{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:04:29Z","timestamp":1762643069961,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Monash Health Nephrology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Very low calorie diets (VLCDs) are an obesity treatment option in the general population, but their efficacy and safety in patients on haemodialysis (HD) is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prospective single arm study of VLCD in haemodialysis patients. All participants received 2.5\u20133.3\u00a0MJ\/day for 12\u00a0weeks. Weekly assessment of VLCD, pre- and post-dialysis weight, inter-dialytic weight gain, and blood electrolytes occurred for the first 4 weeks, then fortnightly for another 8 weeks. Linear mixed models compared the change in weight over time as well as biochemical outcomes including potassium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-two participants [nine home HD (HHD) and 13 satellite HD (SHD)] enrolled with 19 completing the 12-week intervention. Mean post-dialysis weight declined from 121.1\u00a0kg at baseline to 109.9 at week 12 resulting in average decline of 0.88\u00a0kg per week (95% C.I. 0.71, 1.05, P\u00a0&amp;lt;\u00a0.001) with 12-week mean percentage weight loss9.3% (SD 3.5). Mean post-dialysis body mass index declined from 40.9\u00a0kg\/m2 at baseline to 37.1\u00a0kg\/m2 at week 12 (95% C.I. 0.25, 0.35, P\u00a0&amp;lt;\u00a0.001). Serum potassium rose from week 1 to 3, stabilized during weeks 4 to 6, and fell from week 8, returning near baseline by week 12. Six of the nine (66.6%) HHD participants and seven of the 13 (70%) SHD participants had at least one episode of hyperkalaemia (K\u00a0&amp;gt;\u00a06\u00a0mmol\/l). There were no clinical changes in serum sodium, corrected calcium, or phosphate levels during the study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>VLCD with dietitian supervision was effective in producing significant weight reduction, with an acceptable safety profile in patients treated with haemodialysis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae217","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T01:07:37Z","timestamp":1721178457000},"source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of very low calorie diet in patients receiving haemodialysis therapy"],"prefix":"10.1093","volume":"17","author":[{"given":"Julie E","family":"Woods","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7285-7878","authenticated-orcid":false,"given":"Anne","family":"Snelson","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda A","family":"Leger","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Rio","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujatha","family":"Medara","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Medical Centre, Monash Health , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Medical Centre, Monash Health , Melbourne, 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