{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:31:53Z","timestamp":1773736313993,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Polycystic Kidney Diseases Foundation"},{"name":"ICES Kidney"},{"name":"Dialysis and Transplantation Program"},{"name":"Canadian Institutes of Health Research Doctoral Scholarship"},{"name":"Kidney Research Scientist Core Education and National Training Program"},{"DOI":"10.13039\/501100000191","name":"Kidney Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The ability to identify patients with autosomal dominant polycystic kidney disease (ADPKD) and distinguish them from patients with similar conditions in healthcare administrative databases is uncertain. We aimed to measure the sensitivity and specificity of different ADPKD administrative coding algorithms in a clinic population with non-ADPKD and ADPKD kidney cystic disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used a dataset of all patients who attended a hereditary kidney disease clinic in Toronto, Ontario, Canada between 1 January 2010 and 23 December 2014. This dataset included patients who met our reference standard definition of ADPKD or other cystic kidney disease. We linked this dataset to healthcare databases in Ontario. We developed eight algorithms to identify ADPKD using the International Classification of Diseases, 10th Revision (ICD-10) codes and provincial diagnostic billing codes. A patient was considered algorithm positive if any one of the codes in the algorithm appeared at least once between 1 April 2002 and 31 March 2015.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The ICD-10 coding algorithm had a sensitivity of 33.7% [95% confidence interval (CI) 30.0\u201337.7] and a specificity of 86.2% (95% CI 75.7\u201392.5) for the identification of ADPKD. The provincial diagnostic billing code had a sensitivity of 91.1% (95% CI 88.5\u201393.1) and a specificity of 10.8% (95% CI 5.3\u201320.6).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ICD-10 coding may be useful to identify patients with a high chance of having ADPKD but fail to identify many patients with ADPKD. Provincial diagnosis billing codes identified most patients with ADPKD and also with other types of cystic kidney disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ckj\/sfz184","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T20:11:03Z","timestamp":1575058263000},"page":"612-616","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic accuracy of administrative codes for autosomal dominant polycystic kidney disease in clinic patients with cystic kidney disease"],"prefix":"10.1093","volume":"14","author":[{"given":"Vinusha","family":"Kalatharan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"McArthur","sequence":"additional","affiliation":[{"name":"ICES, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle M","family":"Nash","sequence":"additional","affiliation":[{"name":"ICES, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blayne","family":"Welk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada"},{"name":"ICES, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisira","family":"Sarma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada"},{"name":"ICES, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit X","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada"},{"name":"ICES, London, Ontario, Canada"},{"name":"Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"York","family":"Pei","sequence":"additional","affiliation":[{"name":"University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"2021021623483624400_sfz184-B1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu Rev Med"},{"key":"2021021623483624400_sfz184-B2","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1681\/ASN.2010101080","article-title":"Mutations in multiple PKD genes may explain early and severe polycystic kidney disease","volume":"22","author":"Bergmann","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2021021623483624400_sfz184-B3","doi-asserted-by":"crossref","first-page":"2054358116679130","DOI":"10.1177\/2054358116679130","article-title":"Positive predictive values of International Classification of Diseases, 10th Revision coding algorithms to identify patients with autosomal dominant polycystic kidney disease","volume":"3","author":"Kalatharan","year":"2016","journal-title":"Can J Kidney Health Dis"},{"key":"2021021623483624400_sfz184-B4","doi-asserted-by":"crossref","first-page":"212275","DOI":"10.7573\/dic.212275","article-title":"Progression of autosomal dominant kidney disease: measurement of the stage transitions of chronic kidney disease","volume":"4","author":"Blanchette","year":"2015","journal-title":"Drugs Context"},{"key":"2021021623483624400_sfz184-B5","doi-asserted-by":"crossref","first-page":"W1","DOI":"10.7326\/0003-4819-138-1-200301070-00012-w1","article-title":"The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration","volume":"138","author":"Bossuyt","year":"2003","journal-title":"Ann Intern Med"},{"key":"2021021623483624400_sfz184-B6","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(94)90137-6","article-title":"European Polycystic Kidney Disease Consortium. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16","volume":"77","year":"1994","journal-title":"Cell"},{"key":"2021021623483624400_sfz184-B7","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","article-title":"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein","volume":"272","author":"Mochizuki","year":"1996","journal-title":"Science"},{"key":"2021021623483624400_sfz184-B8","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1681\/ASN.2015060648","article-title":"Refining genotype\u2013phenotype correlation in autosomal dominant polycystic kidney disease","volume":"27","author":"Hwang","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2021021623483624400_sfz184-B9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1681\/ASN.2008050507","article-title":"Unified criteria for ultrasonographic diagnosis of ADPKD","volume":"20","author":"Pei","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2021021623483624400_sfz184-B10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E","article-title":"Two-sided confidence intervals for the single proportion: comparison of seven methods","volume":"17","author":"Newcombe","year":"1998","journal-title":"Stat Med"},{"key":"2021021623483624400_sfz184-B11","author":"Weiner","year":"2011"},{"key":"2021021623483624400_sfz184-B12","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1464-5491.2011.03568.x","article-title":"Using the Johns Hopkins\u2019 aggregated diagnosis groups (ADGs) to predict 1-year mortality in population-based cohorts of patients with diabetes in Ontario, Canada","volume":"29","author":"Austin","year":"2012","journal-title":"Diabetics Med"},{"key":"2021021623483624400_sfz184-B13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2147\/CEOR.S75523","article-title":"Medical resource utilization and costs associated with autosomal dominant polycystic kidney disease in the USA: a retrospective matched cohort analysis of private insurer data","volume":"7","author":"Knight","year":"2015","journal-title":"Clinicoecon Outcomes Res"}],"container-title":["Clinical Kidney Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/2\/612\/36284077\/sfz184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ckj\/article-pdf\/14\/2\/612\/36284077\/sfz184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T12:34:35Z","timestamp":1613738075000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ckj\/article\/14\/2\/612\/5710697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,1,20]]},"published-print":{"date-parts":[[2021,2,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ckj\/sfz184","relation":{},"ISSN":["2048-8513"],"issn-type":[{"value":"2048-8513","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2020,1,20]]}}}