{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:48:04Z","timestamp":1785750484501,"version":"3.56.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) is a frequent complication in patients with cancer. Although AKI in oncology is often multifactorial, it is frequently attributed to nephrotoxicity or intrinsic tubular injury. However, its hemodynamic mechanisms remain underrecognized. Accumulating evidence from critical care and cardiorenal medicine indicates that fluid overload, venous congestion, and increased intra-abdominal pressure are major drivers of kidney dysfunction and adverse outcomes in patients with cancer. These mechanisms are particularly relevant in onco-hematology, where protocol-driven hydration, transfusions, systemic inflammation, and capillary leak are common. This review examines venous congestion as an underrecognized and potentially reversible contributor to AKI in patients with cancer, by integrating epidemiological data, mechanistic insights, and clinical evidence. Particular emphasis is placed on the distinction between fluid responsiveness (FR) and fluid tolerance (FT), with the reviewed studies suggesting that many patients with AKI are neither fluid responsive nor fluid tolerant and that these phenotypes evolve dynamically over time. Tumor lysis syndrome is presented as a paradigmatic clinical scenario in which aggressive hydration is widely recommended despite limited high-quality evidence and a substantial risk of fluid intolerance. We further describe the role of point-of-care ultrasound in the bedside assessment of cardiac filling pressures, venous congestion, and stroke volume, and propose a physiology-based framework for AKI evaluation that prioritizes exclusion of urinary tract obstruction, systematic assessment of FT, and selective evaluation of FR in hypotensive or low-flow states. Adopting this approach may help individualize fluid management, reduce iatrogenic harm, and improve renal outcomes in patients with cancer.<\/jats:p>","DOI":"10.1093\/ckj\/sfag232","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:38:49Z","timestamp":1783856329000},"source":"Crossref","is-referenced-by-count":0,"title":["Drowning the kidneys: from fluid overload to physiology-guided fluid management in onco-hematology"],"prefix":"10.1093","volume":"19","author":[{"given":"Fernando","family":"Parra-Londo\u00f1o","sequence":"first","affiliation":[{"name":"Nephrology Department, Germans Trias i Pujol University Hospital , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Urrutia-Jou","sequence":"additional","affiliation":[{"name":"Nephrology Department, Germans Trias i Pujol University Hospital , Badalona ,","place":["Spain"]},{"name":"REMAR-IGTP Group, Germans Trias i Pujol Research 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,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Nephrology Department, Germans Trias i Pujol University Hospital , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Nassiri-Nassiri","sequence":"additional","affiliation":[{"name":"Nephrology Department, Germans Trias i Pujol University Hospital , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristhian Paul","family":"Cede\u00f1o-Parra","sequence":"additional","affiliation":[{"name":"Hematology Department, ICO Badalona \u2013 Germans Trias i Pujol University Hospital, Institut de Recerca Josep Carreras , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Buccione","sequence":"additional","affiliation":[{"name":"Unitat Hospitalitzaci\u00f3 Oncol\u00f2gica i Unitat d\u2019Atenci\u00f3 Continuada Oncol\u00f2gica, Institut Catal\u00e0 d\u2019Oncologia , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"Rodr\u00edguez-Chitiva","sequence":"additional","affiliation":[{"name":"Nephrology Department, Germans Trias i Pujol University Hospital , Badalona ,","place":["Spain"]},{"name":"REMAR-IGTP Group, Germans Trias i Pujol Research Institute, Can Ruti Campus , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vives","sequence":"additional","affiliation":[{"name":"Hematology Department, ICO Badalona \u2013 Germans Trias i Pujol University Hospital, Institut de Recerca Josep Carreras , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Tudela","sequence":"additional","affiliation":[{"name":"Unitat Hospitalitzaci\u00f3 Oncol\u00f2gica i Unitat d\u2019Atenci\u00f3 Continuada Oncol\u00f2gica, Institut Catal\u00e0 d\u2019Oncologia , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-2459","authenticated-orcid":false,"given":"Javier A","family":"Neyra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, AL, 35294 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-5052","authenticated-orcid":false,"given":"Faeq","family":"Husain-Syed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3621-0766","authenticated-orcid":false,"given":"Mar\u00eda 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