{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:14:38Z","timestamp":1788243278779,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Magnesium is a potentially relevant factor in kidney stone disease (KSD), particularly in calcium-containing stones. This narrative review summarizes magnesium metabolism, its anti-lithogenic mechanisms, and the current evidence on supplementation in KSD. Magnesium may reduce stone risk through intestinal oxalate binding, inhibition of calcium oxalate crystallization, and increased urinary citrate excretion. A systematic search of PubMed, Web of Science, and Embase (up to April 2026) identified interventional and observational studies evaluating magnesium and urinary or clinical outcomes. Study quality was assessed using the GRADE framework, and the review followed SANRA guidance. Fifteen studies were included, comprising metabolic studies, observational analyses, and four randomized controlled trials. Observational studies consistently report an inverse association between urinary magnesium and stone risk. Interventional studies show improvements in urinary parameters, including increased magnesium and citrate excretion and reduced oxalate, particularly when taken with meals. However, randomized evidence remains limited and heterogeneous. Current evidence does not support routine magnesium supplementation over established therapies such as potassium citrate. Nevertheless, magnesium, especially citrate-containing formulations, may be considered in selected patients, including those with hypomagnesuria, hypocitraturia, or intolerance to potassium salts. Larger, high-quality randomized trials are needed.<\/jats:p>","DOI":"10.1093\/ckj\/sfag248","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:38:39Z","timestamp":1785843519000},"source":"Crossref","is-referenced-by-count":0,"title":["Magnesium and kidney stones: a concise narrative review"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-3524","authenticated-orcid":false,"given":"Martin","family":"Scoglio","sequence":"first","affiliation":[{"name":"Department of Nephrology, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]},{"name":"Graduate School for Health Sciences, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bargagli","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-1803","authenticated-orcid":false,"given":"Daniel G","family":"Fuster","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026090101315965800_bib1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1056\/NEJMra1313341","article-title":"An integrated view of potassium homeostasis","volume":"373","author":"Gumz","year":"2015","journal-title":"N Engl J Med"},{"key":"2026090101315965800_bib2","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1056\/NEJMra1510603","article-title":"Magnesium disorders","volume":"390","author":"Touyz","year":"2024","journal-title":"N Engl J Med"},{"key":"2026090101315965800_bib3","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00018-022-04442-8","article-title":"Structural and functional comparison of magnesium transporters throughout evolution","volume":"79","author":"Franken","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"2026090101315965800_bib4","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.urology.2012.06.033","article-title":"High dietary magnesium intake decreases hyperoxaluria in patients with nephrolithiasis","volume":"80","author":"Eisner","year":"2012","journal-title":"Urology"},{"key":"2026090101315965800_bib5","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1089\/end.2013.0173","article-title":"Effect of magnesium on calcium and oxalate ion binding","volume":"27","author":"Riley","year":"2013","journal-title":"J Endourol"},{"key":"2026090101315965800_bib6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"2026090101315965800_bib7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA-a scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res Integr Peer Rev"},{"key":"2026090101315965800_bib8","first-page":"4186","article-title":"Scientific opinion on dietary reference values for magnesium. 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