{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:27:22Z","timestamp":1786296442241,"version":"build-2736575974"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009243","name":"DGOS","doi-asserted-by":"publisher","award":["2021\/1737"],"award-info":[{"award-number":["2021\/1737"]}],"id":[{"id":"10.13039\/501100009243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-INBS-08"],"award-info":[{"award-number":["ANR-10-INBS-08"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022395","name":"Graduate School","doi-asserted-by":"publisher","award":["ANR-17-EURE-0003"],"award-info":[{"award-number":["ANR-17-EURE-0003"]}],"id":[{"id":"10.13039\/100022395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Methylglyoxal (MGO) is a potent glycating agent that contributes to the pathogenesis of diabetes. However, MGO is unstable in plasma without demanding sample preparation at blood collection, limiting its clinical utility as a biomarker. We aimed to discover reliable MGO-glycated albumin (ALB)-derived biomarkers and to assess their association with new-onset diabetes (NOD) in people with prediabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Bottom-up mass spectrometry-based proteomics was used to discover peptide biomarkers of MGO-glycated ALB, including MGO-derived hydroimidazolone (MGH)-ALB219\u2013225, which proved to be biologically stable and reliable for large-scale analyses in human plasma. After assay validation, the IT-DIAB (Innovation Th\u00e9rapeutique DIAB\u00e8te) prospective study, conducted in 300 individuals with impaired fasting plasma glucose (FPG) levels (110 to 125\u2005mg\/dL, 6.1 to 6.9\u2005mmol\/L), was used to assess the association between plasma MGH-ALB219\u2013225 and NOD, defined as FPG \u2265126\u2005mg\/dL (7\u2005mmol\/L), using Kaplan\u2013Meier curves and Cox models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 113 participants of the IT-DIAB study developed NOD during a median follow-up of 5 years. There was a graded association between the baseline plasma MGH-ALB219\u2013225 concentration and incident NOD (log-rank P &amp;lt; 0.0001), in contrast to a lack of association for plasma MGO and total or glycated ALB (commercial kit). After adjustment for age, sex, body mass index, FPG, hemoglobin (Hb) A1c, and ALB, the plasma levels of MGH-ALB219\u2013225 were associated with NOD (hazard ratio [HR] per one SD [95% CI] = 1.50 [1.26\u20131.78]; P &amp;lt; 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MGH-ALB219\u2013225 is a novel and stable peptide biomarker of MGO-glycated ALB, whose plasma levels are positively associated with an increased risk of NOD in individuals with prediabetes, independently of traditional risk factors.<\/jats:p>\n                  <jats:p>ClinicalTrials.gov Registration Number: NCT01218061<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/clinchem\/hvaf035","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T16:24:08Z","timestamp":1744043048000},"page":"688-699","source":"Crossref","is-referenced-by-count":7,"title":["Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes"],"prefix":"10.1093","volume":"71","author":[{"given":"Ars\u00eanio","family":"Rodrigues Oliveira","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax , Nantes ,","place":["France"]},{"name":"New Biomarkers Department, Sebia , Evry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-9486","authenticated-orcid":false,"given":"Matthieu","family":"Wargny","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax , Nantes ,","place":["France"]},{"name":"CHU de Nantes, INSERM CIC 1413, P\u00f4le Hospitalo-Universitaire 11: Sant\u00e9 Publique, Clinique des donn\u00e9es , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Pakulska","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, CEA, INSERM, UA13 BGE, CNRS, CEA, FR2048 , Grenoble ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Caradeuc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , Paris ,","place":["France"]},{"name":"MetaboParis-Sant\u00e9, BioMedTech Facilities\u2014Inserm US36, CNRS UAR2009, Universit\u00e9 Paris Cit\u00e9 , Paris 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CHU Nantes, G et R La\u00ebnnec Hospital, Bd Jacques Monod , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Nouadje","sequence":"additional","affiliation":[{"name":"New Biomarkers Department, Sebia , Evry ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-6196","authenticated-orcid":false,"given":"Yohann","family":"Cout\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, CEA, INSERM, UA13 BGE, CNRS, CEA, FR2048 , Grenoble ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Le May","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax , Nantes 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