{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:48:14Z","timestamp":1782920894561,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ELSAN"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many factors contribute to muscle impairment during chronic kidney disease, among which vitamin D deficiency has been implicated. The aim of this study was to analyze whether cholecalciferol supplementation in hemodialysis patients with low 25-hydroxyvitamin vitamin D (25OHD) concentrations could improve handgrip strength (HGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>VITADIAL (Does Correction of 25 OH-VITAmin D With Cholecalciferol Supplementation Increase Muscle Strength in HemoDIALysis Patients?) is a prospective open-labeled French multicenter study in which chronic hemodialysis patients with a 25OHD \u226450 nmol\/L were randomized to receive monthly oral 100\u00a0000 IU cholecalciferol or no vitamin D treatment during 6 months to assess whether cholecalciferol supplementation in vitamin D\u2013deficient hemodialysis patients improves muscle strength as measured with HGS. The main objective of the study was to analyze whether a 6-month period of oral cholecalciferol improved the muscle strength of hemodialysis patients with low 25OHD levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within the 270 hemodialysis patients from 10 hemodialysis centers included in the study, 143 patients with 25OHD \u226450 nmol\/L were randomized: 70 were allocated to the cholecalciferol group and 73 to the control group. The two groups were comparable at inclusion. The cholecalciferol supplemented group's 25OHD rose to 89.78\u00a0\u00b1\u00a033.43 nmol\/L at 6 months and remained \u226450 nmol\/L for most patients in the control group, but HGS did not change significantly between randomization and end of the study in both groups (0.07\u00a0\u00b1\u00a03.40 kg and \u20130.19\u00a0\u00b1\u00a03.35 kg, respectively, P-value .682). No difference was found in terms of either autonomy or frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This highly powered study did not find any effect of cholecalciferol supplementation in muscle strength of hemodialysis patients with low 25OHD.<\/jats:p>\n                    <jats:p>Trial registration: ClinicalTrials, NCT04262934. Registered 10 February 2020. Retrospectively registered, https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04262934<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfag166","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:44:34Z","timestamp":1779363874000},"source":"Crossref","is-referenced-by-count":0,"title":["Cholecalciferol and muscle strength in hemodialysis patients: results from the randomized VITADIAL trial"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8344-1300","authenticated-orcid":false,"given":"Stanislas","family":"Bataille","sequence":"first","affiliation":[{"name":"Phocean Institute of Nephrology, Nephrology Department, 13006 , Marseille ,","place":["France"]},{"name":"ELSAN, Clinique Bouchard, Nephrology Department , Marseille 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