{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:04:43Z","timestamp":1790823883828,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Biomarkers Consortium of the Foundation for the National Institutes of Health and NIH\/NHLBI","award":["K24 HL152440"],"award-info":[{"award-number":["K24 HL152440"]}]},{"name":"Biomarkers Consortium of the Foundation for the National Institutes of Health and NIH\/NHLBI","award":["T32 HL007024"],"award-info":[{"award-number":["T32 HL007024"]}]},{"name":"NIH\/NIDDK","award":["F30 DK120160"],"award-info":[{"award-number":["F30 DK120160"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Glycated albumin is of growing interest as an alternative biomarker of glycemia. However, the association of glycated albumin with long-term outcomes in the general population is uncharacterized. We evaluated the associations of glycated albumin and hemoglobin A1c (HbA1c) with mortality in US adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective analysis of 12\u00a0915 participants in the National Health and Nutrition Examination Survey 1999\u20132004. We used Cox regression to characterize associations of glycated albumin and HbA1c with all-cause and cardiovascular mortality through 2014. We categorized glycated albumin based on percentiles corresponding to clinical cut-points for HbA1c. No diagnosed diabetes: &amp;lt;5.0% (&amp;lt;12th percentile), 5.0% to 5.6% (12th\u201382nd percentile, reference), 5.7% to 6.4% (83rd\u201397th percentile), and \u22656.5% (\u226598th percentile). Diagnosed diabetes: &amp;lt;7.0% (&amp;lt;50th percentile), 7.0% to 8.9% (50th\u201383rd percentile), and \u22659.0% (\u226584th percentile).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among US adults (mean age 46\u2009years), the prevalence of diagnosed diabetes was 6.8%. Glycated albumin and HbA1c were highly correlated (r\u2009=\u20090.76). Over the median 16.8\u2009years follow-up, there were 2818 deaths (652 cardiovascular). Adults with diagnosed diabetes and glycated albumin \u226584th percentile had the highest risk for all-cause mortality [hazard ratio (HR) 3.96, 95% CI 3.06\u20135.13] and cardiovascular mortality (HR 6.80, 95% CI 4.20\u201311.03). HbA1c had associations with all-cause and cardiovascular mortality that were similar to those for glycated albumin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among US adults, increased values of glycated albumin and HbA1c were associated with all-cause and cardiovascular mortality, particularly in persons with diagnosed diabetes. Glycated albumin may be a useful alternative test of glycemia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/clinchem\/hvab232","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T19:23:51Z","timestamp":1633548231000},"page":"422-430","source":"Crossref","is-referenced-by-count":32,"title":["Glycated Albumin and Risk of Mortality in the US Adult Population"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-4848","authenticated-orcid":false,"given":"Mary R","family":"Rooney","sequence":"first","affiliation":[{"name":"Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 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