{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:52:34Z","timestamp":1789750354031,"version":"4.0.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["#2020-2712"],"award-info":[{"award-number":["#2020-2712"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contrast-associated acute kidney injury (CA-AKI) has been reported to occur in a significant proportion of patients undergoing percutaneous coronary intervention (PCI). The role of remote ischemic preconditioning (RIPC) in CA-AKI prevention remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center double-blind randomized controlled trial, 420 eligible patients with high risk of CA-AKI admitted for PCI were randomized into two groups: RIPC and sham RIPC (control group). RIPC was performed by repeated cycles of inflation and deflation of an upper limb blood pressure cuff prior to PCI. Serum neutrophil gelatinase-associated lipocalin (NGAL) levels were measured at 2- and 6-h, and serum creatinine at 24- and 48-h post-PCI. The primary endpoint was the incidence of CA-AKI. Secondary endpoints were change in serum creatinine at 48 h, incidence of subclinical AKI (defined as an increase in NGAL values by 25% or more from baseline), change in NGAL at 2- and 6-h (delta NGAL), in-hospital mortality and major adverse cardiovascular events (MACE) at Day 30.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CA-AKI occurred in 11.4% (n\u00a0=\u00a048), with AKI stage 1 in 10.2% (n\u00a0=\u00a042). The incidence of CA-AKI was significantly lower in the RIPC group, compared with control group [8.1% vs 15.0%, risk ratio (RR) 0.54, 95% confidence interval (CI) 0.31\u20130.94; P\u00a0=\u00a0.027]. There was no significant difference in change in creatinine at 48 h in both the groups (P\u00a0=\u00a0.158). The incidence of subclinical AKI was also numerically lower in the RIPC group; however, this was not statistically significant (36.2% vs 40.5%, RR 0.89, 95% CI 0.66\u20131.22; P\u00a0=\u00a0.158). Dialysis-requiring AKI, in-hospital mortality and 30-day MACE were similar in both groups. There were no RIPC-related adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients at high risk of developing CA-AKI after PCI, RIPC is an effective and safe preventive measure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfaf342","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:02:26Z","timestamp":1762434146000},"source":"Crossref","is-referenced-by-count":3,"title":["Remote ischemic preconditioning for prevention of contrast-associated acute kidney injury following percutaneous coronary intervention: a randomized controlled trial"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-3665","authenticated-orcid":false,"given":"Ganesh","family":"Paramasivam","sequence":"first","affiliation":[{"name":"Kasturba Medical College, Manipal, Manipal Academy of Higher 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,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Maradi","sequence":"additional","affiliation":[{"name":"Kasturba Medical College, Manipal, Manipal Academy of Higher Education Department of Biochemistry, , Manipal, Karnataka ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar Prasad","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Kasturba Medical College, Manipal, Manipal Academy of Higher Education Department of Nephrology, , Manipal, Karnataka ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmakumar","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Kasturba Medical College, Manipal, Manipal Academy of Higher Education Department of Cardiology, , Manipal, Karnataka 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