{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:26:43Z","timestamp":1792499203432,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We introduce the European Union consensus report on the diagnosis and treatment of monoclonal gammopathy of renal significance (MGRS), a generic term to describe kidney disorders caused by a non-malignant monoclonal immunoglobulin clone. There are many subtypes of MGRS, with AL-amyloidosis being most prevalent. The consensus report aims at providing guidance to clinicians, pathologists and laboratory specialists who take care of patients with a (suspected) diagnosis of MGRS. This executive summary provides a condensed overview of the most important aspects of the diagnosis and management of patients with MGRS. Consultation of expert centers is strongly advised. Although most patients will benefit from hematological, clone-directed therapy, treatment decisions must be individualized, in view of the heterogeneity of patients between and within the MGRS subtypes. The final chapter discusses kidney transplantation in patients with MGRS. The working group acknowledges that most advice is based on low-quality evidence. The full report provides the rationale and a detailed discussion of the available literature. This executive summary is an introduction, and not a substitute for the full consensus report.<\/jats:p>","DOI":"10.1093\/ckj\/sfag163","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:43:49Z","timestamp":1779277429000},"source":"Crossref","is-referenced-by-count":2,"title":["Executive summary of the European consensus report on the diagnosis and treatment of monoclonal gammopathy of renal significance"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-9675","authenticated-orcid":false,"given":"Ben","family":"Sprangers","sequence":"first","affiliation":[{"name":"Department of Nephrology, Ziekenhuis Oost-Limburg, Genk, Belgium, and Department of Immunology and Infection, Biomedical Research Institute, UHasselt , Diepenbeek ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, APHP, H\u00f4pital Bichat , Paris ,","place":["France"]},{"name":"Center for Inflammation Research (CRI), INSERM U1149, University de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Gnemmi","sequence":"additional","affiliation":[{"name":"Department of Pathology , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Shabaka","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz. IdiPAz , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Fernandez-Juarez","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz. IdiPAz , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"van\u00a0Midden","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboudumc Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Steenbergen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboudumc Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Pavia , Pavia ,","place":["Italy"]},{"name":"Amyloidosis Research and Treatment Center, Foundation \u201cIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo\u201d ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Vignon","sequence":"additional","affiliation":[{"name":"Hopital Cochin, APHP , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Wilde","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital Essen, University Duisburg-Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Hegenbart","sequence":"additional","affiliation":[{"name":"University Hospital, Amyloidosis Center , Heidelberg","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack F","family":"Wetzels","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026062206115824600_bib1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41581-018-0077-4","article-title":"The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group","volume":"15","author":"Leung","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2026062206115824600_bib2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.kint.2025.04.007","article-title":"Renal Pathology Society\/International Kidney and Monoclonal Gammopathy Research Group consensus on pathologic definitions and terminology of monoclonal gammopathy-associated kidney lesions","volume":"108","author":"Nasr","year":"2025","journal-title":"Kidney Int"},{"key":"2026062206115824600_bib3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/bjh.19956","article-title":"Diagnosis and management of monoclonal gammopathy of renal significance: a British Society for Haematology good practice paper","volume":"206","author":"Pinney","year":"2025","journal-title":"Br J Haematol"},{"key":"2026062206115824600_bib4","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1681\/ASN.2017121319","article-title":"D\u2019Agati VD. 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