{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:59:41Z","timestamp":1787655581551,"version":"build-2736575974"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital heart defects (CHDs) are the most prevalent birth defects, contributing significantly to infant morbidity and mortality. While genetic factors account for a subset of CHDs, environmental exposures during critical periods of cardiac development are increasingly recognized as potential contributors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>This review synthesizes current evidence linking per- and polyfluoroalkyl substances, polycyclic aromatic hydrocarbons, and other environmental contaminants to CHDs. We discuss epidemiological findings, biological mechanisms, exposure assessment methodologies, and future research directions, emphasizing the need for integrated approaches in understanding and mitigating environmental risks to fetal cardiac development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>This review emphasizes the need for integrated approaches in understanding and mitigating environmental risks to fetal cardiac development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/clinchem\/hvaf158","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:01:54Z","timestamp":1761742914000},"page":"133-139","source":"Crossref","is-referenced-by-count":3,"title":["Environmental Contaminants and Congenital Heart Defects: Focus on PFAS, PAHs, and Other Emerging Exposures"],"prefix":"10.1093","volume":"72","author":[{"given":"Jenil","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Epidemiology, UTHealth Houston School of Public Health , Dallas, TX ,","place":["United States"]},{"name":"Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health , Little Rock, AR ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Weber","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health , Little Rock, AR ,","place":["United States"]},{"name":"Department of Epidemiology, Fay W. Boozman College of Public Health , Little Rock, AR ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health , Little Rock, AR ,","place":["United States"]},{"name":"Department of Epidemiology, Fay W. Boozman College of Public Health , Little Rock, AR ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-4049","authenticated-orcid":false,"given":"Wendy N","family":"Nembhard","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention, Fay W. Boozman College of Public Health , Little Rock, AR ,","place":["United States"]},{"name":"Department of Epidemiology, Fay W. 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