{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:17:12Z","timestamp":1776885432599,"version":"3.51.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The anti-neutrophil cytoplasmic antibody (ANCA) renal risk score (ARRS) for predicting renal survival in ANCA-associated vasculitis (AAV) had not previously been validated in adults over 65 years of age and presenting impairments associated with an aging kidney, a high cardiovascular comorbidity burden, and prevalent microscopic polyangiitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively studied a cohort of 192 patients over 65 years of age (median [interquartile range] age: 73 [68; 78]), including 17.2% with renal-limited vasculitis, 49.5% with microscopic polyangiitis and 33.3% with granulomatosis with polyangiitis, at six centres of northern France. The primary study endpoint was the cumulative incidence of end-stage kidney disease (ESKD, maintenance of dialysis for at least 3 months) at 12 months, with death considered as a competing event.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median serum creatinine concentration at diagnosis was 300 [202; 502] \u00b5mol\/L, and 48 (25.0%) patients required dialysis at presentation. The ARRS was high in 43 (22.4%) patients, medium in 106 (55.2%), and low in 43 (22.4%). The cumulative incidence of ESKD at 12 months was 0% in the low-risk group, 13.0% [7.6\u201320.0] in the medium-risk group, and 44.0% [29.0\u201358.0] in the high-risk group (p\u00a0&amp;lt;\u00a00.001). In the subgroup of 149 patients presenting a medium or high score, the ARRS had a C-index of 0.66 [0.58\u20130.74] for the prediction of ESKD at 12 months; this rose to 0.86 [0.80\u20130.90] when dialysis status at diagnosis was included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The ARRS was a poor predictor of kidney survival at 12 months among patients over 65 years of age with renal AAV involvement\u2014especially in the high ARRS group. The addition of dialysis status at diagnosis as an additional clinical parameter might improve the ARRS's predictive performance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae135","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T02:46:10Z","timestamp":1714445170000},"source":"Crossref","is-referenced-by-count":2,"title":["The predictive performance of the ANCA renal risk score in patients over 65 years of age with renal ANCA-associated vasculitis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-9101","authenticated-orcid":false,"given":"Quentin","family":"de Berny","sequence":"first","affiliation":[{"name":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital , Amiens , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momar","family":"Diouf","sequence":"additional","affiliation":[{"name":"Clinical Research and Innovation Department, Amiens University Hospital , Amiens , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafik","family":"Mesbah","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Internal Medicine, Boulogne-sur-Mer Hospital , Boulogne sur Mer , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Quemeneur","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Internal Medicine, Valenciennes Hospital , Valenciennes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Lebas","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Lille University Hospital , Lille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-5785","authenticated-orcid":false,"given":"Dominique","family":"Guerrot","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, INSERM U1096, CHU Rouen, CIC-CRB 1404, Service de N\u00e9phrologie , Rouen , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Lille University Hospital , Lille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Baptiste","family":"Gibier","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pathology Institute, Lille University, Lille University Hospital , Lille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"Department of Pathology, Amiens University Hospital , Amiens , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Francois","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rouen University Hospital , Rouen , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Gueutin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Caen University Hospital , Caen , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Choukroun","sequence":"additional","affiliation":[{"name":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital , Amiens , France"},{"name":"MP3CV Research Unit, Jules Verne University of Picardie , Amiens , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-4193","authenticated-orcid":false,"given":"Dimitri","family":"Titeca-Beauport","sequence":"additional","affiliation":[{"name":"Department of Nephrology Dialysis Transplantation, Amiens University Hospital , Amiens , France"},{"name":"MP3CV Research Unit, Jules Verne University of Picardie , Amiens , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,29]]},"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfae135\/57356827\/sfae135.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfae135\/57356827\/sfae135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T02:46:11Z","timestamp":1714445171000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article\/doi\/10.1093\/ckj\/sfae135\/7659839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfae135","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"article-number":"sfae135"}}