{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:04:45Z","timestamp":1782961485988,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K17259"],"award-info":[{"award-number":["20K17259"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K07727"],"award-info":[{"award-number":["23K07727"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The role of parathyroid gland (PTG) ultrasonography in the management of secondary hyperparathyroidism after the introduction of calcimimetics remains unclear. Recent investigations have prompted renewed interest in the use of PTG ultrasonography for assessing treatment resistance to calcimimetics and determining the optimal timing for surgical intervention. This study aimed to explore the hypothesis that the PTG volume correlates with the calcimimetic dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively observed outpatients undergoing haemodialysis at baseline and a 4-year follow-up. PTG volume was measured using ultrasonography between January and December 2017 and January and December 2021. We examined the association between baseline PTG volume and calcimimetic doses after 4\u00a0years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 121 patients {median age 64\u00a0years [interquartile range (IQR) 54\u201372]}, 71 had PTG nodules on ultrasonography and the median total PTG volume was 34\u00a0mm3 (IQR 0\u2013178). In the short dialysis vintage group, baseline parathyroid hormone levels tended to correlate with baseline calcimimetic doses; however, this trend was not observed in the extended dialysis vintage group. Baseline PTG volume correlated with the cinacalcet-equivalent calcimimetic dose (correlation coefficient 0.46; P\u00a0&amp;lt;\u00a0.001) after 4\u00a0years. The calcimimetic dose in the group with an estimated PTG volume &amp;gt;500\u00a0mm3 was \u224880\u00a0mg\/day higher than that in the non-PTG nodule group after 4\u00a0years. In multivariate linear regression analysis, PTG volume &amp;gt;500\u00a0mm3 was associated with a high calcimimetic dose at 4\u00a0years in all analysis models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Assessing PTG volume using ultrasonography may help predict high calcimimetic doses.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfae391","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T12:09:49Z","timestamp":1736597389000},"source":"Crossref","is-referenced-by-count":3,"title":["Parathyroid gland volume and treatment resistance in patients with secondary hyperparathyroidism: a 4-year retrospective cohort study"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-9434","authenticated-orcid":false,"given":"Kazuhiko","family":"Kato","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine , Tokyo ,","place":["Japan"]},{"name":"Division of Molecular Epidemiology, Jikei University School of Medicine , Tokyo ,","place":["Japan"]},{"name":"Department of Nephrology, Morishita Memorial Hospital , Kanagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-0301","authenticated-orcid":false,"given":"Akio","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Morishita","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Morishita Memorial Hospital , Kanagawa 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