{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:32:29Z","timestamp":1792715549430,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7212021"],"award-info":[{"award-number":["7212021"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the association between imaging findings and histopathological characteristics of parathyroid glands in patients with secondary hyperparathyroidism (SHPT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventy-four glands from 21 patients with SHPT who underwent parathyroidectomy were evaluated for their pathological characteristics. The detection rates of parathyroid glands using ultrasound (US) and 99Tc-MIBI-SPECT\/CT (MIBI) were compared. Glands were classified as either US-positive or US-negative, and MIBI-positive or MIBI-negative. Morphological and pathological differences between the positive and negative groups were systematically analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The detection rates for parathyroid glands were 71% with US, 65% with MIBI, and 82% when combining both methods. US and MIBI showed similar localization accuracy in SHPT (P\u00a0=\u00a0.38). MIBI-positive glands had significantly larger oxyphil nodules compared with MIBI-negative glands (area: 10.92\u00a0mm\u00b2 vs 3.09\u00a0mm\u00b2, P\u00a0&amp;lt;\u00a0.01; area proportion: 61%\u00a0vs 30%, P\u00a0=\u00a0.002), while no significant differences were found in chief nodules. The US-positive group had fewer and smaller chief nodules (number: 2\u00a0vs 9, P\u00a0=\u00a0.005; area: 1.53\u00a0mm\u00b2 vs 11.08\u00a0mm\u00b2, P\u00a0=\u00a0.033) and a higher percentage of oxyphil nodules (74%\u00a0vs 33%, P\u00a0=\u00a0.003) compared with the US-negative group. Thirteen glands undetected by both US and MIBI had smaller oxyphil nodule areas (3.59 vs 13.24\u00a0mm\u00b2) and lower oxyphil nodule area percentages (25%\u00a0vs 68%). These pathological features, including adipose infiltration, intra-gland haemorrhage, cyst formation, and calcification, showed no correlation with the gland's imaging results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>US and MIBI had similar value in preoperative localization of SHPT. Parathyroid glands with more and larger oxyphil nodules were more likely to be detected by both MIBI and US.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfaf040","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:43:46Z","timestamp":1739151826000},"source":"Crossref","is-referenced-by-count":6,"title":["Preoperative localization of parathyroid glands in secondary hyperparathyroidism: correlations between 99mTc-MIBI-SPECT\/CT, ultrasound, and pathological characteristics"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9788-7597","authenticated-orcid":false,"given":"Binghan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology, Beijing Tongren Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Tongren Hospital, Capital Medical University , Beijing ,","place":["China"]},{"name":"Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology , Beijing Tongren Hospital, Capital Medical University, Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University , Beijing ,","place":["China"]},{"name":"Key Laboratory of Otolaryngology \u2013 Head and Neck Surgery (Capital Medical University), Ministry of Education , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiang","family":"Du","sequence":"additional","affiliation":[{"name":"Emory University Rollins School of Public Health , Atlanta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9914-3629","authenticated-orcid":false,"given":"Guojuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Beijing Tongren Hospital, Capital Medical University , Beijing 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