{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:25:26Z","timestamp":1783632326597,"version":"3.55.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>In people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD. This review provides an updated critical analysis of recent trial evidence on vitamin D therapy in people with CKD.<\/jats:p>","DOI":"10.1093\/ckj\/sfae227","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T02:41:29Z","timestamp":1721356889000},"source":"Crossref","is-referenced-by-count":15,"title":["Vitamin D therapy in chronic kidney disease: a critical appraisal of clinical trial evidence"],"prefix":"10.1093","volume":"17","author":[{"given":"Wing-Chi G","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Nephrology, Wollongong Hospital , Wollongong, New South Wales , Australia"},{"name":"Renal and Metabolic Division, The George Institute for Global Health , Sydney, New South Wales , Australia"},{"name":"Faculty of Medicine, University of New South Wales , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel D","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Royal Melbourne Hospital , Parkville, Victoria , Australia"},{"name":"Department of Medicine (RMH), University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil V","family":"Badve","sequence":"additional","affiliation":[{"name":"Renal and Metabolic Division, The George Institute for Global Health , Sydney, New South Wales , Australia"},{"name":"Faculty of Medicine, University of New South Wales , Sydney, New South Wales , Australia"},{"name":"Department of Nephrology, St George Hospital , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"2024080809162306400_bib1","first-page":"1","article-title":"KDIGO 2017 Clinical Practice guideline update for the diagnosis, evaluation, prevention, and 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