{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:27:45Z","timestamp":1781195265711,"version":"3.54.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Kidney Donor Risk Index (KDRI)\/Kidney Donor Profile Index (KDPI) is relied upon for donor organ allocation in the USA, based on its association with graft failure in time-to-event models. However, the KDRI\/KDPI has not been extensively evaluated in terms of predictive metrics for graft failure and allograft estimated glomerular filtration rate (eGFR) outside of the USA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective analysis of outcomes in the Irish National Kidney Transplant Service Registry for the years 2006\u201313. Associations of the KDRI\/KDPI score with eGFR at various time points over the follow-up and ultimate graft failure were modelled.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 772 patients had complete data regarding KDRI\/KDPI calculation and 148 of these allografts failed over the follow-up. The median and 25\u201375th centile for KDRI\/KDPI was 51 (26\u201375). On repeated-measures analysis with linear mixed effects models, the KDRI\/KDPI (fixed effect covariate) associated with eGFR over 5\u2009years: eGFR = \u22120.25 (standard error 0.02; P\u2009&lt;\u20090.001). The variability in eGFR mathematically accounted for by the KDRI\/KDPI score was only 21%. The KDRI\/KDPI score did not add significantly to graft failure prediction above donor age alone (categorized as &gt; and &lt;50\u2009years of age) when assessed by the categorical net reclassification index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this cohort, while the KDRI\/KDPI was predictive of eGFR over the follow-up, it did not provide additive discrimination above donor age alone in terms of graft failure prediction. Therefore it is unlikely to help inform decisions regarding kidney organ allocation in Ireland.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfy130","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T12:09:28Z","timestamp":1544270968000},"page":"569-573","source":"Crossref","is-referenced-by-count":16,"title":["Assessing the discrimination of the Kidney Donor Risk Index\/Kidney Donor Profile Index scores for allograft failure and estimated glomerular filtration rate in Ireland\u2019s National Kidney Transplant Programme"],"prefix":"10.1093","volume":"12","author":[{"given":"Donal J","family":"Sexton","sequence":"first","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"O\u2019Kelly","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Denton","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan G","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conall M","family":"O\u2019Seaghdha","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Conlon","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation, National Kidney Transplant Service, Beaumont Hospital, Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"2019080108303670500_sfy130-B1","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/ndt\/gfx257","article-title":"Does Kidney Donor Risk Index implementation lead to the transplantation of more and higher-quality donor kidneys?","volume":"32","author":"Philipse","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2019080108303670500_sfy130-B2"},{"key":"2019080108303670500_sfy130-B3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/TP.0b013e3181ac620b","article-title":"A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index","volume":"88","author":"Rao","year":"2009","journal-title":"Transplantation"},{"key":"2019080108303670500_sfy130-B4","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1111\/ajt.14379","article-title":"New insights into the alleged kidney donor profile index labeling effect on kidney utilization","volume":"17","author":"Stewart","year":"2017","journal-title":"Am J Transplant"},{"key":"2019080108303670500_sfy130-B5","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1097\/TP.0000000000001824","article-title":"Accept or decline? An analytics-based decision tool for kidney offer evaluation","volume":"101","author":"Bertsimas","year":"2017","journal-title":"Transplantation"},{"key":"2019080108303670500_sfy130-B6","article-title":"Validation of the Living Kidney Donor Profile Index in a European cohort and comparison of long-term outcomes with US results","author":"Rehse","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"2019080108303670500_sfy130-B7","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/ajt.13783","article-title":"Effects of high-risk kidneys on scientific registry of transplant recipients program quality reports","volume":"16","author":"Snyder","year":"2016","journal-title":"Am J Transplant"},{"key":"2019080108303670500_sfy130-B8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/ajt.14462","article-title":"The kidney allocation system does not appropriately stratify risk of pediatric donor kidneys: implications for pediatric 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\u226580","volume":"101","author":"Doshi","year":"2017","journal-title":"Transplantation"},{"key":"2019080108303670500_sfy130-B15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/0886022X.2017.1363778","article-title":"Pre-transplant histology does not improve prediction of 5-year kidney allograft outcomes above and beyond clinical parameters","volume":"39","author":"Traynor","year":"2017","journal-title":"Ren Fail"},{"key":"2019080108303670500_sfy130-B16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/TP.0000000000001889","article-title":"Validation of the prognostic Kidney Donor Risk Index (KDRI) scoring system of deceased donors for renal transplantation in the Netherlands","volume":"102","author":"Peters-Sengers","year":"2018","journal-title":"Transplantation"},{"key":"2019080108303670500_sfy130-B17","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1097\/TP.0000000000001028","article-title":"Kidney Donor Profile Index does not accurately 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