{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:05:59Z","timestamp":1783681559343,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation-Flanders","doi-asserted-by":"publisher","award":["1S74420N"],"award-info":[{"award-number":["1S74420N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation-Flanders","doi-asserted-by":"publisher","award":["1S93025N"],"award-info":[{"award-number":["1S93025N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FWO-SBO","award":["S003422N"],"award-info":[{"award-number":["S003422N"]}]},{"DOI":"10.13039\/501100013845","name":"Stichting tegen Kanker","doi-asserted-by":"publisher","award":["2018-134"],"award-info":[{"award-number":["2018-134"]}],"id":[{"id":"10.13039\/501100013845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013845","name":"Stichting tegen Kanker","doi-asserted-by":"publisher","award":["C\/2024\/2808"],"award-info":[{"award-number":["C\/2024\/2808"]}],"id":[{"id":"10.13039\/501100013845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011851","name":"Kom op tegen Kanker","doi-asserted-by":"publisher","award":["2018\/11468"],"award-info":[{"award-number":["2018\/11468"]}],"id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020","award":["824110"],"award-info":[{"award-number":["824110"]}]},{"name":"EASI-Genomics"},{"name":"European Commission EU4Health CAN.HEAL","award":["101080009"],"award-info":[{"award-number":["101080009"]}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C1-C14\/18\/092"],"award-info":[{"award-number":["C1-C14\/18\/092"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/22\/125"],"award-info":[{"award-number":["C14\/22\/125"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C3\/20\/100"],"award-info":[{"award-number":["C3\/20\/100"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prenatal cell-free DNA (cfDNA) screening is primarily designed to detect fetal chromosomal abnormalities, but can also identify aneuploidies derived from other tissues, including cancer. The identification of aneuploidies of unknown origin during prenatal cfDNA screening can lead to time-consuming multistage investigations and anxiety for the expecting mother.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To expedite the identification of the origin of copy-number aberrations and guide clinical management of such profiles suggestive of maternal malignancy, we developed a methylation and aneuploidy-aware prenatal screening pipeline. Plasma cfDNA is enzymatically converted to identify the methylated cytosines during sequencing. The tissue of origin is predicted by leveraging a cell-type-specific methylome atlas into our methylation-based deconvolution algorithm, MetDecode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrate that aneuploidy profiling on enzymatically converted cfDNA enables the identification of placental and cancer-derived aneuploidies with similar accuracy compared with conventional prenatal cfDNA screening. The methylation-based deconvolution pinpointed the tumor origin correctly in 91.67% of the pregnant women with a tumor fraction &amp;gt;3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Methylome and aneuploidy-aware cfDNA screening could substantially improve the diagnostic processes, pinpoint the origins of aneuploidy and improve cancer management during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/clinchem\/hvaf167","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:38:13Z","timestamp":1763645893000},"page":"367-380","source":"Crossref","is-referenced-by-count":1,"title":["Copy-Number Profiling and Methylation-Based Tumor Typing during Prenatal Cell-Free DNA Screening"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-4295","authenticated-orcid":false,"given":"Stefania","family":"Tuveri","sequence":"first","affiliation":[{"name":"Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Jatsenko","sequence":"additional","affiliation":[{"name":"Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanya","family":"Sudhakaran","sequence":"additional","affiliation":[{"name":"Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-7311","authenticated-orcid":false,"given":"Antoine","family":"Passemiers","sequence":"additional","affiliation":[{"name":"Dynamical Systems, Signal Processing and Data Analytics (STADIUS), KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Pagliazzi","sequence":"additional","affiliation":[{"name":"Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Van Den Bogaert","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Vancoillie","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Parijs","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Brison","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Van Calsteren","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, University Hospitals KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, University Hospitals KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Naesens","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Laboratory for Malignant Disorders, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-4905","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Amant","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics, University Hospitals KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Gynaecological Oncology, Department of Oncology, KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Gynaecologic Oncology, Netherlands Cancer Institute , Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology, Department of Oncology, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-1191","authenticated-orcid":false,"given":"Joris R","family":"Vermeesch","sequence":"additional","affiliation":[{"name":"Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven , Leuven ,","place":["Belgium"]},{"name":"Center for Human Genetics, University Hospitals Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"2026030508531585400_hvaf167-B1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/ejhg.2014.282","article-title":"Noninvasive prenatal testing using a novel analysis pipeline to screen for all autosomal fetal aneuploidies improves pregnancy management","volume":"23","author":"Bayindir","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"2026030508531585400_hvaf167-B2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/302205","article-title":"Rapid clearance of fetal DNA from maternal plasma","volume":"64","author":"Lo","year":"1999","journal-title":"Am J Hum Genet"},{"key":"2026030508531585400_hvaf167-B3","doi-asserted-by":"crossref","first-page":"E5503","DOI":"10.1073\/pnas.1508736112","article-title":"Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments","volume":"112","author":"Sun","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026030508531585400_hvaf167-B4","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1038\/s41467-021-22901-x","article-title":"Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE","volume":"12","author":"Caggiano","year":"2021","journal-title":"Nat Commun"},{"key":"2026030508531585400_hvaf167-B5","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/pd.5544","article-title":"Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing","volume":"39","author":"Lenaerts","year":"2019","journal-title":"Prenat Diagn"},{"key":"2026030508531585400_hvaf167-B6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1001\/jama.2015.7120","article-title":"Noninvasive prenatal testing and incidental detection of occult maternal malignancies","volume":"314","author":"Bianchi","year":"2015","journal-title":"JAMA"},{"key":"2026030508531585400_hvaf167-B7","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1002\/ccr3.3027","article-title":"Noninvasive prenatal testing detected acute myeloid leukemia in paucisymptomatic pregnant patient","volume":"8","author":"Rengifo","year":"2020","journal-title":"Clin Case Rep"},{"key":"2026030508531585400_hvaf167-B8","doi-asserted-by":"crossref","first-page":"100856","DOI":"10.1016\/j.eclinm.2021.100856","article-title":"Comprehensive genome-wide analysis of routine non-invasive test data allows cancer prediction: a single-center retrospective analysis of over 85,000 pregnancies","volume":"35","author":"Lenaerts","year":"2021","journal-title":"EClinicalMedicine"},{"key":"2026030508531585400_hvaf167-B9","first-page":"285","article-title":"Non-invasive prenatal testing: when results suggests maternal cancer","volume":"35","author":"Lenaerts","year":"2023","journal-title":"Med Genet"},{"key":"2026030508531585400_hvaf167-B10","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1200\/JCO.21.02260","article-title":"Noninvasive prenatal test results indicative of maternal malignancies: a nationwide genetic and clinical follow-up study","volume":"40","author":"Heesterbeek","year":"2022","journal-title":"J Clin Oncol"},{"key":"2026030508531585400_hvaf167-B11","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/1471-0528.17074","article-title":"Cancer in pregnancy and the risk of adverse pregnancy and neonatal outcomes: a nationwide cohort study","volume":"129","author":"Greiber","year":"2022","journal-title":"BJOG"},{"key":"2026030508531585400_hvaf167-B12","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3390\/cancers12061356","article-title":"Frequency of pregnancy-associated cancer: a systematic review of population-based studies","volume":"12","author":"Dalmartello","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2026030508531585400_hvaf167-B13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11912-020-0862-7","article-title":"Pregnancy and cancer: the INCIP project","volume":"22","author":"Maggen","year":"2020","journal-title":"Curr Oncol Rep"},{"key":"2026030508531585400_hvaf167-B14","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2214\/AJR.06.1616","article-title":"ACR guidance document for safe MR practices: 2007","volume":"188","author":"Kanal","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"2026030508531585400_hvaf167-B15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejca.2005.10.014","article-title":"Cancer and pregnancy: poena magna, not anymore","volume":"42","author":"Pentheroudakis","year":"2006","journal-title":"Eur J Cancer"},{"key":"2026030508531585400_hvaf167-B16","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1200\/OP.23.00594","article-title":"Comprehensive recommendations for the clinical management of pregnant women with noninvasive prenatal test results suspicious of a maternal malignancy","volume":"20","author":"Heesterbeek","year":"2024","journal-title":"JCO Oncol Pract"},{"key":"2026030508531585400_hvaf167-B17","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1038\/s41467-018-07466-6","article-title":"Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease","volume":"9","author":"Moss","year":"2018","journal-title":"Nat Commun"},{"key":"2026030508531585400_hvaf167-B18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-022-05580-6","article-title":"A DNA methylation atlas of normal human cell types","volume":"613","author":"Loyfer","year":"2023","journal-title":"Nature"},{"key":"2026030508531585400_hvaf167-B19","doi-asserted-by":"crossref","first-page":"btae522","DOI":"10.1093\/bioinformatics\/btae522","article-title":"MetDecode: methylation-based deconvolution of cell-free DNA for noninvasive multi-cancer typing","volume":"40","author":"Passemiers","year":"2024","journal-title":"Bioinformatics"},{"key":"2026030508531585400_hvaf167-B20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41467-017-00965-y","article-title":"Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors","volume":"8","author":"Adalsteinsson","year":"2017","journal-title":"Nat Commun"},{"key":"2026030508531585400_hvaf167-B21","doi-asserted-by":"publisher","author":"Loyfer","DOI":"10.1101\/2024.05.08.593132"},{"key":"2026030508531585400_hvaf167-B22","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/pd.4615","article-title":"Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts","volume":"35","author":"Kim","year":"2015","journal-title":"Prenat Diagn"},{"key":"2026030508531585400_hvaf167-B23","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/bioinformatics\/btw325","article-title":"GenVisR: genomic visualizations in R","volume":"32","author":"Skidmore","year":"2016","journal-title":"Bioinformatics"},{"key":"2026030508531585400_hvaf167-B24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.23736\/S2724-606X.24.05483-6","article-title":"Dysgerminoma of the ovary","volume":"77","author":"Friedrich","year":"2025","journal-title":"Minerva Obstet Gynecol"},{"key":"2026030508531585400_hvaf167-B25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/gcc.20833","article-title":"Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors","volume":"50","author":"Joosse","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"2026030508531585400_hvaf167-B26","doi-asserted-by":"crossref","first-page":"E1826","DOI":"10.1073\/pnas.1519286113","article-title":"Identification of tissue-specific cell death using methylation patterns of circulating DNA","volume":"113","author":"Lehmann-Werman","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026030508531585400_hvaf167-B27","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1373\/clinchem.2013.212274","article-title":"Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA","volume":"59","author":"Lun","year":"2013","journal-title":"Clin Chem"},{"key":"2026030508531585400_hvaf167-B28","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.1215145110","article-title":"The human placenta methylome","volume":"110","author":"Schroeder","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026030508531585400_hvaf167-B29","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1080\/15592294.2017.1342912","article-title":"The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors","volume":"12","author":"Nordor","year":"2017","journal-title":"Epigenetics"},{"key":"2026030508531585400_hvaf167-B30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2009.00716.x","article-title":"Epigenetics in the placenta","volume":"62","author":"Maccani","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"2026030508531585400_hvaf167-B31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"2026030508531585400_hvaf167-B32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/301089a0","article-title":"Hypomethylation distinguishes genes of some human cancers from their normal counterparts","volume":"301","author":"Feinberg","year":"1983","journal-title":"Nature"},{"key":"2026030508531585400_hvaf167-B33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4419-9967-2_2","article-title":"DNA hypomethylation and hemimethylation in cancer","volume":"754","author":"Ehrlich","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"2026030508531585400_hvaf167-B34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41551-021-00837-3","article-title":"Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics","volume":"6","author":"Song","year":"2022","journal-title":"Nat Biomed Eng"},{"key":"2026030508531585400_hvaf167-B35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1136\/ijgc-2023-004609","article-title":"Staging by imaging in gynecologic cancer and the role of ultrasound: an update of European joint consensus statements","volume":"34","author":"Fischerova","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"2026030508531585400_hvaf167-B36","first-page":"22","article-title":"The limitations of multiparametric magnetic resonance imaging also must be borne in mind","volume":"69","author":"Sosnowski","year":"2016","journal-title":"Cent European J Urol"},{"key":"2026030508531585400_hvaf167-B37","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3390\/diagnostics13071276","article-title":"Imaging in gastric cancer: current practice and future perspectives","volume":"13","author":"Giandola","year":"2023","journal-title":"Diagnostics"},{"key":"2026030508531585400_hvaf167-B38","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/jmri.26848","article-title":"MRI and PET\/MRI in hematologic malignancies","volume":"51","author":"Mayerhoefer","year":"2019","journal-title":"J Magn Reson Imaging"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/clinchem\/article-pdf\/72\/3\/367\/66294206\/hvaf167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/clinchem\/article-pdf\/72\/3\/367\/66294206\/hvaf167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:53:26Z","timestamp":1772718806000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/72\/3\/367\/8416537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,1,7]]},"published-print":{"date-parts":[[2026,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/clinchem\/hvaf167","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,1,7]]}}}