{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:23:14Z","timestamp":1787354594766,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["RS-2025-16071434"],"award-info":[{"award-number":["RS-2025-16071434"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High peritoneal transport status has traditionally been linked to adverse outcomes in peritoneal dialysis (PD). However, its clinical relevance in contemporary, individualized PD practice remains unclear. We therefore evaluated its association with long-term outcomes across three successive treatment eras.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 473 incident PD patients treated between 2000 and 2024, grouped into three treatment eras reflecting major changes in PD practice. Baseline peritoneal transport status was defined by the 4-h dialysate-to-plasma creatinine ratio and categorized as high or non-high. The primary outcome was technique failure. Fine-Gray competing-risk models were used to assess technique failure and all-cause mortality, including transport-by-era interaction terms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of these, 114 (24.1%) were classified as high transporters. In the earliest era, high transport status was associated with nearly two-fold higher crude technique failure rates than non-high status, but this difference narrowed over time and was minimal in the most recent era. In fully adjusted competing-risk models, high transport status was not independently associated with technique failure; instead, more recent treatment era and higher serum albumin were associated with a lower risk of technique failure. A significant transport-by-era interaction suggested attenuation of the adverse prognostic impact of high transport status in contemporary practice (P for interaction\u00a0=\u00a0.044). More recent treatment era was also associated with lower all-cause mortality, whereas the transport-by-era interaction was not significant for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prognostic significance of high peritoneal transport status appears to be era-dependent and less pronounced in contemporary PD practice. These findings suggest that PET-derived transport status may be better interpreted as a guide for individualized PD prescription rather than as a fixed predictor of adverse outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfag214","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:56:17Z","timestamp":1782302177000},"source":"Crossref","is-referenced-by-count":0,"title":["Changing prognostic significance of peritoneal transport status in contemporary incident peritoneal dialysis patients"],"prefix":"10.1093","volume":"19","author":[{"given":"Ho-Joong","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital , Anyang ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sion","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics and Institute of Statistics, Hallym University , Chuncheon ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital , Anyang ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital , Anyang ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-2143","authenticated-orcid":false,"given":"Jwa-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital , Anyang ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2026082118270220100_bib1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/0896860819895364","article-title":"International Society for Peritoneal Dialysis practice recommendations: prescribing high-quality goal-directed peritoneal dialysis","volume":"40","author":"Brown","year":"2020","journal-title":"Perit Dial Int"},{"key":"2026082118270220100_bib2","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41581-022-00623-7","article-title":"Epidemiology of peritoneal dialysis outcomes","volume":"18","author":"Bello","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"2026082118270220100_bib3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nrneph.2016.181","article-title":"Changes in the worldwide epidemiology of peritoneal dialysis","volume":"13","author":"Li","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2026082118270220100_bib4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2362.1987.tb01224.x","article-title":"Arisz L; Alterations in the peritoneal transport of water and solutes during peritonitis in continuous ambulatory peritoneal dialysis patients","volume":"17","author":"Krediet","year":"1987","journal-title":"Eur J Clin Invest"},{"key":"2026082118270220100_bib5","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1177\/0896860820982218","article-title":"ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: classification, measurement, interpretation and rationale for intervention","volume":"41","author":"Morelle","year":"2021","journal-title":"Perit Dial Int"},{"key":"2026082118270220100_bib6","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1681\/ASN.V971285","article-title":"Increased peritoneal membrane transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients. 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