{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:55:48Z","timestamp":1792418148073,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is associated with increased cardiovascular risk, related to persistent inflammation and endothelial dysfunction. Long-term systolic blood pressure variability (SBPV), reflecting vascular damage, may predict outcomes better than mean blood pressure (BP). We investigated the impact of BP control and visit-to-visit BP variability (VVV), on all-cause mortality in AAV patients during maintenance therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied 95 AAV patients followed at three Italian nephrology centers. SBPV was defined as the standard deviation of \u22654 systolic BP measurements within 12 months from the first SBPV assessment. Patients were stratified by SBPV tertiles. The primary outcome was all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow-up of 78 months, 14 patients (14.7%) died. Deceased patients were older and had higher pulse pressure (PP) and VVV. Hypertension prevalence increased across SBPV tertiles (35%, 62%, 69%; P\u00a0=\u00a0.02). Mortality rose from 6% in the lowest to 34.5% in the highest SBPV tertile (Fisher\u2019s exact, P\u00a0=\u00a0.001). Time-averaged systolic BP was not associated with mortality. Conversely, each 5-mmHg increase in SBPV was associated with a two-fold higher risk of death [hazard ratio (HR) 2.03, 95% confidence interval (CI) 1.29\u20133.20; P\u00a0=\u00a0.002]. SBPV remained significantly associated with outcome after full multi-variable adjustment, including age, sex, myeloperoxidase positivity, estimated glomerular filtration rate, PP, and proteinuria (adjusted HR 8.06 per 1 mmHg, 95% CI 1.42\u201345.54; P\u00a0=\u00a0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In AAV patients, increased VVV was associated with all-cause mortality outperforming mean systolic BP. Further research is needed to confirm the impact of variable blood pressure on patient outcomes in AAV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfag356","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:51:49Z","timestamp":1791373909000},"source":"Crossref","is-referenced-by-count":0,"title":["Blood pressure variability associates with mortality risk of patients with ANCA-associated vasculitis"],"prefix":"10.1093","volume":"19","author":[{"given":"Elisabetta","family":"Bussalino","sequence":"first","affiliation":[{"name":"Nephrology, dialysis and Transplantation Unit, IRCCS Azienda Ospedaliera Metropolitana , Genova ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1279-3178","authenticated-orcid":false,"given":"Elisa","family":"Russo","sequence":"additional","affiliation":[{"name":"Nephrology, dialysis and Transplantation Unit, IRCCS Azienda Ospedaliera 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Brescia\u2013ASST Spedali Civili di Brescia , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Calatroni","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Division, IRCCS Humanitas Research Hospital , Milano ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele , Milano ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4375-4942","authenticated-orcid":false,"given":"Martina","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Universit\u00e0 degli Studi di Brescia\u2013ASST Spedali Civili di Brescia , Brescia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Moroni","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Division, IRCCS Humanitas Research Hospital , Milano 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