{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:44:39Z","timestamp":1780580679867,"version":"3.54.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fresenius Medical Care Deutschland GmbH","award":["NL33129.068.10"],"award-info":[{"award-number":["NL33129.068.10"]}]},{"name":"Fresenius Medical Care Deutschland GmbH","award":["NL43381.068.13"],"award-info":[{"award-number":["NL43381.068.13"]}]},{"DOI":"10.13039\/100004702","name":"Baxter","doi-asserted-by":"publisher","award":["NL35039.068.10"],"award-info":[{"award-number":["NL35039.068.10"]}],"id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","award":["NL35039.068.10"],"award-info":[{"award-number":["NL35039.068.10"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>End-stage renal disease (ESRD) is strongly associated with cardiovascular disease (CVD) risk. Advanced glycation endproducts (AGEs) and dicarbonyls, major precursors of AGEs, may contribute to the pathophysiology of CVD in ESRD. However, detailed data on the courses of AGEs and dicarbonyls during the transition of ESRD patients to renal replacement therapy are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We quantified an extensive panel of free and protein-bound serum AGEs [N\u2208-(carboxymethyl)lysine (CML), N\u2208-(carboxyethyl)lysine (CEL), N\u03b4-(5-hydro-5-methyl-4-imidazolon-2-yl)ornithine (MG-H1)], serum dicarbonyls [glyoxal (GO), methylglyoxal (MGO), 3-deoxyglucosone (3-DG)] and tissue AGE accumulation [estimated by skin autofluorescence (SAF)] in a combined cross-sectional and longitudinal observational study of patients with ESRD transitioning to dialysis or kidney transplantation (KTx), prevalent dialysis patients and healthy controls. Cross-sectional comparisons were performed with linear regression analyses, and courses following renal replacement therapy were analysed with linear mixed models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Free and protein-bound AGEs, dicarbonyls and SAF were higher in chronic kidney disease (CKD) Stage 5 non-dialysis (CKD 5-ND; n = 52) and CKD Stage 5 dialysis (CKD 5-D; n = 35) than in controls (n\u2009=\u200942). In addition, free AGEs, protein-bound CML, GO and SAF were even higher in CKD 5-D than in CKD5-ND. Similarly, following dialysis initiation (n\u2009=\u200943) free and protein-bound AGEs, and GO increased, whereas SAF remained similar. In contrast, following KTx (n\u2009=\u200921), free and protein-bound AGEs and dicarbonyls, but not SAF, markedly declined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AGEs and dicarbonyls accumulate in uraemia, which is even exaggerated by dialysis initiation. In contrast, KTx markedly reduces AGEs and dicarbonyls. Given their associations with CVD risk in high-risk populations, lowering AGE and dicarbonyl levels may be valuable.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfz099","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T19:18:11Z","timestamp":1563391091000},"page":"855-866","source":"Crossref","is-referenced-by-count":11,"title":["Advanced glycation endproducts and dicarbonyls in end-stage renal disease: associations with uraemia and courses following renal replacement therapy"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-6412","authenticated-orcid":false,"given":"Remy J H","family":"Martens","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, Maastricht, The Netherlands"},{"name":"CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha J H","family":"Broers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, Maastricht, The Netherlands"},{"name":"NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Canaud","sequence":"additional","affiliation":[{"name":"Medical Office EMEA, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany"},{"name":"School of Medicine, Montpellier University, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten H L","family":"Christiaans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Cornelis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jessa Hospital, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Gauly","sequence":"additional","affiliation":[{"name":"Medical Office EMEA, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc M H","family":"Hermans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Viecuri Medical Center, Venlo, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantijn J A M","family":"Konings","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Catharina Hospital Eindhoven, Eindhoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M","family":"van der Sande","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean L J M","family":"Scheijen","sequence":"additional","affiliation":[{"name":"CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands"},{"name":"Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Stifft","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Zuyderland Medical Center, Sittard-Geleen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen 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