{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:05:28Z","timestamp":1793912728230,"version":"4.8.0"},"reference-count":161,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"publisher","award":["206\/UN3\/2021"],"award-info":[{"award-number":["206\/UN3\/2021"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Many kidney diseases are associated with proteinuria. Since proteinuria is independently associated with kidney function loss, anti-proteinuric medication, often in combination with dietary salt restriction, comprises a major cornerstone in the prevention of progressive kidney failure. Nevertheless, complete remission of proteinuria is very difficult to achieve, and most patients with persistent proteinuria slowly progress toward kidney failure. It is well-recognized that proteinuria leads to kidney inflammation and fibrosis via various mechanisms. Among others, complement activation at the apical side of the proximal tubular epithelial cells is suggested to play a crucial role as a cause of progressive loss of kidney function. However, hitherto limited attention is given to the pathophysiological role of tubular complement activation relative to glomerular complement activation. This review aims to summarize the evidence for tubular epithelial complement activation in proteinuric kidney diseases in relation to loss of kidney function.<\/jats:p>","DOI":"10.1093\/ckj\/sfae215","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T23:35:08Z","timestamp":1720654508000},"source":"Crossref","is-referenced-by-count":14,"title":["Apical tubular complement activation and the loss of kidney function in proteinuric kidney diseases"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-1345","authenticated-orcid":false,"given":"Firas F","family":"Alkaff","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"},{"name":"Division of Pharmacology and Therapy, Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa G M","family":"Lammerts","sequence":"additional","affiliation":[{"name":"Transplantation Immunology, Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R","family":"Daha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"van den Born","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department 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