{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:22:01Z","timestamp":1792794121925,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["2746-15-8"],"award-info":[{"award-number":["2746-15-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brazilian National Research Council","award":["481649\/2013-1"],"award-info":[{"award-number":["481649\/2013-1"]}]},{"name":"Brazilian National Research Council","award":["301037\/2016-7"],"award-info":[{"award-number":["301037\/2016-7"]}]},{"name":"Brazilian National Research Council","award":["430246\/2018-8"],"award-info":[{"award-number":["430246\/2018-8"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais grants","award":["PPM-00228-15"],"award-info":[{"award-number":["PPM-00228-15"]}],"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais grants","award":["PPM-00555-1"],"award-info":[{"award-number":["PPM-00555-1"]}],"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais grants","award":["PPM-00435-18"],"award-info":[{"award-number":["PPM-00435-18"]}],"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais grants","award":["APQ-02541-17"],"award-info":[{"award-number":["APQ-02541-17"]}],"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antenatal hydronephrosis (ANH) affects \u223c1\u20135% of pregnancies. The aim of this study was to develop a clinical prediction model of renal injury in a large cohort of infants with isolated ANH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a longitudinal cohort study of 447 infants with ANH admitted since birth between 1989 and 2015 at a tertiary care center. The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension and chronic kidney disease (CKD). A predictive model was developed using a Cox proportional hazards model and evaluated by C-statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Renal pelvic dilatation (RPD) was classified into two groups [Grades 1\u20132 (n\u2009=\u2009255) versus Grades 3\u20134 (n\u2009=\u2009192)]. The median follow-up time was 6.4\u2009years (interquartile range 2.8\u201312.5). Thirteen patients (2.9%) developed proteinuria, 6 (1.3%) hypertension and 14 (3.1%) CKD Stage 2. All events occurred in patients with RPD Grades 3\u20134. After adjustment, three covariables remained as predictors of the composite event: creatinine {hazard ratio [HR] 1.27, [95% confidence interval (CI) 1.05\u20131.56]}, renal parenchyma thickness at birth [HR 0.78(95% CI 0.625\u20130.991)] and recurrent urinary tract infections [HR 4.52 (95% CI 1.49\u201313.6)]. The probability of renal injury at 15\u2009years of age was estimated as 0, 15 and 24% for patients assigned to the low-risk, medium-risk and high-risk groups, respectively (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate an uneventful clinical course for patients with Society for Fetal Urology (SFU) Grades 1\u20132 ANH. Conversely, for infants with SFU Grades 3\u20134 ANH, our prediction model enabled the identification of a subgroup of patients with increased risk of renal injury over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ckj\/sfz102","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T15:18:11Z","timestamp":1563376691000},"page":"834-841","source":"Crossref","is-referenced-by-count":12,"title":["A clinical predictive model of renal injury in children with isolated antenatal hydronephrosis"],"prefix":"10.1093","volume":"13","author":[{"given":"Fernanda P","family":"Costa","sequence":"first","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3882","authenticated-orcid":false,"given":"Ana C","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H","family":"Mak","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology, Rady Children\u2019s Hospital San Diego, University of California, San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, University of California, San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana A","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane S","family":"Dias","sequence":"additional","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina C","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Christina L","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-7164","authenticated-orcid":false,"given":"Eduardo A","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Pediatric Nephrourology Division, Department of Pediatrics, National Institute of Science and Technology of Molecular Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil"},{"name":"Division of Pediatric Nephrology, Rady Children\u2019s Hospital San Diego, University of California, San Diego, San Diego, CA, 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