{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:02:31Z","timestamp":1789779751609,"version":"4.0.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this issue of Clinical Kidney Journal, Gamayo et al. describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of the present report consists of the association of a disease thought to be rare (only 13 in prior described patients, 11 in the past year) with B-cell lymphoproliferative disease. Together with the finding of a third case among 224 elderly patients studied, this raises the issue of the underdiagnoses of LRP2 nephropathy, on top of the potential association to B-cell malignancy. We now put these findings in context within the wider frame of autoimmunity against megalin\/LRP2 and related antigens such as Fx1A and CD69.<\/jats:p>","DOI":"10.1093\/ckj\/sfz171","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T20:09:21Z","timestamp":1577995761000},"source":"Crossref","is-referenced-by-count":6,"title":["Megalin\/lipoprotein receptor-related protein 2 autoimmunity and kidney disease"],"prefix":"10.1093","author":[{"given":"Maria V","family":"Perez-Gomez","sequence":"first","affiliation":[{"name":"IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain"},{"name":"Fundacion Renal I\u00f1igo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D","family":"Sanchez-Ni\u00f1o","sequence":"first","affiliation":[{"name":"IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain"},{"name":"Fundacion Renal I\u00f1igo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ortiz","sequence":"first","affiliation":[{"name":"IIS-Fundacion Jimenez Diaz, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain"},{"name":"Fundacion Renal I\u00f1igo Alvarez de Toledo-IRSIN and REDINREN, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"2020031909575153500_sfz171-B1","article-title":"Anti-LRP2 nephropathy with concurrent kidney infiltration by lymphoma: report of 2 cases","author":"Gamayo","journal-title":"Clin Kidney J"},{"key":"2020031909575153500_sfz171-B2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1681\/ASN.2017060664","article-title":"LDL receptor-related protein 2 (Megalin) as a target antigen in human kidney anti-brush border antibody disease","volume":"29","author":"Larsen","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"2020031909575153500_sfz171-B3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1053\/j.ajkd.2018.12.039","article-title":"Anti-LRP2 nephropathy with abundant IgG4-positive plasma cells: a case report","volume":"74","author":"Dinesh","year":"2019","journal-title":"Am J Kidney Dis"},{"key":"2020031909575153500_sfz171-B4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.kint.2015.11.007","article-title":"Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease","volume":"89","author":"Nielsen","year":"2016","journal-title":"Kidney Int"},{"key":"2020031909575153500_sfz171-B5","doi-asserted-by":"crossref","first-page":"e25065","DOI":"10.1371\/journal.pone.0025065","article-title":"Receptor-mediated endocytosis of \u03b1-galactosidase A in human podocytes in Fabry disease","volume":"6","author":"Prabakaran","year":"2011","journal-title":"PLoS One"},{"key":"2020031909575153500_sfz171-B6","doi-asserted-by":"crossref","first-page":"13705","DOI":"10.1038\/s41598-017-13789-z","article-title":"Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex","volume":"7","author":"Gianesello","year":"2017","journal-title":"Sci Rep"},{"key":"2020031909575153500_sfz171-B7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1681\/ASN.2015040405","article-title":"Necroinflammation in kidney disease","volume":"27","author":"Mulay","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2020031909575153500_sfz171-B8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/ndt\/gfs462","article-title":"Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration","volume":"28","author":"Storm","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2020031909575153500_sfz171-B9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1681\/ASN.V124667","article-title":"The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes","volume":"12","author":"Patrie","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"2020031909575153500_sfz171-B10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/oxfordjournals.ndt.a092131","article-title":"Presence of circulating antibodies against brush border antigens (Fx1A) in a patient with membranous nephropathy and bilateral pyeloureteral stenosis. 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