{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:39:03Z","timestamp":1792269543138,"version":"4.4.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The use of recombinant human granulocyte-colony stimulating factor (G-CSF) is an uncommon aetiology for acute kidney injury in cancer patients. Several patterns of renal injury due to G-CSF have been discussed in the literature. Here, we present a case of a 48-year-old man with monoclonal gammopathy of renal significance who received filgrastim for planned autologous stem cell transplantation and developed acute kidney injury presenting as crescentic glomerulonephritis. The patient was treated with steroids, plasmapheresis, and cyclophosphamide. He attained complete recovery and proceeded with stem cell transplantation. We conducted an extensive review of the literature on the subject, which revealed that 10 of the 18 biopsy-proven cases of G-CSF-induced renal injury presented as crescentic glomerulonephritis. When G-CSF is administered to patients with an underlying renal pathology (usually autoimmune or monoclonal in aetiology), the migration and degranulation of activated neutrophils in the glomerular microenvironment in large numbers results in glomerular basement membrane rupture and crescent formation. Timely renal biopsy and aggressive initiation of treatment aid in attaining renal recovery and a favourable prognosis in cancer patients.<\/jats:p>","DOI":"10.1093\/ckj\/sfag258","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:25:57Z","timestamp":1786361157000},"source":"Crossref","is-referenced-by-count":1,"title":["Crescentic transformation induced by granulocyte-colony stimulating factor administration\u2014a case report and review of the literature"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-9949","authenticated-orcid":false,"given":"Hariharan","family":"Seshadri","sequence":"first","affiliation":[{"name":"Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center , Houston ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassmin","family":"Falahat","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center , Houston ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"Abdelrahim","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center , Houston ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Geng","sequence":"additional","affiliation":[{"name":"Research Medical Library, The University of Texas MD Anderson Cancer , Houston ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Tchakarov","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center McGovern Medical School Department of Pathology and Laboratory Medicine, , Houston ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-6299","authenticated-orcid":false,"given":"Ala","family":"Abudayyeh","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center , Houston ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026090711171465000_bib1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ajh.10255","article-title":"Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry","volume":"72","author":"Dale","year":"2003","journal-title":"Am J Hematol"},{"key":"2026090711171465000_bib2","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1681\/ASN.2016010061","article-title":"Filgrastim-induced crescentic 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