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Its incidence has significantly increased over the past decade. Despite substantial morbidity and mortality, the pathogenesis of calciphylaxis remains poorly understood, and currently there are currently no approved treatments available. Diagnosis largely relies on clinical suspicion; skin biopsy may be useful but is not essential, particularly when biopsy risks outweigh benefits. Effective management requires a multidisciplinary approach. Current therapeutic strategies include controlling metabolic bone disease, substituting vitamin K antagonists with alternative anticoagulants, discontinuing calcium and vitamin D supplements, optimizing dialysis protocols, and considering sodium thiosulfate. Promising novel therapies are now emerging. These 10 tips aim to help clinicians avoid common pitfalls and deliver optimal care to patients with calciphylaxis.<\/jats:p>","DOI":"10.1093\/ckj\/sfaf098","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:23:01Z","timestamp":1744255381000},"source":"Crossref","is-referenced-by-count":4,"title":["Ten tips on how to deal with calciphylaxis patients"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-9988","authenticated-orcid":false,"given":"Api","family":"Chewcharat","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital Division of Nephrology, Department of Medicine, , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar U","family":"Nigwekar","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Division of Nephrology, Department of Medicine, , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"2025042505013432900_bib1","doi-asserted-by":"publisher","first-page":"S724","DOI":"10.1007\/s11606-014-2910-1","article-title":"Quantifying a rare disease in administrative data: the example of calciphylaxis","volume":"29 Suppl 3","author":"Nigwekar","year":"2014","journal-title":"J Gen Intern Med"},{"key":"2025042505013432900_bib2","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.ekir.2024.01.026","article-title":"Calciphylaxis episodes in the Australia and New Zealand dialysis and transplant registry","volume":"9","author":"Toussaint","year":"2024","journal-title":"Kidney Int Rep"},{"key":"2025042505013432900_bib3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s10157-013-0782-z","article-title":"Calciphylaxis: diagnosis and clinical features","volume":"17","author":"Hayashi","year":"2013","journal-title":"Clin Exp Nephrol"},{"key":"2025042505013432900_bib4","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1056\/NEJMra1505292","article-title":"Calciphylaxis","volume":"378","author":"Nigwekar","year":"2018","journal-title":". 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