{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:10:09Z","timestamp":1785190209898,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Astra Zeneca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with congestive heart failure (CHF) remains somewhat scarce. This study aimed to evaluate the prevalence of albuminuria in a cohort of patients with CHF, identify the independent factors associated with albuminuria and analyse the correlation with different congestion parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a subanalysis of the Spanish Cardiorenal Registry, in which we enrolled 864 outpatients with heart failure and a value of urinary albumin:creatinine ratio (UACR) at the first visit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median age was 74\u00a0years, 549 (63.5%) were male and 438 (50.7%) had a reduced left ventricular ejection fraction. A total of 350 patients (40.5%) had albuminuria. Among these patients, 386 (33.1%) had a UACR of 30\u2013300\u00a0mg\/g and 64 (7.4%) had a UACR &amp;gt;300\u00a0mg\/g. In order of importance, the independent variables associated with higher UACR were estimated glomerular filtration rate determined by the Chronic Kidney Disease Epidemiology Collaboration equation (R2\u00a0=\u00a057.6%), systolic blood pressure (R2\u00a0=\u00a021.1%), previous furosemide equivalent dose (FED; R2\u00a0=\u00a07.5%), antigen carbohydrate 125 (CA125; R2\u00a0=\u00a06.1%), diabetes mellitus (R2\u00a0=\u00a05.6%) and oedema (R2\u00a0=\u00a01.9%). The combined influence of oedema, elevated CA125 levels and the FED accounted for 15.5% of the model's variability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with chronic stable heart failure, the prevalence of albuminuria is high. The risk factors of albuminuria in this population are chronic kidney disease and hypertension. Congestion parameters are also associated with increased albuminuria.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae140","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T20:59:17Z","timestamp":1715720357000},"source":"Crossref","is-referenced-by-count":7,"title":["Congestion as a crucial factor determining albuminuria in patients with cardiorenal disease"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-0599","authenticated-orcid":false,"given":"Pau","family":"Ll\u00e0cer","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS , Madrid , Spain"},{"name":"Department of Medicine and Medical Specialties, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcala\u0301 , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cobo Marcos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda , Madrid , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Cardiovasculares , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8720-3999","authenticated-orcid":false,"given":"Rafael","family":"de la Espriella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario de Valencia , Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"Gay\u00e1n Ord\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biom\u00e8dica de Lleida , Lleida , 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