factor-23 and cardiovascular events in CKD","volume":"25","author":"Scialla","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"2024011209305447100_bib36","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1161\/CIRCRESAHA.120.318556","article-title":"Randomized trial of etelcalcetide for cardiac hypertrophy in hemodialysis","volume":"128","author":"D\u00f6rr","year":"2021","journal-title":"Circ Res"},{"key":"2024011209305447100_bib37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s00223-020-00792-2","article-title":"Vitamin K in CKD bone disorders","volume":"108","author":"Fusaro","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"2024011209305447100_bib38","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1210\/endrev\/bnac031","article-title":"Bone turnover markers: basic biology to clinical applications","volume":"44","author":"Schini","year":"2023","journal-title":"Endocr Rev"},{"key":"2024011209305447100_bib39","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/382448a0","article-title":"Increased bone formation in osteocalcin-deficient mice","volume":"382","author":"Ducy","year":"1996","journal-title":"Nature"},{"key":"2024011209305447100_bib40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jbmr.4214","article-title":"Sevelamer use, vitamin K levels, vascular calcifications, and vertebral fractures in hemodialysis patients: results from the VIKI study","volume":"36","author":"Fusaro","year":"2021","journal-title":"J Bone Miner Res"},{"key":"2024011209305447100_bib41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s40620-017-0406-x","article-title":"Uremic toxicity and bone in CKD","volume":"30","author":"Yamamoto","year":"2017","journal-title":"J Nephrol"},{"key":"2024011209305447100_bib42","doi-asserted-by":"crossref","first-page":"3485785","DOI":"10.1155\/2017\/3485785","article-title":"Molecular abnormalities underlying bone fragility in chronic kidney disease","volume":"2017","author":"Iwasaki","year":"2017","journal-title":"Biomed Res Int"},{"key":"2024011209305447100_bib43","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/kisup.2013.93","article-title":"Uremic osteoporosis","volume":"3","author":"Kazama","year":"2013","journal-title":"Kidney Int Suppl (2011)"},{"key":"2024011209305447100_bib44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bone.2013.07.037","article-title":"Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease","volume":"57","author":"Iwasaki","year":"2013","journal-title":"Bone"},{"key":"2024011209305447100_bib45","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1053\/j.ajkd.2017.07.019","article-title":"KDOQI US commentary on the 2017 KDIGO Clinical Practice guideline update for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney disease\u2013Mineral and bone disorder (CKD-MBD)","volume":"70","author":"Isakova","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"2024011209305447100_bib46","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/ckj\/sfz112","article-title":"Combinations of mineral and bone disorder markers and risk of death and hospitalizations in the international Dialysis Outcomes and Practice Patterns Study","volume":"13","author":"Fuller","year":"2020","journal-title":"Clin Kidney J"},{"key":"2024011209305447100_bib47","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00223-020-00781-5","article-title":"The non-invasive diagnosis of bone disorders in CKD","volume":"108","author":"Bover","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"2024011209305447100_bib48","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MNH.0000000000000798","article-title":"Clinical utility of bone turnover markers in patients with chronic kidney disease","volume":"31","author":"Smout","year":"2022","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2024011209305447100_bib49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11914-017-0362-3","article-title":"Biomarkers predicting bone turnover in the setting of CKD","volume":"15","author":"Evenepoel","year":"2017","journal-title":"Curr Osteoporos Rep"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfad290\/53941766\/sfad290.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/17\/1\/sfad290\/55554020\/sfad290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/17\/1\/sfad290\/55554020\/sfad290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T09:31:43Z","timestamp":1705051903000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/doi\/10.1093\/ckj\/sfad290\/7455904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,29]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfad290","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,11,29]]},"article-number":"sfad290"}}