{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:27:24Z","timestamp":1778797644500,"version":"3.51.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FIS\/FEDER","award":["CP16\/00017"],"award-info":[{"award-number":["CP16\/00017"]}]},{"name":"FIS\/FEDER","award":["PI16\/02057"],"award-info":[{"award-number":["PI16\/02057"]}]},{"name":"FIS\/FEDER","award":["PI17\/00130"],"award-info":[{"award-number":["PI17\/00130"]}]},{"name":"FIS\/FEDER","award":["PI17\/01495"],"award-info":[{"award-number":["PI17\/01495"]}]},{"name":"ISCIII-RETIC Red de Investigacion Renal","award":["RD016\/0009"],"award-info":[{"award-number":["RD016\/0009"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["RYC-2017-22369"],"award-info":[{"award-number":["RYC-2017-22369"]}]},{"DOI":"10.13039\/501100008963","name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundacion Renal I\u00f1igo \u00c1lvarez de Toledo and Comunidad de Madrid","award":["CIFRA2 B2017\/BMD-3686"],"award-info":[{"award-number":["CIFRA2 B2017\/BMD-3686"]}]},{"name":"FIS\/FEDER","award":["FI18\/00310"],"award-info":[{"award-number":["FI18\/00310"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.<\/jats:p>","DOI":"10.1093\/ckj\/sfz104","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T19:10:45Z","timestamp":1562872245000},"page":"424-428","source":"Crossref","is-referenced-by-count":12,"title":["Podocyte and tubular involvement in AngioJet-induced kidney injury"],"prefix":"10.1093","volume":"14","author":[{"given":"Raquel","family":"Esteras","sequence":"first","affiliation":[{"name":"Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute (IIS-FJD), Autonoma University of Madrid, Madrid, Spain"},{"name":"Red de Investigacion Renal, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Cannata-Ortiz","sequence":"additional","affiliation":[{"name":"Red de Investigacion Renal, Madrid, Spain"},{"name":"Department of Pathology, Fundacion Jimenez Diaz University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta del","family":"Palacio-Tamarit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fundacion Jimenez Diaz University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melania","family":"Guerrero-Hue","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory, Fundacion Jimenez Diaz Health Research Institute, Autonoma University of Madrid, Madrid, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Maimonides Biomedical Research Institute of Cordoba, University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garc\u00eda-Caballero","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory, Fundacion Jimenez Diaz Health Research Institute, Autonoma University of Madrid, Madrid, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Maimonides Biomedical Research Institute of Cordoba, University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute (IIS-FJD), Autonoma University of Madrid, Madrid, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fundacion Jimenez Diaz Health Research Institute 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"2021020321164107500_sfz104-B1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.jvs.2016.09.047","article-title":"Increased risk of renal dysfunction with percutaneous mechanical thrombectomy compared with catheter-directed thrombolysis","volume":"65","author":"Morrow","year":"2017","journal-title":"J Vasc Surg"},{"key":"2021020321164107500_sfz104-B2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/ncpneph1019","article-title":"Acute kidney injury caused by intravascular hemolysis after mechanical thrombectomy","volume":"5","author":"Dukkipati","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"2021020321164107500_sfz104-B3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.avsg.2016.12.018","article-title":"Risk of acute kidney injury after percutaneous pharmacomechanical thrombectomy 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