{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:53:55Z","timestamp":1789523635577,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fond de Recherche du Qu\u00e9bec\u2013Sant\u00e9"},{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007671","name":"Fondation du CHUM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In patients with acute kidney injury (AKI), fluid balance management often relies on the prescription and achievement of fluid removal using intermittent renal replacement therapy (IRRT). This study aimed to describe characteristics associated with the failure to achieve target fluid removal (FATFR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a retrospective cohort study including IRRT sessions of conventional duration (&amp;lt;5 hours) performed for AKI in the intensive care unit (ICU) from 2017 to 2022 at a tertiary academic center. FATFR-50% was defined as fluid removal of &amp;lt;50% of the prescribed target. Characteristics of patients and sessions, as well as outcomes at 90 days were collected. The causes of FATFR were manually adjudicated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 291 patients and 1280 IRRT sessions in the ICU were included. FATFR-50% occurred in 7.3% of sessions and 19.2% of patients had at least one session with FATFR-50% during the first week of IRRT. Sessions with FATFR-50% were characterized by a higher occurrence of intradialytic hypotension (24.2%\u00a0vs 60.2%, P\u00a0&amp;lt;\u00a0.001) and a higher planned fluid removal (6.19\u00a0vs 5.27\u00a0m\/kg\/h, P\u00a0=\u00a0.02). Multiple episodes of FATFR-50% were associated with a positive cumulative fluid balance (\u03b2 3876 (CI 2053\u20135899) P\u00a0&amp;lt;\u00a0.001). At 90-day follow-up, FATFR-50% during the first week after IRRT initiation was independently associated with fewer ICU- and hospital-free days, as well as with a higher risk of mortality (odds ratio 2.01 CI 1.04\u20133.89, P\u00a0=\u00a0.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>FATFR occurs in about one out of five critically ill patients within the first week of IRRT and is associated with adverse clinical outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae257","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:31:00Z","timestamp":1726047060000},"source":"Crossref","is-referenced-by-count":4,"title":["Achievement of fluid removal targets during intermittent renal replacement therapy in the intensive care unit"],"prefix":"10.1093","volume":"17","author":[{"given":"Michel","family":"Gouin","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Joyal","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Lamothe","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Yi","family":"Fan","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Huard","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-2670","authenticated-orcid":false,"given":"Jean-Maxime","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Service of Nephrology, Department of Medicine, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM) , Montreal, Quebec ,","place":["Canada"]},{"name":"Centre de recherche du CHUM (CR CHUM) , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A","family":"Neyra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, AL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Wald","sequence":"additional","affiliation":[{"name":"Division of Nephrology, St. Michael's Hospital, University of Toronto, Li Ka Shing Knowledge Institute , Toronto, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-8703","authenticated-orcid":false,"given":"William","family":"Beaubien-Souligny","sequence":"additional","affiliation":[{"name":"Service of Nephrology, Department of Medicine, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM) , Montreal, Quebec ,","place":["Canada"]},{"name":"Centre de recherche du CHUM (CR CHUM) , Montreal, Quebec 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