{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:35:27Z","timestamp":1792802127633,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic kidney disease (CKD) is commonly associated with multifactorial neuromuscular impairments. Few studies have investigated CKD-induced changes in maximal voluntary force (MVF), and even fewer have longitudinal follow-up. The aim of this study is to investigate whether CKD progression modifies the relationship between skeletal muscle mass and force, and the prevalence of sarcopaenia and sarcopenic obesity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The data used were prospectively collected during routine check-ups in a network of nutritional centres in Mexico and retrospectively analysed. From a dataset of 5430 patients, we selected 1098 patients with available anthropometric, kidney function, handgrip and bioimpedance data. The relationship between appendicular skeletal muscle mass (ASM) and MVF was investigated using mixed models and adjusted for age, sex, body mass index, physical activity level and CKD aetiology. Sarcopaenia prevalence were tested across period of follow-up using the Cochran\u2013Mantel\u2013Haenzen for repeated measures and across CKD stages using the Chi-2 test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After normalization with ASM, MVF was higher in CKD G1\u2013G3 compared with G4 and G5 (P\u00a0\u2264\u00a0.001, Cohen's d\u00a0=\u00a00.270\u20130.576). Slopes between MVF and ASM were lower in CKD G3, G4 and G5 than in CKD G1\u2013G2 [\u20132.268 (\u20133.927, \u20130.609), P\u00a0=\u00a0.008; \u20132.694 (\u20134.593, \u20130.794), P\u00a0=\u00a0.006; \u20133.675 (\u20135.326, \u20131.725), P\u00a0&amp;lt;\u00a0.001, respectively]. The prevalence of sarcopaenia and sarcopaenic obesity did not differ across CKD stages, but recovery was most commonly observed in CKD G1\u2013G2. Slope analysis showed an independent interaction between the slopes of kidney function and ASM on MVF evolution over time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CKD negatively, progressively and independently affects the neuromuscular system, and force production is reduced for any given muscle mass as CKD progresses. While no association was found between CKD stage and prevalence of sarcopaenia, recovery was more frequent in the early CKD stages. These results suggest the importance of early rehabilitation programs to improve musculoskeletal health, quality of life and survival in CKD patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfaf036","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T01:47:41Z","timestamp":1738720061000},"source":"Crossref","is-referenced-by-count":6,"title":["Quality matters: chronic kidney disease progression is associated with reduced muscle strength independently of changes in skeletal muscle mass: an observational study"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-180X","authenticated-orcid":false,"given":"Antoine","family":"Chatrenet","sequence":"first","affiliation":[{"name":"APCoSS \u2013 Institute of Physical Education and Sports Sciences (IFEPSA), UCO , Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"de M\u00fcllenheim","sequence":"additional","affiliation":[{"name":"APCoSS \u2013 Institute of Physical Education and Sports Sciences (IFEPSA), UCO , Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Torreggiani","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie et Dialyse, Centre Hospitalier Le Mans , Le Mans ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Nava","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n Nutricional de Fresenius Kabi M\u00e9xico"},{"name":"Sociedad Mexicana de Estudios en Ciencias de la Salud S.C"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo Urbina","family":"Arronte","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n Nutricional de Fresenius Kabi M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abril Guti\u00e9rrez","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n Nutricional de Fresenius Kabi M\u00e9xico"},{"name":"Sociedad Mexicana de Estudios en Ciencias de la Salud S.C"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina Barbara","family":"Piccoli","sequence":"additional","affiliation":[{"name":"N\u00e9phrologie et Dialyse, Centre Hospitalier Le Mans , Le Mans ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"2025040309391124800_bib1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000523714","article-title":"Fatigability and the role of neuromuscular impairments in chronic kidney disease","volume":"53","author":"Gollie","year":"2022","journal-title":"Am J 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