{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:42:34Z","timestamp":1768563754681,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tubular dysfunction can precede serum creatinine increase and reveal renal toxicity.<\/jats:p>","DOI":"10.1093\/ckj\/sfz051","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T07:14:19Z","timestamp":1554880459000},"page":"42-45","source":"Crossref","is-referenced-by-count":26,"title":["A new expression of immune checkpoint inhibitors\u2019 renal toxicity: when distal tubular acidosis precedes creatinine elevation"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-5873","authenticated-orcid":false,"given":"Xavier","family":"Charmetant","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Teuma","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite, France"},{"name":"Immunology Cancer Research (ImmuCare), Institut de Canc\u00e9rologie des Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lake","sequence":"first","affiliation":[{"name":"Institute of Physiology, University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Dijoud","sequence":"first","affiliation":[{"name":"Department of Pathology, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Frochot","sequence":"first","affiliation":[{"name":"Department of Physiology, H\u00f4pital Tenon, APHP, Paris Cedex 20, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Deeb","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"2020021705394452400_sfz051-B1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000455014","article-title":"Adverse renal effects of immune checkpoint inhibitors: a narrative review","volume":"45","author":"Wanchoo","year":"2017","journal-title":"Am J Nephrol"},{"key":"2020021705394452400_sfz051-B2","first-page":"8408015","article-title":"Renal tubular acidosis an adverse effect of PD-1 inhibitor immunotherapy","volume":"2018","author":"El Bitar","year":"2018","journal-title":"Case Rep Oncol Med"},{"key":"2020021705394452400_sfz051-B3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ki.2009.112","article-title":"Autoantibodies against intercalated cells in Sj\u00f6gren\u2019s syndrome","volume":"76","author":"Devuyst","year":"2009","journal-title":"Kidney Int"},{"key":"2020021705394452400_sfz051-B4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejca.2017.12.008","article-title":"Safety and efficacy of anti-programmed death 1 antibodies in patients with cancer and pre-existing autoimmune or inflammatory disease","volume":"91","author":"Danlos","year":"2018","journal-title":"Eur J Cancer"},{"key":"2020021705394452400_sfz051-B5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/ki.2010.97","article-title":"Renal tubular PD-L1 (CD274) suppresses alloreactive human T-cell responses","volume":"78","author":"Starke","year":"2010","journal-title":"Kidney Int"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/13\/1\/42\/32500105\/sfz051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/13\/1\/42\/32500105\/sfz051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T05:40:54Z","timestamp":1581918054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/13\/1\/42\/5489323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,5,14]]},"published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfz051","relation":{},"ISSN":["2048-8505","2048-8513"],"issn-type":[{"value":"2048-8505","type":"print"},{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2019,5,14]]}}}