{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:53:28Z","timestamp":1777643608048,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplantation should improve abnormalities that are common during dialysis treatment, like anaemia and mineral and bone disorder. However, its impact is incompletely understood. We therefore aimed to assess changes in clinical indicators after the transition from chronic dialysis to kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used European Renal Association\u2013European Dialysis and Transplant Association Registry data and included adult dialysis patients for whom data on clinical indicators before and after transplantation (2005\u201315) were available. Linear mixed models were used to quantify the effect of transplantation and of time after transplantation for each indicator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 16\u2002312 patients were included. The mean age at transplantation was 50.1 (standard deviation 14.2) years, 62.9% were male and 70.2% were on haemodialysis before transplantation. Total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol and triglycerides increased right after transplantation but decreased thereafter. All other indicators normalized or approached the target range soon after transplantation and these improvements were sustained for the first 4 years of follow-up. In patients with higher estimated glomerular filtration rate (eGFR) levels (30\u201360 and &amp;gt;60\u2009mL\/min\/1.73 m2), the improvement of haemoglobin, ferritin, ionized calcium, phosphate, parathyroid hormone, HDL cholesterol, triglycerides, albumin and C-reactive protein levels was more pronounced than in patients with a lower eGFR (&amp;lt;30\u2009mL\/min\/1.73 m2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Except for total cholesterol, LDL cholesterol and triglycerides, all clinical indicators improved after transplantation. These improvements were related to eGFR. Nevertheless, values remained out of range in a considerable proportion of patients and anaemia and hyperparathyroidism were still common problems. Further research is needed to understand the complex relationship between eGFR and the different clinical indicators.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ckj\/sfz062","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T11:28:37Z","timestamp":1556278117000},"page":"188-198","source":"Crossref","is-referenced-by-count":5,"title":["Changes in clinical indicators related to the transition from dialysis to kidney transplantation\u2014data from the ERA-EDTA Registry"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-794X","authenticated-orcid":false,"given":"Pichaya","family":"Tantiyavarong","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, Thammasat University, Pathum Thani, Thailand"},{"name":"Nephrology Division, Department of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke","family":"Kramer","sequence":"first","affiliation":[{"name":"ERA-EDTA Registry, Amsterdam UMC, Department of Medical Informatics, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G","family":"Heaf","sequence":"first","affiliation":[{"name":"Department of Medicine, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Finne","sequence":"first","affiliation":[{"name":"Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Finnish Registry for Kidney Diseases, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00c5sberg","sequence":"first","affiliation":[{"name":"Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway"},{"name":"School of Pharmacy, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleix","family":"Cases","sequence":"first","affiliation":[{"name":"Nephrology Unit, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain"},{"name":"Registre de Malalts Renals de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergus J","family":"Caskey","sequence":"first","affiliation":[{"name":"UK Renal Registry, Southmead Hospital, Bristol, UK"},{"name":"Population Health Sciences, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad A","family":"Massy","sequence":"first","affiliation":[{"name":"Division of Nephrology, Ambroise Par\u00e9 University Hospital, APHP, Boulogne-Billancourt, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit 1018 team5, Research Centre in Epidemiology and Population Health (CESP), University of Paris Ouest-Versailles-St Quentin-en-Yveline, Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty J","family":"Jager","sequence":"first","affiliation":[{"name":"ERA-EDTA Registry, Amsterdam UMC, Department of Medical Informatics, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Noordzij","sequence":"first","affiliation":[{"name":"ERA-EDTA Registry, Amsterdam UMC, Department of Medical Informatics, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The 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