{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:16:46Z","timestamp":1791598606646,"version":"4.3.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sodium-glucose cotransporter 2 inhibitors (SGLT2i) lower ambulatory blood pressure (ABP) in patients with type 2 diabetes mellitus; whether the same holds true in diabetic kidney disease (DKD) is unknown. This information is critical to the knowledge of mechanisms of nephroprotection and safety of this therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicenter prospective study evaluates the changes in ABP after 12\u00a0weeks of dapagliflozin 10\u00a0mg\/day in a cohort of patients with type 2 DKD and glomerular filtration rate (GFR) &amp;gt;25\u00a0mL\/min\/1.73 m2. Primary endpoint was the change of nighttime systolic blood pressure (SBP). Changes of daytime SBP, prevalence of normal dipping (day\/night SBP ratio &amp;lt;0.9) and changes in ABP patterns, that is, sustained uncontrolled hypertension (SUCH), white coat uncontrolled hypertension (WUCH), masked uncontrolled hypertension (MUCH) and controlled hypertension (CH) were secondary endpoints.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eighty-three of 96 patients completed the study [age 68.7\u00a0\u00b1\u00a08.9 years, 73.5% males, GFR 49\u00a0\u00b1\u00a017\u00a0mL\/min\/1.73 m2, median albuminuria: 0.18 (interquartile range 0.10\u20130.38) g\/24\u00a0h]. After 12\u00a0weeks of dapagliflozin, nighttime SBP declined by \u22123.0\u00a0mmHg (95% confidence interval \u22125.2\/\u22120.8\u00a0mmHg; P\u00a0=\u00a0.010) with an improvement of nighttime SBP goal (&amp;lt;110\u00a0mmHg) from 18.0% to 27.0% (P\u00a0&amp;lt;\u00a0.001). Similarly, the prevalence of normal dipping increased (from 31.3% to 50.6%, P\u00a0=\u00a0.005). A decrease in daytime (\u22122.4\u00a0mmHg; P\u00a0=\u00a0.046) and office (\u22127.9\u00a0mmHg; P\u00a0=\u00a0.009) SBP was also found. The decline of ambulatory and office SBP was associated with increased prevalence of CH (from 6.0% to 18.0%) and significant improvement of SUCH, WUCH and MUCH (P\u00a0=\u00a0.009). Albuminuria decreased (P\u00a0&amp;lt;\u00a0.001), whereas eGFR did not change (P\u00a0=\u00a0.297). Urinary tract infection (4.2%) and acute kidney injury (3.6%) were the main causes of drop-out. Only one patient showed a drop of nighttime SBP below 90\u00a0mmHg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Dapagliflozin is associated with improvement in circadian blood pressure rhythm with no major safety signal related to excessive blood pressure decrease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae316","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T02:50:04Z","timestamp":1729219804000},"source":"Crossref","is-referenced-by-count":4,"title":["Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study"],"prefix":"10.1093","volume":"17","author":[{"given":"Silvio","family":"Borrelli","sequence":"first","affiliation":[{"name":"Unit of Nephrology, Dept of Advanced Medical and Surgery Sciences, University of 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