{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:49:04Z","timestamp":1793256544055,"version":"4.5.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D, acknowledged since the 1930s for its role in preventing rickets, gained additional prominence in relation to fragility fracture prevention in the late 1980s. From the early 2000s, connections between vitamin D deficiency and extra-skeletal pathologies emerged, alongside increased awareness of widespread deficits. This prompted crucial debates on optimal serum concentrations, expected to conclude when the outcomes of high-dose supplementation randomized controlled trials were available. Skepticism arose with inconclusive results from these trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>This review begins with an exploration of vitamin D metabolism, followed by a detailed description of the measurement of vitamin D metabolites and the crucial role of standardization. Subsequent sections focus on the association of vitamin D with bone health and explore the extra-skeletal effects. The review concludes with a comprehensive discussion on the definition of vitamin D status and its implications for supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Despite standardization efforts, assay variations and challenges still exist, especially in specific patient groups. Vitamin D supplementation has a significant impact on bone metabolism and optimal vitamin D status improves the efficacy of antiresorptive drugs such as bisphosphonates. The extra-skeletal effects of vitamin D remain debated, but may include potential benefits in conditions such as respiratory infections and cancer mortality, particularly in deficient individuals. The definition of vitamin D sufficiency is nuanced, especially when variations in population groups and analytical methods are taken into account. Despite ongoing debates and recent mega-trials tempering enthusiasm, vitamin D remains a complex and essential element in human health. Further research is needed to clarify its role in various health outcomes and guide supplementation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/clinchem\/hvae056","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T10:46:17Z","timestamp":1712141177000},"page":"1104-1121","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin D: Analytical Advances, Clinical Impact, and Ongoing Debates on Health Perspectives"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-2226","authenticated-orcid":false,"given":"Etienne","family":"Cavalier","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, University of Li\u00e8ge, CIRM, CHU de Li\u00e8ge , Li\u00e8ge , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-9028","authenticated-orcid":false,"given":"Konstantinos","family":"Makris","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Department, KAT General Hospital , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-9955","authenticated-orcid":false,"given":"Annemieke C","family":"Heijboer","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam Gastroenterology & Metabolism, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam UMC , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-9899","authenticated-orcid":false,"given":"Markus","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Souberbielle","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Exploration Fonctionnelles, H\u00f4pital Necker-Enfants Malades , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"2024090223531231500_hvae056-B1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cca.2021.03.002","article-title":"Recommendations on the measurement and the clinical use of vitamin D metabolites and vitamin D binding protein\u2014a position paper from the IFCC Committee on bone metabolism","volume":"517","author":"Makris","year":"2021","journal-title":"Clin Chim Acta"},{"key":"2024090223531231500_hvae056-B2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2024090223531231500_hvae056-B3","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2024090223531231500_hvae056-B4","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.5740\/jaoacint.17-0259","article-title":"General steps to standardize the laboratory measurement of serum total 25-hydroxyvitamin D","volume":"100","author":"Sempos","year":"2017","journal-title":"J AOAC Int"},{"key":"2024090223531231500_hvae056-B5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol Rev"},{"key":"2024090223531231500_hvae056-B6","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3389\/fendo.2019.00910","article-title":"Vitamin D binding protein: a historic overview","volume":"10","author":"Bouillon","year":"2020","journal-title":"Front Endocrinol"},{"key":"2024090223531231500_hvae056-B7","doi-asserted-by":"crossref","first-page":"109639","DOI":"10.1016\/j.abb.2023.109639","article-title":"Enzymatic activation in vitamin D signaling\u2013past, present and future","volume":"742","author":"Norlin","year":"2023","journal-title":"Arch Biochem Biophys"},{"key":"2024090223531231500_hvae056-B8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1194\/jlr.R031534","article-title":"Cytochrome P450-mediated metabolism of vitamin D","volume":"55","author":"Jones","year":"2014","journal-title":"J Lipid Res"},{"issue":"Suppl 1","key":"2024090223531231500_hvae056-B9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1744-9987.2011.00920.x","article-title":"Role of megalin and cubilin in the metabolism of vitamin D3","volume":"15","author":"Kaseda","year":"2011","journal-title":"Ther Apher Dial"},{"key":"2024090223531231500_hvae056-B10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/jbmr.4876","article-title":"Measurements of the vitamin D metabolome in the calgary vitamin D study: relationship of vitamin D metabolites to bone loss","volume":"38","author":"Burt","year":"2023","journal-title":"J Bone Miner Res"},{"key":"2024090223531231500_hvae056-B11","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1373\/clinchem.2013.206128","article-title":"Influence of vitamin D2 percentage on accuracy of 4 commercial total 25-hydroxyvitamin D assays","volume":"59","author":"Shu","year":"2013","journal-title":"Clin Chem"},{"key":"2024090223531231500_hvae056-B12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jsbmb.2015.12.018","article-title":"25-Hydroxyvitamin D assays: potential interference from other circulating vitamin D metabolites","volume":"164","author":"Carter","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2024090223531231500_hvae056-B13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1515\/CCLM.2011.050","article-title":"Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D3 in serum of infants and adults","volume":"49","author":"Stepman","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"2024090223531231500_hvae056-B14","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.clinbiochem.2017.06.011","article-title":"Standardization of automated 25-hydroxyvitamin D assays: how successful is it?","volume":"50","author":"Elsenberg","year":"2017","journal-title":"Clin Biochem"},{"key":"2024090223531231500_hvae056-B15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cca.2012.10.056","article-title":"Accuracy of three automated 25-hydroxyvitamin D assays in hemodialysis patients","volume":"415","author":"Depreter","year":"2013","journal-title":"Clin Chim Acta"},{"key":"2024090223531231500_hvae056-B16","first-page":"1347","article-title":"Analytical and clinical evaluation of the new Fujirebio Lumipulse\u00aeG non-competitive assay for 25(OH)-vitamin D and three immunoassays for 25(OH)D in healthy subjects, osteoporotic patients, third trimester pregnant women, healthy African subjects","volume":"54","author":"Cavalier","year":"2016","journal-title":"Clin Chem Lab Med"},{"key":"2024090223531231500_hvae056-B17","first-page":"32","article-title":"Vitamin D status as an international issue: national surveys and the problem of standardization","volume":"243","author":"Sempos","year":"2012","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"2024090223531231500_hvae056-B18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/nu13020431","article-title":"Analytical performance specifications for 25-hydroxyvitamin D examinations","volume":"13","author":"Cavalier","year":"2021","journal-title":"Nutrients"},{"key":"2024090223531231500_hvae056-B19","first-page":"1010","article-title":"Evaluation of the 25-hydroxy vitamin D assay on a fully automated liquid chromatography mass spectrometry system, the Thermo Scientific Cascadion SM Clinical Analyzer with the Cascadion 25-hydroxy vitamin D assay in a routine clinical laboratory","volume":"25","author":"Benton","year":"2019","journal-title":"Clin Chem Lab Med"},{"key":"2024090223531231500_hvae056-B20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jsbmb.2017.02.004","article-title":"1\u03b2,25-Dihydroxyvitamin D3: a new vitamin D metabolite in human serum","volume":"173","author":"Pauwels","year":"2017","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2024090223531231500_hvae056-B21","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1021\/acs.analchem.5b01861","article-title":"Candidate reference measurement procedure for the determination of (24 R),25\u2013dihydroxyvitamin D3 in human Serum using isotope-dilution liquid chromatography\u2013tandem mass spectrometry","volume":"87","author":"Tai","year":"2015","journal-title":"Anal Chem"},{"key":"2024090223531231500_hvae056-B22","doi-asserted-by":"crossref","first-page":"e10418","DOI":"10.1002\/jbm4.10418","article-title":"The free hormone hypothesis: when, why, and how to measure the free hormone levels to assess vitamin D, thyroid, sex hormone, and cortisol status","volume":"5","author":"Bikle","year":"2021","journal-title":"JBMR Plus"},{"key":"2024090223531231500_hvae056-B23","first-page":"2584","article-title":"Vitamin D\u2013binding protein deficiency and homozygous deletion of the GC gene","volume":"380","author":"Berg","year":"2019","journal-title":"N Engl J Med"},{"key":"2024090223531231500_hvae056-B24","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1210\/jcem-63-4-954","article-title":"Assessment of the free fraction 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein","volume":"63","author":"Bikle","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2024090223531231500_hvae056-B25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/endo-124-2-649","article-title":"Free, and not total, 1, 25\u2013dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes","volume":"124","author":"Bikle","year":"1989","journal-title":"Endocrinology"},{"key":"2024090223531231500_hvae056-B26","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa1306357","article-title":"Vitamin D-binding protein and vitamin D status of black Americans and white Americans","volume":"369","author":"Powe","year":"2013","journal-title":"N Engl J Med"},{"key":"2024090223531231500_hvae056-B27","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/jbmr.2829","article-title":"Comparison of two ELISA methods and mass spectrometry for measurement of vitamin D-binding protein: implications for the assessment of bioavailable vitamin D concentrations across genotypes","volume":"31","author":"Denburg","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2024090223531231500_hvae056-B28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00223-022-00961-5","article-title":"Vitamin D metabolites: analytical challenges and clinical relevance","volume":"112","author":"Alonso","year":"2022","journal-title":"Calcif Tissue Int"},{"key":"2024090223531231500_hvae056-B29","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.3390\/nu14193894","article-title":"Vitamin D-binding protein, bioavailable, and free 25 (OH) D, and mortality: a systematic review and meta-analysis","volume":"14","author":"Zhu","year":"2022","journal-title":"Nutrients"},{"key":"2024090223531231500_hvae056-B30","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s12603-018-1080-y","article-title":"Screening for vitamin D deficiency in Black Americans: comparison of total, free, bioavailable 25 hydroxy vitamin D levels with parathyroid hormone levels and bone mineral density","volume":"22","author":"McKee","year":"2018","journal-title":"J Nutr Health Aging"},{"key":"2024090223531231500_hvae056-B31","doi-asserted-by":"crossref","first-page":"e990","DOI":"10.1210\/clinem\/dgaa780","article-title":"Total, bioavailable, and free 25(OH)D relationship with indices of bone health in elderly: a randomized controlled trial","volume":"106","author":"El Sabeh","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2024090223531231500_hvae056-B32","doi-asserted-by":"crossref","first-page":"e0258585","DOI":"10.1371\/journal.pone.0258585","article-title":"Total, bioavailable and free 25-hydroxyvitamin D levels as functional indicators for bone parameters in healthy children","volume":"16","author":"Heo","year":"2021","journal-title":"PLoS One"},{"key":"2024090223531231500_hvae056-B33","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00198-017-4062-8","article-title":"Comparison of total, free and bioavailable 25-OH vitamin D determinations to evaluate its biological activity in healthy adults: the LabOscat study","volume":"28","author":"Peris","year":"2017","journal-title":"Osteoporos Int"},{"key":"2024090223531231500_hvae056-B34","doi-asserted-by":"crossref","first-page":"e011021","DOI":"10.1161\/JAHA.118.011021","article-title":"Racial\/ethnic differences in 25-hydroxy vitamin D and parathyroid hormone levels and cardiovascular disease risk among postmenopausal women","volume":"8","author":"Zhang","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2024090223531231500_hvae056-B35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/bonekey.2013.230","article-title":"Vitamin D endocrine system and the intestine","volume":"3","author":"Christakos","year":"2014","journal-title":"Bonekey Rep"},{"key":"2024090223531231500_hvae056-B36","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI45890","article-title":"Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D\u2013induced inhibition of bone mineralization","volume":"122","author":"Lieben","year":"2012","journal-title":"J Clin Invest"},{"key":"2024090223531231500_hvae056-B37","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1172\/JCI29449","article-title":"Resurrection of vitamin D deficiency and rickets","volume":"116","author":"Holick","year":"2006","journal-title":"J Clin Invest"},{"key":"2024090223531231500_hvae056-B38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.ecl.2017.07.011","article-title":"Genetic diseases of vitamin D metabolizing enzymes","volume":"46","author":"Jones","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2024090223531231500_hvae056-B39","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3945\/ajcn.116.134981","article-title":"Hypercalcemia, hypercalciuria, and kidney stones in long-term studies of vitamin D supplementation: a systematic review and meta-analysis","volume":"104","author":"Malihi","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"2024090223531231500_hvae056-B40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40618-016-0553-2","article-title":"How the reference values for serum parathyroid hormone concentration are (or should be) established?","volume":"40","author":"Souberbielle","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"2024090223531231500_hvae056-B41","doi-asserted-by":"crossref","first-page":"E1946","DOI":"10.1210\/jc.2013-3105","article-title":"Determination of reference intervals for serum total calcium in the vitamin D-replete pediatric population","volume":"98","author":"Roizen","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2024090223531231500_hvae056-B42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/j.jrn.2018.05.006","article-title":"Overview of the 2017 KDIGO CKD-MBD update: practice implications for adult hemodialysis patients","volume":"29","author":"Beto","year":"2019","journal-title":"J Renal Nutr"},{"key":"2024090223531231500_hvae056-B43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"N Engl J Med"},{"key":"2024090223531231500_hvae056-B44","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1001\/jama.2020.16909","article-title":"Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH randomized clinical trial","volume":"324","author":"Bischoff-Ferrari","year":"2020","journal-title":"JAMA"},{"key":"2024090223531231500_hvae056-B45","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJMoa1900906","article-title":"Vitamin D supplementation and prevention of type 2 diabetes","volume":"381","author":"Pittas","year":"2019","journal-title":"N Engl J Med"},{"key":"2024090223531231500_hvae056-B46","doi-asserted-by":"crossref","first-page":"e075230","DOI":"10.1136\/bmj-2023-075230","article-title":"Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial","volume":"381","author":"Thompson","year":"2023","journal-title":"BMJ"},{"key":"2024090223531231500_hvae056-B47","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/jamacardio.2017.0175","article-title":"Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial","volume":"2","author":"Scragg","year":"2017","journal-title":"JAMA Cardiol"},{"key":"2024090223531231500_hvae056-B48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.numecd.2022.11.001","article-title":"Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: results from the International Polycap Study (TIPS)-3 randomized controlled trial","volume":"33","author":"Joseph","year":"2023","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2024090223531231500_hvae056-B49","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/ajcn\/nqab419","article-title":"Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish vitamin D trial: a randomized controlled trial","volume":"115","author":"Virtanen","year":"2022","journal-title":"Am J Clin Nutr"},{"key":"2024090223531231500_hvae056-B50","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s40520-022-02279-6","article-title":"Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group","volume":"34","author":"Chevalley","year":"2022","journal-title":"Aging Clin Exp Res"},{"key":"2024090223531231500_hvae056-B51","doi-asserted-by":"crossref","first-page":"e1917789","DOI":"10.1001\/jamanetworkopen.2019.17789","article-title":"Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis","volume":"2","author":"Yao","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2024090223531231500_hvae056-B52","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s00198-011-1868-7","article-title":"The 25(OH)D level needed to maintain a favorable bisphosphonate response is \u226533\u2005ng\/ml","volume":"23","author":"Carmel","year":"2012","journal-title":"Osteoporos Int"},{"key":"2024090223531231500_hvae056-B53","doi-asserted-by":"crossref","first-page":"i6583","DOI":"10.1136\/bmj.i6583","article-title":"Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data","volume":"356","author":"Martineau","year":"2017","journal-title":"BMJ"},{"key":"2024090223531231500_hvae056-B54","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S2213-8587(21)00051-6","article-title":"Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials","volume":"9","author":"Jolliffe","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2024090223531231500_hvae056-B55","doi-asserted-by":"crossref","first-page":"101923","DOI":"10.1016\/j.arr.2023.101923","article-title":"Efficacy of vitamin D3 supplementation on cancer mortality: systematic review and individual patient data meta-analysis of randomised controlled trials","volume":"87","author":"Kuznia","year":"2023","journal-title":"Ageing Res Rev"},{"key":"2024090223531231500_hvae056-B56","first-page":"CD013446","article-title":"Regimens of vitamin D supplementation for women during pregnancy","volume":"10","author":"Palacios","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"2024090223531231500_hvae056-B57","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/dc19-1708","article-title":"Effects of vitamin D supplementation on prevention of type 2 diabetes in patients with prediabetes: a systematic review and meta-analysis","volume":"43","author":"Zhang","year":"2020","journal-title":"Diabetes Care"},{"key":"2024090223531231500_hvae056-B58","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.2337\/dc20-1765","article-title":"Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study","volume":"43","author":"Dawson-Hughes","year":"2020","journal-title":"Diabetes Care"},{"key":"2024090223531231500_hvae056-B59","doi-asserted-by":"crossref","first-page":"e066452","DOI":"10.1136\/bmj-2021-066452","article-title":"Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial","volume":"376","author":"Hahn","year":"2022","journal-title":"BMJ"},{"key":"2024090223531231500_hvae056-B60","doi-asserted-by":"crossref","first-page":"e10417","DOI":"10.1002\/jbm4.10417","article-title":"Controversies in vitamin D: a statement from the third international conference","volume":"4","author":"Giustina","year":"2020","journal-title":"JBMR Plus"},{"key":"2024090223531231500_hvae056-B61","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1373\/clinchem.2015.240051","article-title":"24,25-Dihydroxyvitamin d3 and vitamin D status of community-dwelling black and white Americans","volume":"61","author":"Berg","year":"2015","journal-title":"Clin Chem"},{"key":"2024090223531231500_hvae056-B62","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1515\/cclm-2012-0522","article-title":"25-Hydroxyvitamin d testing: challenging the performance of current automated immunoassays","volume":"50","author":"Farrell","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"2024090223531231500_hvae056-B63","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/clinchem\/hvad151","article-title":"Functional assessment of vitamin D status by a novel metabolic approach: the low vitamin D profile concept","volume":"69","author":"Herrmann","year":"2023","journal-title":"Clin Chem"},{"key":"2024090223531231500_hvae056-B64","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1515\/cclm-2019-0996","article-title":"Simultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects","volume":"58","author":"Cavalier","year":"2019","journal-title":"Clin Chem Lab Med"},{"key":"2024090223531231500_hvae056-B65","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/ajcn\/84.3.602","article-title":"Optimal vitamin D status and serum parathyroid hormone concentrations in African American women","volume":"84","author":"Aloia","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"2024090223531231500_hvae056-B66","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.115.120873","article-title":"Vitamin D deficiency in Europe: pandemic?","volume":"103","author":"Cashman","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"2024090223531231500_hvae056-B67","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/nu10050533","article-title":"Vitamin D requirements for the future \u2014 lessons learned and charting a path forward","volume":"10","author":"Cashman","year":"2018","journal-title":"Nutrients"},{"key":"2024090223531231500_hvae056-B68","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00394-021-02699-6","article-title":"Individual participant data (IPD)-level meta-analysis of randomised controlled trials to estimate the vitamin D dietary requirements in dark-skinned individuals resident at high latitude","volume":"61","author":"Cashman","year":"2022","journal-title":"Eur J Nutr"},{"key":"2024090223531231500_hvae056-B69","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/jama.2020.26498","article-title":"Screening for vitamin D deficiency in adults: updated evidence report and systematic review for the US preventive services task force","volume":"325","author":"Kahwati","year":"2021","journal-title":"JAMA"},{"key":"2024090223531231500_hvae056-B70","doi-asserted-by":"crossref","first-page":"e10567","DOI":"10.1002\/jbm4.10567","article-title":"Vitamin D: bolus is bogus\u2014a narrative review","volume":"5","author":"Mazess","year":"2021","journal-title":"JBMR Plus"},{"key":"2024090223531231500_hvae056-B71","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3945\/ajcn.111.031070","article-title":"Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis","volume":"95","author":"Tripkovic","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"2024090223531231500_hvae056-B72","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cca.2015.09.021","article-title":"Serum calcitriol concentrations measured with a new direct automated assay in a large population of adult healthy subjects and in various clinical situations","volume":"451","author":"Souberbielle","year":"2015","journal-title":"Clin Chim Acta"},{"key":"2024090223531231500_hvae056-B73","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00198-018-4520-y","article-title":"Is calcifediol better than cholecalciferol for vitamin D supplementation?","volume":"29","author":"Quesada-Gomez","year":"2018","journal-title":"Osteoporos Int"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/clinchem\/article-pdf\/70\/9\/1104\/58997278\/hvae056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/clinchem\/article-pdf\/70\/9\/1104\/58997278\/hvae056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T20:41:52Z","timestamp":1725309712000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/70\/9\/1104\/7665900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":73,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5,7]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/clinchem\/hvae056","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,5,7]]}}}