{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:15:09Z","timestamp":1787944509978,"version":"build-2784847793"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The role of proximal tubules (PTs), a major component of the renal tubular structure in the renal cortex, has been examined extensively. Along with its physiological role in the reabsorption of various molecules, including electrolytes, amino acids and monosaccharides, transcellular transport of different hormones and regulation of homeostasis, pathological events affecting PTs may underlie multiple disease states. PT hypertrophy or a hyperfunctioning state, despite being a compensatory mechanism at first in response to various stimuli or alterations at tubular transport proteins, have been shown to be critical pathophysiological events leading to multiple disorders, including diabetes mellitus, obesity, metabolic syndrome and congestive heart failure. Moreover, pharmacotherapeutic agents have primarily targeted PTs, including sodium\u2013glucose cotransporter 2, urate transporters and carbonic anhydrase enzymes. In this narrative review, we focus on the physiological role of PTs in healthy states and the current understanding of the PT pathologies leading to disease states and potential therapeutic targets.<\/jats:p>","DOI":"10.1093\/ckj\/sfae195","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T20:51:08Z","timestamp":1719348668000},"source":"Crossref","is-referenced-by-count":16,"title":["Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-0675","authenticated-orcid":false,"given":"Mehmet","family":"Kanbay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Ko\u00e7 University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidar","family":"Copur","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ko\u00e7 University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Guldan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Ko\u00e7 University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasin","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Ko\u00e7 University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Hatipoglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Internal Medicine, Ko\u00e7 University School of Medicine , Istanbul , 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