{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:34:29Z","timestamp":1787787269073,"version":"build-2784847793"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100011102","name":"the 7th Framework Program RiskyCAD","doi-asserted-by":"publisher","award":["305739"],"award-info":[{"award-number":["305739"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the H2020 Program TO_AITION","award":["848146"],"award-info":[{"award-number":["848146"]}]},{"DOI":"10.13039\/100000002","name":"the U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL133399"],"award-info":[{"award-number":["R01 HL133399"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"the U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["R56 HL133399"],"award-info":[{"award-number":["R56 HL133399"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"the U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["K08 HL121801"],"award-info":[{"award-number":["K08 HL121801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Urea is elevated in chronic kidney disease (CKD) and end-stage renal disease (ESRD), and promotes the carbamylation of proteins, including human albumin, on multiple lysine side chains. Higher proportions of carbamylated albumin (C-Alb) have been associated with increased mortality risk in patients with ESRD. Whether C-Alb predicts mortality in patients with no or mild impairment of kidney function is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We measured C-Alb in 3197 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study who had been referred to coronary angiography and followed-up for 10 years. Association of baseline C-Alb with all-cause and cause-specific mortality was investigated using Cox proportional hazards regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher quartiles of C-Alb were associated with a significantly increased risk of death from any cause, with hazard ratios (HRs, 95%CI) of 1.53 (1.26\u20131.85) and 2.52 (2.11\u20133.01) in the third and fourth quartiles, respectively. After adjustment for cardiovascular (CV) risk factors, including estimate glomerular filtration rate (eGFR), the association with mortality was attenuated with a HR of 1.25 (1.02\u20131.53) for the fourth quartile as compared to the first quartile. We observed the strongest association with death due to congestive heart failure (HF) with a HR of 7.19 (4.57\u201311.3) and 3.99 (2.40\u20136.63) per 1-unit increase of log-transformed C-Alb in unadjusted and multivariate adjusted analyses, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We observed a strong association of C-Alb with CV risk in patients with no or mild CKD. This association was independent of traditional CV risk factors including eGFR and particularly strong regarding death due to congestive HF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/clinchem\/hvaf021","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T18:09:14Z","timestamp":1742407754000},"page":"587-598","source":"Crossref","is-referenced-by-count":6,"title":["Carbamylated Albumin, Heart Failure, and Mortality in Patients Undergoing Coronary Angiography"],"prefix":"10.1093","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-8958","authenticated-orcid":false,"given":"Babak","family":"Yazdani","sequence":"first","affiliation":[{"name":"Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Pneumology), University Medical Center Mannheim UMM, Faculty of Medicine of the University of Heidelberg , Mannheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela E","family":"Delgado","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Pneumology), University Medical Center Mannheim UMM, Faculty of Medicine of the University of Heidelberg , Mannheim ,","place":["Germany"]},{"name":"European Center for Angioscience, Faculty of Medicine of the University of Heidelberg , Mannheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders H","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center , Los Angeles, CA ,","place":["United 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,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Graz ,","place":["Austria"]},{"name":"Synlab Academy, Synlab Holding Deutschland GmbH , Mannheim ,","place":["Germany"]},{"name":"Medical Clinic III, Medical Faculty Heidelberg, University of Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E","family":"Kleber","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Pneumology), University Medical Center Mannheim UMM, Faculty of Medicine of the University of Heidelberg , Mannheim ,","place":["Germany"]},{"name":"SYNLAB MVZ Humangenetik Mannheim GmbH , Mannheim ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Drechsler","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Division of Nephrology, University of W\u00fcrzburg , W\u00fcrzburg ,","place":["Germany"]},{"name":"Interdisciplinary Center for Palliative Medicine, University Hospital Wuerzburg, W\u00fcrzburg, Germany ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"2025050208370584200_hvaf021-B1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"GBD Chronic Kidney Disease 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