{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:12:05Z","timestamp":1776791525181,"version":"3.51.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["cstc2021jcyj-bshX0109"],"award-info":[{"award-number":["cstc2021jcyj-bshX0109"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chongqing Wanzhou District Health and Science Collaborative Medical Research Project","award":["wzstc-kw2020002"],"award-info":[{"award-number":["wzstc-kw2020002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970618"],"award-info":[{"award-number":["81970618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170720"],"award-info":[{"award-number":["82170720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200906"],"award-info":[{"award-number":["82200906"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Disruptions in gene expression associated with the glomerular basement membrane (GBM) could precipitate glomerular dysfunction. Nevertheless, a comprehensive understanding of the characterization of GBM components within pediatric glomerular diseases and their potential association with glomerular function necessitates further systematic investigation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a systematic analysis focusing on the pathological transformations and molecular attributes of key constituents within the GBM, specifically Collagen IV \u03b13\u03b14\u03b15, Laminin \u03b15\u03b22\u03b31, and Integrin \u03b13\u03b21, across prevalent pediatric glomerular diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed upregulation of linear expression levels of COL4A3\/4\/5 and Laminin 5\u03b1 proteins, along with a partial reduction in the linear structural expression of Podocin in idiopathic nephrotic syndrome (INS), encompassing minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), but showing a reduction in IgA nephropathy (IgAN), IgA vasculitis nephritis (IgAVN) and lupus nephritis (LN). Furthermore, our study revealed reductions in Laminin \u03b22\u03b31 and Integrin \u03b13\u03b21 in both primary and secondary childhood glomerular diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In INS, notably MCD and FSGS, there is a notable increase in the linear expression levels of COL4A3\/4\/5 and Laminin 5\u03b1 proteins. In contrast, in IgAN, IgAVN, and LN, there is a consistent reduction in the expression of these markers. Furthermore, the persistent reduction of Laminin \u03b22\u03b31 and Integrin \u03b13\u03b21 in both primary and secondary childhood glomerular diseases suggests a shared characteristic of structural alterations within the GBM across these conditions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae037","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T03:40:40Z","timestamp":1708141240000},"source":"Crossref","is-referenced-by-count":4,"title":["Characterization of glomerular basement membrane components within pediatric glomerular diseases"],"prefix":"10.1093","volume":"17","author":[{"given":"Dan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanbing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"},{"name":"Chongqing University Three Gorges Hospital, School of Medicine of Chongqing University , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Renal Immunology Specialist Section, The Affiliated Hospital of Guizhou Medical University, Guizhou Provincial Children's Medical Center , Guiyang, Guizhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Renal Immunology Specialist Section, The Affiliated Hospital of Guizhou Medical University, Guizhou Provincial Children's Medical Center , Guiyang, Guizhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Hospital of Guizhou Medical University , Guiyang, Guizhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. 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