{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:06:43Z","timestamp":1779379603323,"version":"3.53.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with diabetic kidney disease (DKD) face a substantially higher risk of premature death compared to non-diabetic counterparts, yet accurate biomarkers for stratifying this mortality risk beyond conventional kidney function measures are currently lacking. We investigated whether urinary angiotensinogen (UAGT), reflecting intrarenal renin-angiotensin-aldosterone system activity, predicts all-cause mortality differently among patients with versus without diabetes in chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included 824 propensity score-matched patients (412 with diabetes, 412 without diabetes) from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. Participants were categorized into quintiles by baseline urinary angiotensinogen-to-creatinine ratio (UAGT\/Cr). Cox proportional hazards models estimated adjusted hazard ratios (HRs) for all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During median follow-up of 8.9 years, 149 deaths occurred. In patients with diabetes, the highest UAGT\/Cr quintile was independently associated with increased mortality compared to the reference quintile (adjusted HR 3.61, 95% confidence interval 1.67-7.81, P&amp;lt;0.001) after adjustment for kidney function, proteinuria, and comorbidities. Penalized spline analysis demonstrated a monotonic relationship between UAGT\/Cr and mortality in patients with diabetes. In contrast, no significant association was observed in patients without diabetes (P for interaction &amp;lt;0.001). Findings remained robust in sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UAGT\/Cr independently predicts all-cause mortality specifically in CKD patients with diabetes but not in those without diabetes, suggesting its potential utility as an etiology-specific prognostic biomarker for risk stratification in diabetic kidney disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfag165","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:43:50Z","timestamp":1779277430000},"source":"Crossref","is-referenced-by-count":0,"title":["Urinary Angiotensinogen as a Novel Mortality Predictor in Diabetic Kidney Disease: A Propensity-Matched Analysis from the KNOW-CKD"],"prefix":"10.1093","author":[{"given":"Sang","family":"Heon Suh","sequence":"first","affiliation":[{"name":"Chonnam National University Medical School Department of Internal Medicine, , Gwangju ,","place":["Korea"]},{"name":"Chonnam National University Hospital Department of Internal Medicine, , Gwangju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University Department of Intelligent Electronics and Computer Engineering, , Gwangju ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Sang","family":"Choi","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School Department of Internal Medicine, , Gwangju ,","place":["Korea"]},{"name":"Chonnam National University Hospital Department of Internal Medicine, , Gwangju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Seong","family":"Kim","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School Department of Internal Medicine, , Gwangju ,","place":["Korea"]},{"name":"Chonnam National University Hospital Department of Internal Medicine, , Gwangju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hui","family":"Bae","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School Department of Internal Medicine, , Gwangju ,","place":["Korea"]},{"name":"Chonnam National University Hospital Department of Internal Medicine, , Gwangju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Kwon","family":"Ma","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School Department of Internal Medicine, , Gwangju ,","place":["Korea"]},{"name":"Chonnam National University Hospital Department of Internal Medicine, , Gwangju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-2179","authenticated-orcid":false,"given":"Kook-Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital Department of Internal Medicine, , Seoul ,","place":["Korea"]},{"name":"Kidney Research Institute, Seoul National University Medical Research Center , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-9004","authenticated-orcid":false,"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"Chonnam National University Medical School Department of Internal Medicine, , Gwangju ,","place":["Korea"]},{"name":"Chonnam National University Hospital Department of Internal Medicine, , Gwangju ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,21]]},"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfag165\/68358938\/sfag165.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article-pdf\/doi\/10.1093\/ckj\/sfag165\/68358938\/sfag165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:27:26Z","timestamp":1779377246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/advance-article\/doi\/10.1093\/ckj\/sfag165\/8689936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfag165","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"article-number":"sfag165"}}