{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:57:48Z","timestamp":1790841468370,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020867","name":"Montreal Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The tight junction family of claudin proteins regulates paracellular ion transport in the nephron and across epithelial and endothelial barriers throughout the body. Rare recessive variants in CLDN16\u00a0and CLDN19 cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), while common variants in CLDN2, CLDN10, and CLDN14 have been associated with kidney stones. Despite evidence that most claudin proteins are expressed within the nephron, their genetic contribution to kidney stone susceptibility has not been systematically explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 415\u2009237 UK Biobank participants (9009 kidney stone cases and 406\u2009228 controls) using exome sequencing and imputed genotype data spanning all 24 human CLDN genes. Single-variant association testing, gene burden analysis, and phenome-wide association studies were employed to identify novel associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-three novel coding variant associations were identified through exome sequencing, including two CLDN16 variants: p.Gly57Arg (rs747654138; odds ratio [OR]\u2009=\u200942.2,\u00a0P\u00a0=\u20099.5\u2009\u00d7\u200910\u22128) and p.Arg146His (rs772241737; OR\u2009=\u200960.5,\u00a0P\u00a0=\u00a08.1\u2009\u00d7\u200910\u22124). We replicated a known association with a CLDN19 variant, p.Arg200Gln (rs116804195; OR\u2009=\u20091.23, P\u00a0=\u20092.6\u2009\u00d7\u200910\u22124), which was also associated with decreased serum phosphate and increased alkaline phosphatase. We also identified 13 novel susceptibility loci within the imputed genotype dataset, including single nucleotide polymorphisms near CLDN2, CLDN10, CLDN11, CLDN18, and CLDN22\u2013CLDN24 (all P\u00a0&amp;lt;\u20090.00025), and confirmed a known CLDN14 association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Beyond established FHHNC genes, multiple CLDN family members harbor variants potentially influencing kidney stone risk, possibly through altered paracellular transport and mineral homeostasis. These findings expand kidney stone genetic architecture and suggest that claudin proteins merit further investigation in its pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfag237","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:47:28Z","timestamp":1784116048000},"source":"Crossref","is-referenced-by-count":1,"title":["Novel associations of Claudin gene variants with kidney stone disease"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9444-6602","authenticated-orcid":false,"given":"Iris Y","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Human Genetics, McGill University , Montr\u00e9al, QC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-7797","authenticated-orcid":false,"given":"Jenna","family":"Haverfield","sequence":"additional","affiliation":[{"name":"Research Institute of the 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,","place":["Canada"]},{"name":"Research Institute of the McGill University Health Centre , Montr\u00e9al, QC ,","place":["Canada"]},{"name":"Department of Pediatrics, McGill University , Montr\u00e9al, QC ,","place":["Canada"]},{"name":"Division of Clinical and Translational Medicine, Department of Medicine, McGill University , Montr\u00e9al, QC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-4790","authenticated-orcid":false,"given":"James C","family":"Engert","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University , Montr\u00e9al, QC ,","place":["Canada"]},{"name":"Research Institute of the McGill University Health Centre , Montr\u00e9al, QC ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2460-746X","authenticated-orcid":false,"given":"Indra 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