{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:09:07Z","timestamp":1791929347701,"version":"4.3.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Niercentrum aan de Amstel, Amstelveen, The\n Netherlands"},{"name":"B. Braun Avitum AG, Melsungen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Intradialytic hypotension (IDH) and subsequent tissue damage may contribute to the poor outcome of chronic haemodialysis (HD) patients. While the IDH-incidence is lower in high-volume haemodiafiltration (HV-HDF) than in standard HD (S-HD), survival is better in HV-HDF. Tissue injury, as measured by extracellular vesicle (EV)-release, was compared between four modalities.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Forty chronic patients were cross-over randomized to S-HD, cool-HD (C-HD), low-volume HDF (LV-HDF), and HV-HDF. Blood pressure was recorded every 15 minutes. EVs from circulating blood-cell-elements (bio-incompatibility-related) and cardiovascular (CV) tissues (CV-related), were measured before and after dialysis. The influence of modalities and IDH on the rate of change of EVs was assessed. Both crude and haemoconcentration-adjusted analyses were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Leukocyte and erythrocyte-derived EVs increased in all modalities. Platelet-derived EVs increased more in LV-HDF and HV-HDF (68.4 respectively 56.1\u00a0\u00d7\u00a0106\/ml) than in S-HD (27.5\u00a0\u00d7\u00a0106\/ml), P values for interaction were &lt;.01 respectively .06. Endothelial-derived CD144+ (2.3\u00a0\u00d7\u00a0106\/ml in HV-HDF and 9.8\u00a0\u00d7\u00a0106\/ml in S-HD) and cardiomyocyte-derived Connexin-43+ (12.0 respectively 31.9\u00a0\u00d7\u00a0106\/ml) EVs increased less in HV-HDF than in S-HD (P for interaction .03 respectively .06). Correction for haemoconcentration attenuated all changes, although the increase in platelet-derived EVs remained significant in LV-HDF and HV-HDF, and CD144+ and Connexin-43+ EVs increased most in S-HD. EV release was similar in patients with varying IDH susceptibility and in sessions with and without IDH.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Most EVs increase during HD and HDF. Regarding platelet-derived EVs, HDF appears less biocompatible than HD. Considering CV-related EVs, tissue injury seems less pronounced in HV-HDF. The finding that EV release is IDH-independent needs confirmation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ckj\/sfae134","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T02:46:46Z","timestamp":1714445206000},"source":"Crossref","is-referenced-by-count":5,"title":["Intradialytic cardiovascular injury is lowest in high-volume\n haemodiafiltration: a randomized cross-over trial in four intermittent dialysis\n strategies"],"prefix":"10.1093","volume":"17","author":[{"given":"Peiyun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Amsterdam UMC, location Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Renal Medicine, Singapore General Hospital, Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-5268","authenticated-orcid":false,"given":"Paul A","family":"Rootjes","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Amsterdam UMC, location Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Internal Medicine, Gelre Hospitals , Apeldoorn ,","place":["the Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences (ACS), Diabetes & Metabolism , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-8341","authenticated-orcid":false,"given":"Camiel L M","family":"de Roij van Zuijdewijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Amsterdam UMC, location Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences (ACS), Diabetes & Metabolism , Amsterdam ,","place":["the Netherlands"]},{"name":"Department of Internal Medicine , Spaarne Gasthuis, Haarlem ,","place":["the\n Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi M","family":"Hau","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Center, University of Amsterdam , Amsterdam ,","place":["the\n Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menso J","family":"Nub\u00e9","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Amsterdam UMC, location Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences (ACS), Diabetes & Metabolism , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-3400","authenticated-orcid":false,"given":"Rienk","family":"Nieuwland","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Clinical Chemistry, Amsterdam University Medical Center, University of Amsterdam , Amsterdam ,","place":["the\n Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude","family":"Wijngaarden","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Amsterdam UMC, location Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences (ACS), Diabetes & Metabolism , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel P C","family":"Grooteman","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Amsterdam UMC, location Vrije Universiteit Amsterdam , Amsterdam ,","place":["the Netherlands"]},{"name":"Amsterdam Cardiovascular Sciences (ACS), Diabetes & Metabolism , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"2024110511212809200_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/j.semvascsurg.2021.02.010","article-title":"Epidemiology of end-stage kidney disease","volume":"34","author":"Gupta","year":"2021","journal-title":"Semin Vasc Surg"},{"key":"2024110511212809200_bib2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular disease in chronic kidney disease:\n pathophysiological insights and therapeutic options","volume":"143","author":"Jankowski","year":"2021","journal-title":"Circulation"},{"key":"2024110511212809200_bib3","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1681\/ASN.2016121341","article-title":"Chronic fluid overload and mortality in ESRD","volume":"28","author":"Zoccali","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2024110511212809200_bib4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.34067\/KID.0007452020","article-title":"Electrolyte changes in contemporary hemodialysis: a secondary\n analysis of the monitoring in dialysis (MiD) study","volume":"2","author":"Correa","year":"2021","journal-title":"Kidney360"},{"key":"2024110511212809200_bib5","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1681\/ASN.2014020222","article-title":"Association of mortality risk with various definitions of\n intradialytic hypotension","volume":"26","author":"Flythe","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2024110511212809200_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/hdi.12923","article-title":"Relationship of a food intake during hemodialysis and\n symptomatic intradialytic hypotension","volume":"25","author":"Jelicic","year":"2021","journal-title":"Hemodial\n Int"},{"key":"2024110511212809200_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/hdi.12138","article-title":"Intradialytic hypotension: frequency, sources of variation and\n correlation with clinical outcome","volume":"18","author":"Sands","year":"2014","journal-title":"Hemodial\n Int"},{"key":"2024110511212809200_bib8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/sdi.12627","article-title":"A brief review of intradialytic hypotension with a focus on\n survival","volume":"30","author":"Chou","year":"2017","journal-title":"Semin Dial"},{"key":"2024110511212809200_bib9","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2215\/CJN.12141017","article-title":"Mechanisms, clinical implications, and treatment of\n intradialytic hypotension","volume":"13","author":"Reeves","year":"2018","journal-title":"Clin J Am Soc\n Nephrol"},{"key":"2024110511212809200_bib10","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/ckj\/sfaa078","article-title":"An update review of intradialytic hypotension: concept, risk\n factors, clinical implications and management","volume":"13","author":"Kanbay","year":"2020","journal-title":"Clin\n Kidney J"},{"key":"2024110511212809200_bib11","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1681\/ASN.2016060704","article-title":"Relationship between hypotension and cerebral ischemia during\n hemodialysis","volume":"28","author":"MacEwen","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2024110511212809200_bib12","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1046\/j.1523-1755.2002.00505.x","article-title":"Predictors of the rate of decline of residual renal function\n in incident dialysis patients","volume":"62","author":"Jansen","year":"2002","journal-title":"Kidney Int"},{"key":"2024110511212809200_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/0886022X.2019.1603110","article-title":"High sensitivity troponin-I levels in asymptomatic hemodialysis\n patients","volume":"41","author":"Tarapan","year":"2019","journal-title":"Ren Fail"},{"key":"2024110511212809200_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/14017437909101788","article-title":"Serum CK-MB kinetics in acute myocardial infarction and after\n coronary bypass operations","volume":"13","author":"Str\u00f6m","year":"1979","journal-title":"Scand J Thorac\n Cardiovasc Surg"},{"key":"2024110511212809200_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular\n vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024110511212809200_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12020-012-9839-0","article-title":"Extracellular vesicles as an emerging mechanism of cell-to-cell\n communication","volume":"44","author":"Tetta","year":"2013","journal-title":"Endocrine"},{"key":"2024110511212809200_bib17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ki.2010.278","article-title":"Exosomes\/microvesicles as a mechanism of cell-to-cell\n communication","volume":"78","author":"Camussi","year":"2010","journal-title":"Kidney Int"},{"key":"2024110511212809200_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/toxins12120811","article-title":"Effects of chronic kidney disease and uremic toxins on\n extracellular vesicle biology","volume":"12","author":"Yaker","year":"2020","journal-title":"Toxins\n (Basel)"},{"key":"2024110511212809200_bib19","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1056\/NEJMra1704286","article-title":"Circulating extracellular vesicles in Human\n disease","volume":"379","author":"Shah","year":"2018","journal-title":"N Engl J Med"},{"key":"2024110511212809200_bib20","doi-asserted-by":"crossref","first-page":"11561","DOI":"10.1038\/s41598-017-10646-x","article-title":"Reproducible and scalable purification of extracellular vesicles\n using combined bind-elute and size exclusion chromatography","volume":"7","author":"Corso","year":"2017","journal-title":"Sci Rep"},{"key":"2024110511212809200_bib21","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/ndt\/gfv349","article-title":"Haemodiafiltration and mortality in end-stage kidney disease\n patients: a pooled individual participant data analysis from four randomized\n controlled trials","volume":"31","author":"Peters","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"2024110511212809200_bib22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/sdi.12200","article-title":"Clinical evidence on hemodiafiltration: a systematic review and a\n meta-analysis","volume":"27","author":"Mostovaya","year":"2014","journal-title":"Semin Dial"},{"key":"2024110511212809200_bib23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1056\/NEJMoa2304820","article-title":"Effect of hemodiafiltration or hemodialysis on mortality in\n kidney failure","volume":"389","author":"Blankestijn","year":"2023","journal-title":"N Engl J Med"},{"key":"2024110511212809200_bib24","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.ekir.2022.06.021","article-title":"High-volume hemodiafiltration and cool hemodialysis have a\n beneficial effect on intradialytic hemodynamics: a randomized cross-over\n trial of four intermittent dialysis strategies","volume":"7","author":"Rootjes","year":"2022","journal-title":"Kidney Int Rep"},{"key":"2024110511212809200_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12882-021-02331-z","article-title":"Effect of various dialysis modalities on intradialytic\n hemodynamics, tissue injury and patient discomfort in chronic dialysis\n patients: design of a randomized cross-over study (HOLLANT)","volume":"22","author":"Rootjes","year":"2021","journal-title":"BMC Nephrol"},{"key":"2024110511212809200_bib26","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1053\/j.ajkd.2015.07.015","article-title":"KDOQI\n Clinical Practice Guideline for Hemodialysis Adequacy: 2015\n update","volume":"66","author":"National Kidney F","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"2024110511212809200_bib27","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018\n (MISEV2018): a position statement of the International Society for\n Extracellular Vesicles and update of the MISEV2014\n guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"2024110511212809200_bib28","doi-asserted-by":"crossref","first-page":"1713526","DOI":"10.1080\/20013078.2020.1713526","article-title":"MIFlowCyt-EV: a framework for standardized reporting of\n extracellular vesicle flow cytometry experiments","volume":"9","author":"Welsh","year":"2020","journal-title":"J\n Extracell Vesicles"},{"key":"2024110511212809200_bib29","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1093\/ndt\/gfp308","article-title":"Post-dilution haemodiafiltration and low-flux haemodialysis have\n dissimilar effects on platelets: a side study of CONTRAST","volume":"24","author":"Gritters-van den\n Oever","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2024110511212809200_bib30","first-page":"548","article-title":"Mortality reduction by post-dilution online-haemodiafiltration: a\n cause-specific analysis","volume":"32","author":"Nube","year":"2017","journal-title":"Nephrol Dial\n Transplant"},{"key":"2024110511212809200_bib31","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ndt\/gfn501","article-title":"Haemodialysis is associated with a pronounced fall in myocardial\n perfusion","volume":"24","author":"Dasselaar","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2024110511212809200_bib32","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(22)01805-0","article-title":"Personalised cooler\n dialysate for patients receiving maintenance haemodialysis (MyTEMP): a\n pragmatic, cluster-randomised trial","volume":"400","year":"2022","journal-title":"Lancet"},{"key":"2024110511212809200_bib33","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1093\/ndt\/gfad003","article-title":"Effectiveness of cold HD for the prevention of HD hypotension and\n mortality in the general HD population","volume":"38","author":"Zoccali","year":"2023","journal-title":"Nephrol Dial\n Transplant"},{"key":"2024110511212809200_bib34","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(22)01988-2","article-title":"Evaluating the results of MyTEMP, a cluster randomised trial\n of lower temperature haemodialysis: the end of a cool idea?","volume":"400","author":"Selby","year":"2022","journal-title":"Lancet"},{"key":"2024110511212809200_bib35","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/ndt\/gfad054","article-title":"Cold haemodialysis: the instrumental power of large\n cohorts","volume":"38","author":"Combe","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"2024110511212809200_bib36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2215\/CJN.0000000000000355","article-title":"Survival benefit with hemodiafiltration: are we convinced,\n and if so, what might be the mechanism?","volume":"19","author":"Daugirdas","year":"2024","journal-title":"Clin J Am Soc Nephrol"},{"key":"2024110511212809200_bib37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/sj.ki.5002250","article-title":"Microinflammation induces endothelial damage in hemodialysis\n patients: the role of convective transport","volume":"72","author":"Ramirez","year":"2007","journal-title":"Kidney\n Int"},{"key":"2024110511212809200_bib38","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.4049\/jimmunol.1800747","article-title":"Online hemodiafiltration inhibits inflammation-related\n endothelial dysfunction and vascular calcification of uremic patients\n modulating miR-223 expression in plasma extracellular\n vesicles","volume":"202","author":"Cavallari","year":"2019","journal-title":"J Immunol"},{"key":"2024110511212809200_bib39","doi-asserted-by":"crossref","first-page":"e13825","DOI":"10.14814\/phy2.13825","article-title":"Exercise during hemodialysis does not affect the phenotype or\n prothrombotic nature of microparticles but alters their proinflammatory\n function","volume":"6","author":"Martin","year":"2018","journal-title":"Physiol Rep"},{"key":"2024110511212809200_bib40","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1538-7836.2005.01780.x","article-title":"Elevation of circulating endothelial microparticles in patients\n with chronic renal failure","volume":"4","author":"Faure","year":"2006","journal-title":"J Thromb\n Haemost"},{"key":"2024110511212809200_bib41","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/ckj\/sfy109","article-title":"Acute effects of haemodialysis on circulating\n microparticles","volume":"12","author":"de Laval","year":"2019","journal-title":"Clin Kidney J"},{"key":"2024110511212809200_bib42","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.HYP.0000259667.22309.df","article-title":"In vivo shear stress determines circulating levels of endothelial\n microparticles in end-stage renal disease","volume":"49","author":"Boulanger","year":"2007","journal-title":"Hypertension"},{"key":"2024110511212809200_bib43","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s12882-019-1459-y","article-title":"Effect of hemodialysis on extracellular vesicles and circulating\n submicron particles","volume":"20","author":"Ruzicka","year":"2019","journal-title":"BMC Nephrol"},{"key":"2024110511212809200_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1139\/cjpp-2017-0285","article-title":"Short-term effects of hemodiafiltration versus conventional\n hemodialysis on erythrocyte performance","volume":"96","author":"Georgatzakou","year":"2018","journal-title":"Can J\n Physiol Pharmacol"},{"key":"2024110511212809200_bib45","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/CIRCRESAHA.117.309417","article-title":"Methodological guidelines to study extracellular\n vesicles","volume":"120","author":"Coumans","year":"2017","journal-title":"Circ Res"},{"key":"2024110511212809200_bib46","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/jth.14009","article-title":"Standardization of extracellular vesicle measurements by flow\n cytometry through vesicle diameter approximation","volume":"16","author":"van der Pol","year":"2018","journal-title":"J\n Thromb Haemost"},{"key":"2024110511212809200_bib47","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s11255-020-02489-9","article-title":"High-volume online haemodiafiltration treatment and outcome\n of end-stage renal disease patients: more than one mode","volume":"52","author":"Schiffl","year":"2020","journal-title":"Int Urol Nephrol"},{"key":"2024110511212809200_bib48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000045671","article-title":"Hemodialysis-induced degranulation of polymorphonuclear cells: no\n correlation between membrane markers and degranulation\n products","volume":"85","author":"Grooteman","year":"2000","journal-title":"Nephron"},{"key":"2024110511212809200_bib49","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1681\/ASN.2018121194","article-title":"Renal perfusion during hemodialysis: intradialytic blood flow\n decline and effects of dialysate cooling","volume":"30","author":"Marants","year":"2019","journal-title":"J Am Soc\n Nephrol"},{"key":"2024110511212809200_bib50","doi-asserted-by":"crossref","first-page":"100348","DOI":"10.1016\/j.colcom.2020.100348","article-title":"Protein adsorption phenomena in hemodialysis membranes:\n mechanisms, influences of clinical practices, modeling, and\n challenges","volume":"40","author":"Westphalen","year":"2021","journal-title":"Colloids Interface Sci Commun"},{"key":"2024110511212809200_bib51","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/cpt.2865","article-title":"Kinetics of circulating extracellular vesicles over the 24-hour\n dosing interval after low-dose aspirin administration in patients at\n cardiovascular risk","volume":"113","author":"Liani","year":"2023","journal-title":"Clin Pharmacol Ther"},{"key":"2024110511212809200_bib52","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.kint.2021.01.018","article-title":"The time of onset of intradialytic hypotension during a\n hemodialysis session associates with clinical parameters and\n mortality","volume":"99","author":"Keane","year":"2021","journal-title":"Kidney Int"},{"key":"2024110511212809200_bib53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fimmu.2018.00071","article-title":"The Complement system in dialysis: a forgotten\n story?","volume":"9","author":"Poppelaars","year":"2018","journal-title":"Front Immunol"},{"key":"2024110511212809200_bib54","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2018.00721","article-title":"Extracellular vesicles: packages sent with\n complement","volume":"9","author":"Karasu","year":"2018","journal-title":"Front Immunol"},{"key":"2024110511212809200_bib55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.34067\/KID.0000342019","article-title":"Hemocompatibility of polysulfone hemodialyzers\u2014exploratory\n studies on impact of treatment modality and dialyzer\n characteristics","volume":"1","author":"Wagner","year":"2020","journal-title":"Kidney360"},{"key":"2024110511212809200_bib56","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1373\/clinchem.2017.278978","article-title":"Comparison of generic fluorescent markers for detection of\n extracellular vesicles by flow cytometry","volume":"64","author":"de Rond","year":"2018","journal-title":"Clin\n Chem"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfae134\/57356814\/sfae134.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/17\/6\/sfae134\/60422823\/sfae134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/17\/6\/sfae134\/60422823\/sfae134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:22:01Z","timestamp":1730805721000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/doi\/10.1093\/ckj\/sfae134\/7659835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfae134","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,4,29]]},"article-number":"sfae134"}}