{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:21:22Z","timestamp":1793024482848,"version":"4.5.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic kidney disease (CKD) is a major global health problem and an important driver of cardiovascular morbidity and mortality. Sleep disorders are highly prevalent in people with, or at risk of, CKD, but their specific contribution to CKD onset and progression has not been clearly defined. Unlike previous reviews that have focused mainly on symptom burden, quality of life, or general management of sleep problems in CKD, this narrative review is explicitly centred on renal outcomes. We examine whether common sleep disorders\u2014insomnia, abnormal sleep duration, restless legs syndrome, periodic limb movement disorder, and obstructive sleep apnoea (OSA) and central sleep apnoea\u2014are associated with an increased risk of incident CKD and with faster progression of established CKD [estimated glomerular filtration rate (eGFR) decline, albuminuria, end\u2013stage kidney disease]. We synthesize evidence from prospective cohorts, administrative databases, and Mendelian randomization studies, with particular attention to residual confounding, incomplete sleep phenotyping, and overlap between sleep disorders, especially unrecognized OSA. Observational data suggest that poor sleep quality and abnormal sleep duration are modestly associated with incident CKD and CKD progression, although independence from OSA remains uncertain. In contrast, evidence linking OSA to reduced eGFR, albuminuria, and accelerated CKD progression is more consistent, and bidirectional relations between CKD and OSA are increasingly recognized. We also review pathophysiological pathways that plausibly connect sleep disorders to renal injury and critically appraise preliminary interventional data on OSA treatment and kidney outcomes. Finally, we outline the clinical implications of integrating outcome\u2013oriented sleep assessment into nephrology and hypertension care and propose a research agenda to determine whether systematic detection and treatment of sleep disorders, particularly OSA, should be adopted as a strategy to prevent CKD onset and slow CKD progression.<\/jats:p>","DOI":"10.1093\/ckj\/sfag098","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:47:49Z","timestamp":1774010869000},"source":"Crossref","is-referenced-by-count":2,"title":["The role of sleep disorders in the risk for CKD and CKD progression"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-1996","authenticated-orcid":false,"given":"Carmine","family":"Zoccali","sequence":"first","affiliation":[{"name":"Renal Research Institute , NY ,","place":["USA"]},{"name":"Institute of Molecular Biology and Genetics (Biogem) , Ariano Irpino ,","place":["Italy"]},{"name":"Associazione Ipertensione Nefrologia Trapianto Renal (IPNET), c\/o Nefrologia, Grande Ospedale Metropolitano , Reggio Calabria ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mallamaci","sequence":"additional","affiliation":[{"name":"Associazione Ipertensione Nefrologia Trapianto Renal (IPNET), c\/o Nefrologia, Grande Ospedale Metropolitano , Reggio Calabria ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kanbay","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Koc University School of Medicine Department of Internal Medicine, , \u00a0Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[{"name":"University of Milan Bicocca Department of Medicine and Surgery, , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mancia","sequence":"additional","affiliation":[{"name":"University of Milano-Bicocca (Emeritus Professor) , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"2026042108113818700_bib1","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.kint.2019.07.012","article-title":"A single number for advocacy and communication\u2014Worldwide more than 850 million individuals have kidney diseases","volume":"96","author":"Jager","year":"2019","journal-title":"Kidney Int"},{"key":"2026042108113818700_bib2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the global burden of disease study 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