{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:56:48Z","timestamp":1777910208288,"version":"3.51.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"DOI":"10.1093\/ckj\/sfag109","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:50:55Z","timestamp":1775217055000},"source":"Crossref","is-referenced-by-count":0,"title":["Levetiracetam-associated high\u2013anion gap metabolic acidosis and secondary ketogenesis: a case series"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8425-1984","authenticated-orcid":false,"given":"Khaled","family":"Al-Baqain","sequence":"first","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Sharawi","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Khabbaz","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Ghishan","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanal","family":"Ash-Shawareb","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murad","family":"Kheetan","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Shweihat","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeid","family":"Khitan","sequence":"additional","affiliation":[{"name":"Marshall University Joan C. Edwards School of Medicine Department of Internal Medicine, , Huntington, WV ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"2026050110511381400_bib1","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.12688\/f1000research.7006.1","article-title":"Drug-induced metabolic acidosis","volume":"4","author":"Pham","year":"2015","journal-title":"F1000Research"},{"key":"2026050110511381400_bib2","doi-asserted-by":"publisher","first-page":"707","DOI":"10.2165\/00003088-200443110-00002","article-title":"Clinical pharmacokinetics of levetiracetam","volume":"43","author":"Patsalos","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"2026050110511381400_bib3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.clinbiochem.2009.11.008","article-title":"Simultaneous determination of levetiracetam and its acid metabolite (ucb L057) by LC","volume":"43","author":"Mendu","year":"2010","journal-title":"Clin Biochem"},{"key":"2026050110511381400_bib4","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.3390\/app12031208","article-title":"Pharmacokinetics of levetiracetam in critically ill adult intensive care patients","volume":"12","author":"Markantonis","year":"2022","journal-title":"Appl Sci"},{"key":"2026050110511381400_bib5","first-page":"668","article-title":"High anion gap metabolic acidosis (HAGMA) after levetiracetam administration in an 11-year-old boy with laminin-\u03b12-deficiency-associated muscular dystrophy and epilepsy","volume":"30","author":"Beusker","year":"2025","journal-title":"J Pediatr Pharmacol Ther"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfag109\/67872082\/sfag109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/19\/5\/sfag109\/67872082\/sfag109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/article-pdf\/19\/5\/sfag109\/67872082\/sfag109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:51:16Z","timestamp":1777647076000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/doi\/10.1093\/ckj\/sfag109\/8607825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfag109","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,4,6]]},"article-number":"sfag109"}}