{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:35:54Z","timestamp":1773693354581,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The objective of this study was to describe kidney involvement in patients with myelodysplastic syndromes (MDS), their treatments, and outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a multicenter retrospective study in seven centers, identifying MDS patients with acute kidney injury (AKI), chronic kidney disease (CKD), and urine abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifteen patients developed a kidney disease 3 months after MDS diagnosis. Median urine protein-to-creatinine ratio was 1.9\u00a0g\/g, and median serum creatinine was 3.2\u00a0mg\/dL. Ten patients had AKI at presentation, and 12 had extra-renal symptoms. The renal diagnoses included anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), ANCA negative vasculitis, C3 glomerulonephritis, immune complex-mediated glomerulonephritis, polyarteritis nodosa, and IgA vasculitis. All patients but one received a specific treatment for the MDS-associated kidney injury. The effect of MDS treatment on kidney injury could be assessed in six patients treated with azacitidine, and renal function evolution was heterogenous. After a median follow-up of 14 months, four patients had CKD stage 3, five had CKD stage 4, and three had end stage kidney disease. On the other hand, three evolved to an acute myeloid leukemia and three died. Compared to 84 MDS controls, patients who had kidney involvement were younger, had a higher number of dysplasia lineages, and were more eligible to receive hypomethylating agents, but no survival difference was seen between the two groups. Compared to 265 AAV without MDS, the ten with MDS-associated pauci-immune vasculitis were older, ANCA serology was more frequently negative, and more cutaneous lesions were seen.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The spectrum of kidney injuries associated with MDS is mostly represented by vasculitis with glomerular involvement, and especially AAV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae185","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T01:14:03Z","timestamp":1718846043000},"source":"Crossref","is-referenced-by-count":6,"title":["Kidney involvement in myelodysplastic syndromes"],"prefix":"10.1093","volume":"17","author":[{"given":"Marie-Camille","family":"Lafargue","sequence":"first","affiliation":[{"name":"Department of Nephrology, Tenon's Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Duong Van Huyen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universit\u00e9 Paris Cit\u00e9, Necker's Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut G","family":"Rennke","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-5616","authenticated-orcid":false,"given":"Marie","family":"Essig","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Ambroise Par\u00e9, Boulogne-Billancourt, Universit\u00e9 Paris-Saclay , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-0372","authenticated-orcid":false,"given":"Micka\u00ebl","family":"Bobot","sequence":"additional","affiliation":[{"name":"Centre de N\u00e9phrologie et Transplantation R\u00e9nale, AP-HM, H\u00f4pital de la Conception, CHU de la Conception , Marseille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-1577","authenticated-orcid":false,"given":"No\u00e9mie","family":"Jourde-Chiche","sequence":"additional","affiliation":[{"name":"Centre de N\u00e9phrologie et Transplantation R\u00e9nale, AP-HM, H\u00f4pital de la Conception, CHU de la Conception , Marseille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Sakhi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Necker's Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9 , 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of Rennes, CHU Rennes, INSERM, EHESP, IRSET (Institut de recherche en sant\u00e9, environnement et travail) , UMR_S 1085, Rennes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Grobost","sequence":"additional","affiliation":[{"name":"CHU Estaing, M\u00e9decine interne , Clermont-Ferrand , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-1452","authenticated-orcid":false,"given":"Carole","family":"Philipponnet","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Department, University Hospital , Clermont-Ferrand , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Jeannel","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Strasbourg University Hospital , Strasbourg , 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